ID   MIC12_ASHGO             Reviewed;          94 AA.
AC   Q752G2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=MICOS complex subunit MIC12;
DE   AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 51;
GN   Name=AIM5; Synonyms=FMP51; OrderedLocusNames=AFR614W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS53985.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE016819; AAS53985.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_986161.1; NM_212297.1.
DR   AlphaFoldDB; Q752G2; -.
DR   GeneID; 4622446; -.
DR   KEGG; ago:AGOS_AFR614W; -.
DR   eggNOG; ENOG502S8MU; Eukaryota.
DR   InParanoid; Q752G2; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:InterPro.
DR   GO; GO:0042407; P:cristae formation; IEA:InterPro.
DR   InterPro; IPR031463; Mic12.
DR   Pfam; PF17050; AIM5; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..94
FT                   /note="MICOS complex subunit MIC12"
FT                   /id="PRO_0000399888"
FT   TRANSMEM        7..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   94 AA;  11106 MW;  CADB712B2EBFFCB7 CRC64;
     MPRLLRYGSF SVVASVLGAS YYYYAVASPL YTEAEWHRVS QRTAALIDRR IDIPVPESTT
     ERREYVVRSS KETMKDIWNE QIRSIVDWIY SWSH