ID   MIC10_NEUCR             Reviewed;          93 AA.
AC   Q7RYI0;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=MICOS complex subunit mic10;
DE   AltName: Full=Mitochondrial inner membrane organizing system protein 1;
GN   Name=mic10; ORFNames=NCU06495;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Note=The C-terminus is
CC       located in the intermembrane space, while the location of the N-
CC       terminus has not been determined yet. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic10 family.
CC       {ECO:0000305}.
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DR   EMBL; CM002238; EAA27899.1; -; Genomic_DNA.
DR   RefSeq; XP_957135.1; XM_952042.3.
DR   AlphaFoldDB; Q7RYI0; -.
DR   STRING; 5141.EFNCRP00000006220; -.
DR   EnsemblFungi; EAA27899; EAA27899; NCU06495.
DR   GeneID; 3873273; -.
DR   KEGG; ncr:NCU06495; -.
DR   VEuPathDB; FungiDB:NCU06495; -.
DR   HOGENOM; CLU_068905_1_0_1; -.
DR   InParanoid; Q7RYI0; -.
DR   OMA; SNCRHDL; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0061617; C:MICOS complex; IEA:EnsemblFungi.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:EnsemblFungi.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; IEA:EnsemblFungi.
DR   InterPro; IPR007512; Mic10.
DR   PANTHER; PTHR21304; PTHR21304; 1.
DR   Pfam; PF04418; DUF543; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..93
FT                   /note="MICOS complex subunit mic10"
FT                   /id="PRO_0000221638"
FT   TRANSMEM        34..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        57..93
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   93 AA;  9979 MW;  C6F9E9584C756D10 CRC64;
     MSDSTSSPVA AAPSTAMTRP VSEALLNEKW DRCLSNLLIK STLGLGFGVV FSVLIFKRRA
     WPAFVGVGFG AGRAYEECNT SLKQAAREIR AQA