MIC13_DANRE
ID MIC13_DANRE Reviewed; 111 AA.
AC Q1LUK1; Q1LUK0;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=MICOS complex subunit MIC13 {ECO:0000250|UniProtKB:Q5XKP0};
GN Name=micos13 {ECO:0000250|UniProtKB:Q5XKP0}; Synonyms=mic13, qil1;
GN ORFNames=si:dkey-78l4.14;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Constituent of mature
CC MICOS complex, it is required for the formation of cristae junction
CC (CJ) and maintenance of cristae morphology. Required for the
CC incorporation of MIC10 into the MICOS complex.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5XKP0}; Single-pass membrane protein
CC {ECO:0000255}. Note=Enriched at crista junctions.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAK11205.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX936298; CAK11204.1; -; Genomic_DNA.
DR EMBL; BX936298; CAK11205.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC133965; AAI33966.1; -; mRNA.
DR RefSeq; NP_001038338.1; NM_001044873.1.
DR AlphaFoldDB; Q1LUK1; -.
DR STRING; 7955.ENSDARP00000096258; -.
DR PaxDb; Q1LUK1; -.
DR Ensembl; ENSDART00000105485; ENSDARP00000096258; ENSDARG00000071378.
DR GeneID; 558738; -.
DR KEGG; dre:558738; -.
DR CTD; 125988; -.
DR ZFIN; ZDB-GENE-050309-178; micos13.
DR eggNOG; ENOG502S4BC; Eukaryota.
DR GeneTree; ENSGT00390000002629; -.
DR HOGENOM; CLU_152642_0_1_1; -.
DR InParanoid; Q1LUK1; -.
DR OMA; GIIKVMS; -.
DR OrthoDB; 1599526at2759; -.
DR PhylomeDB; Q1LUK1; -.
DR TreeFam; TF343386; -.
DR PRO; PR:Q1LUK1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000071378; Expressed in heart and 20 other tissues.
DR ExpressionAtlas; Q1LUK1; baseline.
DR GO; GO:0061617; C:MICOS complex; ISS:UniProtKB.
DR GO; GO:0044284; C:mitochondrial crista junction; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR InterPro; IPR026769; Mic13.
DR PANTHER; PTHR31816; PTHR31816; 1.
DR Pfam; PF15884; QIL1; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..111
FT /note="MICOS complex subunit MIC13"
FT /id="PRO_0000360980"
FT TRANSMEM 8..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 63
FT /note="L -> V (in Ref. 1; CAK11205)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 111 AA; 11753 MW; 7E03C4138649545F CRC64;
MAAKIFPVVK FATKVTIAGG ALYVAYDSGL LGGSNEGSVA LARAKSAIPP AVDEWMKYFG
FELPATPKIE FSPLDAWNSG VQKSIHALSV APSTVGDYTK QGLQYVKDLS K
