MIC10_CAEEL
ID MIC10_CAEEL Reviewed; 105 AA.
AC Q9N4K0;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=MICOS complex subunit Mic10;
GN ORFNames=F54A3.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}. Note=The C-terminus is
CC located in the intermembrane space, while the location of the N-
CC terminus has not been determined yet. As some programs predict the
CC presence of 2 closely apposed membrane domains, it has been proposed
CC that the protein may cross the membrane twice and that both termini may
CC face the intermembrane space (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic10 family.
CC {ECO:0000305}.
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DR EMBL; FO081460; CCD71743.1; -; Genomic_DNA.
DR RefSeq; NP_494216.1; NM_061815.3.
DR AlphaFoldDB; Q9N4K0; -.
DR BioGRID; 38947; 8.
DR IntAct; Q9N4K0; 1.
DR STRING; 6239.F54A3.5; -.
DR EPD; Q9N4K0; -.
DR PaxDb; Q9N4K0; -.
DR PeptideAtlas; Q9N4K0; -.
DR EnsemblMetazoa; F54A3.5.1; F54A3.5.1; WBGene00018784.
DR GeneID; 173579; -.
DR KEGG; cel:CELE_F54A3.5; -.
DR UCSC; F54A3.5.1; c. elegans.
DR CTD; 173579; -.
DR WormBase; F54A3.5; CE25901; WBGene00018784; -.
DR eggNOG; KOG4604; Eukaryota.
DR GeneTree; ENSGT00940000168269; -.
DR HOGENOM; CLU_068905_2_0_1; -.
DR InParanoid; Q9N4K0; -.
DR OMA; NCRHDFA; -.
DR OrthoDB; 1625075at2759; -.
DR PhylomeDB; Q9N4K0; -.
DR PRO; PR:Q9N4K0; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00018784; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR InterPro; IPR007512; Mic10.
DR PANTHER; PTHR21304; PTHR21304; 1.
DR Pfam; PF04418; DUF543; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..105
FT /note="MICOS complex subunit Mic10"
FT /id="PRO_0000221636"
FT TRANSMEM 29..46
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..105
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 85..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 105 AA; 11133 MW; F3537B62F187072D CRC64;
MAPGASAPAA SRSEDEVGQK IDRCFADSLL KVTGGVAIGI VASVAFFKSR SWPIWFGSGV
GLGTGWSNCR HDFASPYVLH GKRVPAGQDS QGKPAYNIIT EQHKQ
