ID   MIC27_ASHGO             Reviewed;         236 AA.
AC   Q755Y8;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=MICOS complex subunit MIC27;
GN   Name=MIC27; OrderedLocusNames=AER379C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein O/MICOS complex subunit Mic27
CC       family. {ECO:0000305}.
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DR   EMBL; AE016818; AAS53059.1; -; Genomic_DNA.
DR   RefSeq; NP_985235.1; NM_210589.1.
DR   AlphaFoldDB; Q755Y8; -.
DR   SMR; Q755Y8; -.
DR   STRING; 33169.AAS53059; -.
DR   EnsemblFungi; AAS53059; AAS53059; AGOS_AER379C.
DR   GeneID; 4621451; -.
DR   KEGG; ago:AGOS_AER379C; -.
DR   eggNOG; ENOG502S31N; Eukaryota.
DR   HOGENOM; CLU_093584_0_0_1; -.
DR   InParanoid; Q755Y8; -.
DR   OMA; KYKVCKG; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0000329; C:fungal-type vacuole membrane; IEA:EnsemblFungi.
DR   GO; GO:0061617; C:MICOS complex; IEA:EnsemblFungi.
DR   GO; GO:0044284; C:mitochondrial crista junction; IEA:EnsemblFungi.
DR   GO; GO:0042407; P:cristae formation; IEA:EnsemblFungi.
DR   GO; GO:0043933; P:protein-containing complex organization; IEA:EnsemblFungi.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..236
FT                   /note="MICOS complex subunit MIC27"
FT                   /id="PRO_0000399832"
FT   TOPO_DOM        1..96
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..113
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..145
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..165
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        166..236
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   236 AA;  26628 MW;  B9C08899825FA154 CRC64;
     MSRNFYNYDP TVDILQPPLI PDVILKSNLK ELTLPTGNQV LESLPLTAWF HRTRSNIISH
     LTRYEAEWET QKSAARNELH SVKSYLKGNI FNDARELYAL PETNILTICA YFAGRIITNR
     KNWGVSAATL QSVKSSVHRP SLMARVCTSI PSKMVLPWAM AGAVFKELAP TAFDNTITSL
     ESDILDPGFV AQYKTLWRDY YTNGAKKASI EAAELLEGKL QGYIGFARNF IIYSTR