MIC13_DROME
ID MIC13_DROME Reviewed; 122 AA.
AC Q9VVH3;
DT 22-JUL-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=MICOS complex subunit MIC13 homolog QIL1 {ECO:0000305};
GN Name=QIL1 {ECO:0000312|FlyBase:FBgn0036726};
GN ORFNames=CG7603 {ECO:0000312|FlyBase:FBgn0036726};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP FUNCTION.
RX PubMed=25997101; DOI=10.7554/elife.06265;
RA Guarani V., McNeill E.M., Paulo J.A., Huttlin E.L., Froehlich F.,
RA Gygi S.P., Van Vactor D., Harper J.W.;
RT "QIL1 is a novel mitochondrial protein required for MICOS complex stability
RT and cristae morphology.";
RL Elife 4:0-0(2015).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000269|PubMed:25997101}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5XKP0}; Single-pass membrane protein
CC {ECO:0000255}. Note=Enriched at crista junctions.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014296; AAF49338.1; -; Genomic_DNA.
DR EMBL; AY071567; AAL49189.1; -; mRNA.
DR RefSeq; NP_648983.1; NM_140726.3.
DR AlphaFoldDB; Q9VVH3; -.
DR IntAct; Q9VVH3; 1.
DR STRING; 7227.FBpp0074982; -.
DR PaxDb; Q9VVH3; -.
DR PRIDE; Q9VVH3; -.
DR DNASU; 39948; -.
DR EnsemblMetazoa; FBtr0075220; FBpp0074982; FBgn0036726.
DR GeneID; 39948; -.
DR KEGG; dme:Dmel_CG7603; -.
DR UCSC; CG7603-RA; d. melanogaster.
DR CTD; 39948; -.
DR FlyBase; FBgn0036726; QIL1.
DR VEuPathDB; VectorBase:FBgn0036726; -.
DR eggNOG; ENOG502S7FS; Eukaryota.
DR HOGENOM; CLU_137714_1_0_1; -.
DR InParanoid; Q9VVH3; -.
DR OMA; KNTFRFI; -.
DR OrthoDB; 1599526at2759; -.
DR PhylomeDB; Q9VVH3; -.
DR BioGRID-ORCS; 39948; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 39948; -.
DR PRO; PR:Q9VVH3; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0036726; Expressed in adult hindgut (Drosophila) and 26 other tissues.
DR ExpressionAtlas; Q9VVH3; baseline and differential.
DR Genevisible; Q9VVH3; DM.
DR GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR GO; GO:0044284; C:mitochondrial crista junction; IBA:GO_Central.
DR GO; GO:0042407; P:cristae formation; IMP:UniProtKB.
DR GO; GO:1903850; P:regulation of cristae formation; IMP:FlyBase.
DR InterPro; IPR026769; Mic13.
DR PANTHER; PTHR31816; PTHR31816; 1.
DR Pfam; PF15884; QIL1; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..122
FT /note="MICOS complex subunit MIC13 homolog QIL1"
FT /id="PRO_0000433598"
FT TRANSMEM 9..25
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 122 AA; 13750 MW; FB3697B2AB43FE60 CRC64;
MVLGFLVRGG LVAATVYYTQ KVGIWGDSDQ TDKLYNDIKS ELRPHVQKLE KQLPFEVPQL
PKTGEMRFLA KHYYNEGVKN TFRFIHMLPC YAGRGLKKVK DTFQDFAQSP AIAGGAESSP
PK
