MIC25_XENTR
ID MIC25_XENTR Reviewed; 253 AA.
AC Q5FVV3; A8KBD0; Q0VA68;
DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=MICOS complex subunit mic25;
DE AltName: Full=Coiled-coil-helix-coiled-coil-helix domain-containing protein 6;
GN Name=chchd6; Synonyms=mic25;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane.
CC {ECO:0000250|UniProtKB:Q9BRQ6}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex (also known as MINOS or MitOS
CC complex). {ECO:0000250|UniProtKB:Q9BRQ6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BRQ6}; Lipid-anchor
CC {ECO:0000250|UniProtKB:Q9BRQ6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5FVV3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5FVV3-2; Sequence=VSP_042998;
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic19 family. Metazoan
CC Mic25 subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH89756.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI21226.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAI54065.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AAMC01078073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078074; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078075; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078076; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078077; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078078; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078079; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078081; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078084; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01078086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC089756; AAH89756.1; ALT_INIT; mRNA.
DR EMBL; BC121225; AAI21226.1; ALT_INIT; mRNA.
DR EMBL; BC154064; AAI54065.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q5FVV3; -.
DR SMR; Q5FVV3; -.
DR STRING; 8364.ENSXETP00000019879; -.
DR PaxDb; Q5FVV3; -.
DR eggNOG; KOG4083; Eukaryota.
DR HOGENOM; CLU_049040_2_1_1; -.
DR InParanoid; Q5FVV3; -.
DR TreeFam; TF326279; -.
DR Proteomes; UP000008143; Genome assembly.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0042407; P:cristae formation; ISS:UniProtKB.
DR GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central.
DR InterPro; IPR007964; MIC19/MIC25.
DR Pfam; PF05300; MIC19_MIC25; 1.
DR PROSITE; PS51808; CHCH; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Disulfide bond; Lipoprotein; Membrane;
KW Mitochondrion; Mitochondrion inner membrane; Myristate; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255"
FT CHAIN 2..253
FT /note="MICOS complex subunit mic25"
FT /id="PRO_0000416913"
FT DOMAIN 206..248
FT /note="CHCH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT REGION 1..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 94..178
FT /evidence="ECO:0000255"
FT MOTIF 209..219
FT /note="Cx9C motif 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT MOTIF 230..240
FT /note="Cx9C motif 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT COMPBIAS 11..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 2
FT /note="N-myristoyl glycine"
FT /evidence="ECO:0000255"
FT DISULFID 209..240
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT DISULFID 219..230
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01150"
FT VAR_SEQ 149
FT /note="L -> LPADLDEW (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_042998"
SQ SEQUENCE 253 AA; 28395 MW; E24B95AE43B048A6 CRC64;
MGGSESTGRK VSFGMDEEER VRVLRGVRLS DEVVNRMKDS DLPSKDQSTS AASGTASAPA
AFPSKAGPSA SHPASTSTGG AHKPTAAGVG QQYAEEDLYR RYEREQAIIQ EELARLAKRE
RESAHEKLSA SILLEKNSTN QERRKAEHLA KELEQKEAEL QRLNTFYREQ LSSIEKKNLE
IYRLTAEQYH TAATNAELRV RQRSYDPVCM NLQADILKCY SENKQERLNC SNLAKEYRKC
VSAAQKNLLF NHG
