MIC13_PIG
ID MIC13_PIG Reviewed; 118 AA.
AC A1XQR7;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 25-MAY-2022, entry version 43.
DE RecName: Full=MICOS complex subunit MIC13 {ECO:0000250|UniProtKB:Q5XKP0};
GN Name=MICOS13 {ECO:0000250|UniProtKB:Q5XKP0}; Synonyms=QIL1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Longissimus dorsi muscle;
RA Cai G., Chen Y., Wang C., Li J., Peng G., Zhang H.;
RT "Generation and analysis of cDNA sequences derived from a porcine skeletal
RT muscle library.";
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Constituent of mature
CC MICOS complex, it is required for the formation of cristae junction
CC (CJ) and maintenance of cristae morphology. Required for the
CC incorporation of MICOS10/MIC10 into the MICOS complex.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex, composed of at least MICOS10/MIC10,
CC CHCHD3/MIC19, CHCHD6/MIC25, APOO/MIC26, MICOS13/MIC13, APOOL/MIC27 and
CC IMMT/MIC60. The MICOS complex associates with mitochondrial outer
CC membrane proteins SAMM50, MTX1 and MTX2 (together described as
CC components of the mitochondrial outer membrane sorting assembly
CC machinery (SAM) complex) and DNAJC11, mitochondrial inner membrane
CC protein TMEM11 and with HSPA9. The MICOS and SAM complexes together
CC with DNAJC11 are part of a large protein complex spanning both
CC membranes termed the mitochondrial intermembrane space bridging (MIB)
CC complex. {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q5XKP0}; Single-pass membrane protein
CC {ECO:0000255}. Note=Enriched at crista junctions.
CC {ECO:0000250|UniProtKB:Q5XKP0}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC {ECO:0000305}.
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DR EMBL; DQ629138; ABK55623.1; -; mRNA.
DR RefSeq; NP_001090932.1; NM_001097463.2.
DR AlphaFoldDB; A1XQR7; -.
DR STRING; 9823.ENSSSCP00000014371; -.
DR PaxDb; A1XQR7; -.
DR PeptideAtlas; A1XQR7; -.
DR PRIDE; A1XQR7; -.
DR GeneID; 100037978; -.
DR KEGG; ssc:100037978; -.
DR CTD; 125988; -.
DR eggNOG; ENOG502S4BC; Eukaryota.
DR InParanoid; A1XQR7; -.
DR OrthoDB; 1599526at2759; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0061617; C:MICOS complex; ISS:UniProtKB.
DR GO; GO:0044284; C:mitochondrial crista junction; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR InterPro; IPR026769; Mic13.
DR PANTHER; PTHR31816; PTHR31816; 1.
DR Pfam; PF15884; QIL1; 1.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..118
FT /note="MICOS complex subunit MIC13"
FT /id="PRO_0000289988"
FT TRANSMEM 8..26
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 118 AA; 13322 MW; 86E95C0979A55D77 CRC64;
MVPRVWSLMR FLIKGSVAGG AIYLVYDQDP LGPSDKSQAA LQKAEEVVPP AVYQFSQYVC
EQTGLKIPQL PAPPKFNFHI RDYWNSGVIK VMSALSVAPS KAREYSKEGW EYLKERTK
