ID   MIC12_VANPO             Reviewed;         100 AA.
AC   A7TMN2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=MICOS complex subunit MIC12;
DE   AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 51;
GN   Name=AIM5; Synonyms=FMP51; ORFNames=Kpol_1066p10;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC       {ECO:0000305}.
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DR   EMBL; DS480424; EDO16446.1; -; Genomic_DNA.
DR   RefSeq; XP_001644304.1; XM_001644254.1.
DR   AlphaFoldDB; A7TMN2; -.
DR   EnsemblFungi; EDO16446; EDO16446; Kpol_1066p10.
DR   GeneID; 5544603; -.
DR   KEGG; vpo:Kpol_1066p10; -.
DR   HOGENOM; CLU_164154_0_0_1; -.
DR   InParanoid; A7TMN2; -.
DR   OrthoDB; 1600315at2759; -.
DR   PhylomeDB; A7TMN2; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..100
FT                   /note="MICOS complex subunit MIC12"
FT                   /id="PRO_0000399892"
FT   TRANSMEM        10..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   100 AA;  11626 MW;  27BBC5208F6C770A CRC64;
     MSKIWKFTSF ATISSVAAAS LYLYAIDKNG YYYEKSKFKQ VTDRVRKLID GDETFKYVTI
     DDFVSGPTQI QTRSRGETFK DLWNAEVRRT AQWIYSLGGR