MIC13_MOUSE
ID MIC13_MOUSE Reviewed; 119 AA.
AC Q8R404;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=MICOS complex subunit MIC13 {ECO:0000250|UniProtKB:Q5XKP0};
GN Name=Micos13; Synonyms=Mic13, Qil1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=C57BL/6 X DBA, and C57BL/6J;
RA Xue Y.-Q., Tian Z.-S., Tu Y.-J., Yang P., Sun M.-Z., He Q., Qi Z.-H.;
RT "Novel gene identified from human APOE transgenic mice.";
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Constituent of mature
CC MICOS complex, it is required for the formation of cristae junction
CC (CJ) and maintenance of cristae morphology. Required for the
CC incorporation of MICOS10/MIC10 into the MICOS complex.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and
CC IMMT/MIC60. The MICOS complex associates with mitochondrial outer
CC membrane proteins SAMM50, MTX1 and MTX2 (together described as
CC components of the mitochondrial outer membrane sorting assembly
CC machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane
CC protein TMEM11 and with HSPA9. The MICOS and SAM complexes together
CC with DNAJC11 are part of a large protein complex spanning both
CC membranes termed the mitochondrial intermembrane space bridging (MIB)
CC complex. {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5XKP0}; Single-pass membrane protein
CC {ECO:0000255}. Note=Enriched at crista junctions.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC {ECO:0000305}.
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DR EMBL; AY091637; AAM14633.1; -; mRNA.
DR EMBL; AF501666; AAM22184.1; -; Genomic_DNA.
DR EMBL; AK075942; BAC36071.1; -; mRNA.
DR EMBL; AK075961; BAC36083.1; -; mRNA.
DR EMBL; BC056164; AAH56164.1; -; mRNA.
DR CCDS; CCDS28908.1; -.
DR RefSeq; NP_694792.1; NM_153152.3.
DR AlphaFoldDB; Q8R404; -.
DR BioGRID; 230339; 1.
DR IntAct; Q8R404; 2.
DR MINT; Q8R404; -.
DR STRING; 10090.ENSMUSP00000052908; -.
DR iPTMnet; Q8R404; -.
DR PhosphoSitePlus; Q8R404; -.
DR SwissPalm; Q8R404; -.
DR EPD; Q8R404; -.
DR jPOST; Q8R404; -.
DR MaxQB; Q8R404; -.
DR PaxDb; Q8R404; -.
DR PeptideAtlas; Q8R404; -.
DR PRIDE; Q8R404; -.
DR ProteomicsDB; 252552; -.
DR TopDownProteomics; Q8R404; -.
DR Antibodypedia; 49612; 27 antibodies from 13 providers.
DR DNASU; 224904; -.
DR Ensembl; ENSMUST00000052832; ENSMUSP00000052908; ENSMUSG00000049760.
DR GeneID; 224904; -.
DR KEGG; mmu:224904; -.
DR UCSC; uc008dcl.1; mouse.
DR CTD; 125988; -.
DR MGI; MGI:2442174; Micos13.
DR VEuPathDB; HostDB:ENSMUSG00000049760; -.
DR eggNOG; ENOG502S4BC; Eukaryota.
DR GeneTree; ENSGT00390000002629; -.
DR HOGENOM; CLU_152642_0_1_1; -.
DR InParanoid; Q8R404; -.
DR OMA; GIIKVMS; -.
DR OrthoDB; 1599526at2759; -.
DR PhylomeDB; Q8R404; -.
DR TreeFam; TF343386; -.
DR BioGRID-ORCS; 224904; 11 hits in 73 CRISPR screens.
DR ChiTaRS; Micos13; mouse.
DR PRO; PR:Q8R404; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8R404; protein.
DR Bgee; ENSMUSG00000049760; Expressed in right kidney and 262 other tissues.
DR Genevisible; Q8R404; MM.
DR GO; GO:0061617; C:MICOS complex; ISS:UniProtKB.
DR GO; GO:0044284; C:mitochondrial crista junction; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR InterPro; IPR026769; Mic13.
DR PANTHER; PTHR31816; PTHR31816; 1.
DR Pfam; PF15884; QIL1; 1.
PE 1: Evidence at protein level;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..119
FT /note="MICOS complex subunit MIC13"
FT /id="PRO_0000289987"
FT TRANSMEM 8..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 119 AA; 13373 MW; 4F8DED9CAAFEACDA CRC64;
MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSEAA LRKAEEVVPP AMYQFSQYVC
QQTGLEMPQL PTPPKIKFPN FRDSWNSGII SVMSALSVAP SKAREYSKEG WEYLKEHSK
