ID   MIC19_EMENI             Reviewed;         209 AA.
AC   Q5ASP0;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=MICOS complex subunit mic19;
GN   ORFNames=AN8690;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
RN   [3]
RP   INDUCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17258477; DOI=10.1016/j.fgb.2006.12.001;
RA   Kim Y., Nandakumar M.P., Marten M.R.;
RT   "Proteome map of Aspergillus nidulans during osmoadaptation.";
RL   Fungal Genet. Biol. 44:886-895(2007).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane (By similarity).
CC       Involved in osmoadaptation. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}; Intermembrane side
CC       {ECO:0000250}.
CC   -!- INDUCTION: Down-regulated when grown with elevated levels of potassium
CC       chloride. {ECO:0000269|PubMed:17258477}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA60239.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AACD01000160; EAA60239.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BN001303; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_681959.1; XM_676867.1.
DR   AlphaFoldDB; Q5ASP0; -.
DR   SMR; Q5ASP0; -.
DR   STRING; 227321.Q5ASP0; -.
DR   PRIDE; Q5ASP0; -.
DR   EnsemblFungi; EAA60239; EAA60239; AN8690.2.
DR   GeneID; 2868585; -.
DR   KEGG; ani:AN8690.2; -.
DR   VEuPathDB; FungiDB:AN8690; -.
DR   HOGENOM; CLU_093897_0_0_1; -.
DR   InParanoid; Q5ASP0; -.
DR   Proteomes; UP000000560; Chromosome III.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0071470; P:cellular response to osmotic stress; IEP:AspGD.
DR   InterPro; IPR012471; DUF1690.
DR   Pfam; PF07956; DUF1690; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Stress response.
FT   CHAIN           1..209
FT                   /note="MICOS complex subunit mic19"
FT                   /id="PRO_0000363399"
FT   COILED          48..86
FT                   /evidence="ECO:0000255"
FT   COILED          127..156
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   209 AA;  22867 MW;  51EB8E81E77679D3 CRC64;
     MGAGSSKPEA SAGSKHIFES NSPIQFSSNL VDGLQSNTET DSARAKSLEL EIQNRVAKEL
     ERLRAREQQT LAEIEKRLSE AKDTGSFASA PSAPAVTHYP AGSLDLDAPR IPFAGREYAP
     PPPAAVEVAA VNKELNRESV NSEIEELRVK LEGRKKLAEL DEGVAKAQKD VVSCLRLNDR
     RPLDCWKEVA EFKKEVARLE EGFVDRIVG