ID   MIC12_YEAS8             Reviewed;         106 AA.
AC   D3UF10;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=MICOS complex subunit MIC12;
DE   AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE   AltName: Full=Found in mitochondrial proteome protein 51;
GN   Name=AIM5; Synonyms=FMP51; ORFNames=EC1118_1B15_4445g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC       {ECO:0000305}.
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DR   EMBL; FN393060; CBK39340.1; -; Genomic_DNA.
DR   AlphaFoldDB; D3UF10; -.
DR   SMR; D3UF10; -.
DR   EnsemblFungi; CBK39340; CBK39340; EC1118_1B15_4445g.
DR   HOGENOM; CLU_164154_0_0_1; -.
DR   Proteomes; UP000000286; Chromosome II, Scaffold EC1118_1B15.
DR   GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:InterPro.
DR   GO; GO:0042407; P:cristae formation; IEA:InterPro.
DR   InterPro; IPR031463; Mic12.
DR   Pfam; PF17050; AIM5; 1.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..106
FT                   /note="MICOS complex subunit MIC12"
FT                   /id="PRO_0000399896"
FT   TRANSMEM        11..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   106 AA;  12388 MW;  357863592C1E92CF CRC64;
     MSKLGPLARS VKWTLSVGVI GSVFYLYRYS NNGYFYDHDA TWLKQDHQVQ DLVDRKEVVP
     GETRNRKLVV TDDGTAWSRT MGESIKDIWN EQIRNSVDWI YSWGKN