MIC13_MACFA
ID MIC13_MACFA Reviewed; 118 AA.
AC Q2ACH7;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 34.
DE RecName: Full=MICOS complex subunit MIC13 {ECO:0000250|UniProtKB:Q5XKP0};
DE AltName: Full=Protein P117;
GN Name=MICOS13 {ECO:0000250|UniProtKB:Q5XKP0}; Synonyms=QIL1;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Takenaka A., Kawamoto S., Varavudhi P., Kawamoto Y., Suzuki J.,
RA Eakavibatha C., Terao K., Nakamura S., Hirai H., Takenaka O.;
RT "A novel retroposon P117 in the intergenic region of alpha-globin genes in
RT the macaques.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Constituent of mature
CC MICOS complex, it is required for the formation of cristae junction
CC (CJ) and maintenance of cristae morphology. Required for the
CC incorporation of MICOS10/MIC10 into the MICOS complex.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and
CC IMMT/MIC60. The complex associates with mitochondrial outer membrane
CC proteins SAMM50, MTX1 and MTX2, and with HSPA9.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5XKP0}; Single-pass membrane protein
CC {ECO:0000255}. Note=Enriched at crista junctions.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC {ECO:0000305}.
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DR EMBL; AB162658; BAE80090.1; -; Genomic_DNA.
DR RefSeq; XP_005587700.1; XM_005587643.2.
DR AlphaFoldDB; Q2ACH7; -.
DR STRING; 9541.XP_005587700.1; -.
DR Ensembl; ENSMFAT00000078010; ENSMFAP00000057897; ENSMFAG00000034498.
DR GeneID; 102138958; -.
DR KEGG; mcf:102138958; -.
DR CTD; 125988; -.
DR VEuPathDB; HostDB:ENSMFAG00000034498; -.
DR eggNOG; ENOG502S4BC; Eukaryota.
DR GeneTree; ENSGT00390000002629; -.
DR OMA; GIIKVMS; -.
DR Proteomes; UP000233100; Chromosome 19.
DR Bgee; ENSMFAG00000034498; Expressed in heart and 13 other tissues.
DR GO; GO:0061617; C:MICOS complex; ISS:UniProtKB.
DR GO; GO:0044284; C:mitochondrial crista junction; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR InterPro; IPR026769; Mic13.
DR PANTHER; PTHR31816; PTHR31816; 1.
DR Pfam; PF15884; QIL1; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..118
FT /note="MICOS complex subunit MIC13"
FT /id="PRO_0000289986"
FT TRANSMEM 8..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 13055 MW; 3E85872927651045 CRC64;
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP AVYQFSQYVC
QQTGLQIPQL PAPPKIYFPI RDSWNAGIMT VMSALSVAPS KAREYSKEGW EYVKARTK
