ID   MIC12_KLULA             Reviewed;          94 AA.
AC   Q6CLL5;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=MICOS complex subunit MIC12;
DE   AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 51;
GN   Name=AIM5; Synonyms=FMP51; OrderedLocusNames=KLLA0F02079g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382126; CAG97881.1; -; Genomic_DNA.
DR   RefSeq; XP_455174.1; XM_455174.1.
DR   AlphaFoldDB; Q6CLL5; -.
DR   STRING; 284590.Q6CLL5; -.
DR   EnsemblFungi; CAG97881; CAG97881; KLLA0_F02079g.
DR   GeneID; 2894826; -.
DR   KEGG; kla:KLLA0_F02079g; -.
DR   eggNOG; ENOG502S8MU; Eukaryota.
DR   HOGENOM; CLU_164154_0_0_1; -.
DR   InParanoid; Q6CLL5; -.
DR   OMA; MKDIWNE; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:InterPro.
DR   GO; GO:0042407; P:cristae formation; IEA:InterPro.
DR   InterPro; IPR031463; Mic12.
DR   Pfam; PF17050; AIM5; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..94
FT                   /note="MICOS complex subunit MIC12"
FT                   /id="PRO_0000399890"
FT   TRANSMEM        4..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   94 AA;  11095 MW;  DDF6D151E4237B35 CRC64;
     MSKLLKLTGF TTLSTLLGVS YYYYVIDRPL YQQTALHKTN VQVENIIDNK AQFQYEHMSR
     DSQAVVQRPF AETVKDIWNK EVRNTADWLY SWGK