MIC12_ZYGRC
ID MIC12_ZYGRC Reviewed; 97 AA.
AC C5DRK2; Q9UVE5;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=MICOS complex subunit MIC12;
DE AltName: Full=Altered inheritance of mitochondria protein 5, mitochondrial;
DE AltName: Full=Found in mitochondrial proteome protein 51;
GN Name=AIM5; Synonyms=FMP51; OrderedLocusNames=ZYRO0B09108g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10806420;
RX DOI=10.1002/(sici)1097-0061(200005)16:7<581::aid-yea545>3.0.co;2-4;
RA Sychrova H., Braun V., Souciet J.-L.;
RT "Sequence and organization analyses of a Zygosaccharomyces rouxii DNA
RT fragment containing the HIS3 gene.";
RL Yeast 16:581-587(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic12 family.
CC {ECO:0000305}.
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DR EMBL; Y18560; CAB62287.1; -; Genomic_DNA.
DR EMBL; CU928174; CAR26413.1; -; Genomic_DNA.
DR RefSeq; XP_002495346.1; XM_002495301.1.
DR AlphaFoldDB; C5DRK2; -.
DR STRING; 559307.C5DRK2; -.
DR EnsemblFungi; CAR26413; CAR26413; ZYRO0B09108g.
DR GeneID; 8202498; -.
DR KEGG; zro:ZYRO0B09108g; -.
DR HOGENOM; CLU_164154_0_0_1; -.
DR InParanoid; C5DRK2; -.
DR Proteomes; UP000008536; Chromosome B.
DR GO; GO:0061617; C:MICOS complex; IEA:InterPro.
DR GO; GO:0044284; C:mitochondrial crista junction; IEA:InterPro.
DR GO; GO:0042407; P:cristae formation; IEA:InterPro.
DR InterPro; IPR031463; Mic12.
DR Pfam; PF17050; AIM5; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..97
FT /note="MICOS complex subunit MIC12"
FT /id="PRO_0000399897"
FT TRANSMEM 7..24
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 97 AA; 11188 MW; 8810CD8329D3A834 CRC64;
MSKLIKLTSI TAVSSTLAAS YYFYFVDRDG FHYQNSQWKK IGDKVQGIID GSENINPSTP
SNSNQVIVVK RPMTETMKDL WNEQIRNTAN WFYSWGK
