ID   MIC10_SCHPO             Reviewed;          86 AA.
AC   Q9HFF0;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=MICOS complex subunit mic10;
DE   AltName: Full=Mitochondrial inner membrane organizing system protein PJ691.03;
GN   Name=mic10; ORFNames=SPAPJ691.03;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}. Note=The C-terminus is
CC       located in the intermembrane space, while the location of the N-
CC       terminus is has not been determined yet. As some programs predict the
CC       presence of 2 closely apposed membrane domains, it has been proposed
CC       that the protein may cross the membrane twice and that both termini may
CC       face the intermembrane space (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic10 family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAC14019.1; -; Genomic_DNA.
DR   RefSeq; NP_594896.1; NM_001020325.2.
DR   AlphaFoldDB; Q9HFF0; -.
DR   BioGRID; 279737; 16.
DR   STRING; 4896.SPAPJ691.03.1; -.
DR   PaxDb; Q9HFF0; -.
DR   EnsemblFungi; SPAPJ691.03.1; SPAPJ691.03.1:pep; SPAPJ691.03.
DR   GeneID; 2543313; -.
DR   KEGG; spo:SPAPJ691.03; -.
DR   PomBase; SPAPJ691.03; mic10.
DR   VEuPathDB; FungiDB:SPAPJ691.03; -.
DR   eggNOG; KOG4604; Eukaryota.
DR   HOGENOM; CLU_068905_2_0_1; -.
DR   InParanoid; Q9HFF0; -.
DR   OMA; SNCRHDL; -.
DR   PhylomeDB; Q9HFF0; -.
DR   PRO; PR:Q9HFF0; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0061617; C:MICOS complex; ISO:PomBase.
DR   GO; GO:0044284; C:mitochondrial crista junction; ISO:PomBase.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; ISO:PomBase.
DR   InterPro; IPR007512; Mic10.
DR   PANTHER; PTHR21304; PTHR21304; 1.
DR   Pfam; PF04418; DUF543; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..86
FT                   /note="MICOS complex subunit mic10"
FT                   /id="PRO_0000221639"
FT   TRANSMEM        22..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        42..86
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   86 AA;  9309 MW;  7131F37D173A801A CRC64;
     MSTSQSSEQT LNYQWDVCLS NMVVQSGIGL GAGIVSSVLF FRRAAWPVWG GLGFGLGKSY
     ADSNARLRTF HAIPKQLPAS STQKKD