ID   MIC12_YEAS7             Reviewed;         106 AA.
AC   A6ZLK2;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-SEP-2007, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=MICOS complex subunit MIC12;
DE   AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 51;
GN   Name=AIM5; Synonyms=FMP51; ORFNames=SCY_0472;
OS   Saccharomyces cerevisiae (strain YJM789) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=307796;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJM789;
RX   PubMed=17652520; DOI=10.1073/pnas.0701291104;
RA   Wei W., McCusker J.H., Hyman R.W., Jones T., Ning Y., Cao Z., Gu Z.,
RA   Bruno D., Miranda M., Nguyen M., Wilhelmy J., Komp C., Tamse R., Wang X.,
RA   Jia P., Luedi P., Oefner P.J., David L., Dietrich F.S., Li Y., Davis R.W.,
RA   Steinmetz L.M.;
RT   "Genome sequencing and comparative analysis of Saccharomyces cerevisiae
RT   strain YJM789.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:12825-12830(2007).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC       {ECO:0000305}.
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DR   EMBL; AAFW02000011; EDN64871.1; -; Genomic_DNA.
DR   AlphaFoldDB; A6ZLK2; -.
DR   SMR; A6ZLK2; -.
DR   EnsemblFungi; EDN64871; EDN64871; SCY_0472.
DR   HOGENOM; CLU_164154_0_0_1; -.
DR   Proteomes; UP000007060; Unassembled WGS sequence.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:InterPro.
DR   GO; GO:0042407; P:cristae formation; IEA:InterPro.
DR   InterPro; IPR031463; Mic12.
DR   Pfam; PF17050; AIM5; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..106
FT                   /note="MICOS complex subunit MIC12"
FT                   /id="PRO_0000399895"
FT   TRANSMEM        11..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   106 AA;  12388 MW;  357863592C1E92CF CRC64;
     MSKLGPLARS VKWTLSVGVI GSVFYLYRYS NNGYFYDHDA TWLKQDHQVQ DLVDRKEVVP
     GETRNRKLVV TDDGTAWSRT MGESIKDIWN EQIRNSVDWI YSWGKN