ID   MIC27_CANGA             Reviewed;         238 AA.
AC   Q6FSZ7;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=MICOS complex subunit MIC27;
GN   Name=MIC27; OrderedLocusNames=CAGL0G06600g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein O/MICOS complex subunit Mic27
CC       family. {ECO:0000305}.
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DR   EMBL; CR380953; CAG59574.1; -; Genomic_DNA.
DR   RefSeq; XP_446647.1; XM_446647.1.
DR   AlphaFoldDB; Q6FSZ7; -.
DR   SMR; Q6FSZ7; -.
DR   STRING; 5478.XP_446647.1; -.
DR   EnsemblFungi; CAG59574; CAG59574; CAGL0G06600g.
DR   GeneID; 2887984; -.
DR   KEGG; cgr:CAGL0G06600g; -.
DR   CGD; CAL0130755; CAGL0G06600g.
DR   VEuPathDB; FungiDB:CAGL0G06600g; -.
DR   eggNOG; ENOG502S31N; Eukaryota.
DR   HOGENOM; CLU_093584_0_0_1; -.
DR   InParanoid; Q6FSZ7; -.
DR   Proteomes; UP000002428; Chromosome G.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="MICOS complex subunit MIC27"
FT                   /id="PRO_0000399833"
FT   TOPO_DOM        1..103
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        125..141
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        163..238
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  27515 MW;  C97014664402C155 CRC64;
     MVNFYGDSIG EKVEDGDKVR TERLFTESKE IPTVKVSDLP SGYKVLQIPE VTERIGEYRN
     KFLKYYERTY VKISEYKARK KNELDDRVQY LKKNIFVDKY ENEELLAPIS LLGLGAFFTG
     RILTNPTNWG YGALLIKGQP TFFGMFMSSV PARIILPIFL AGYTFNKFLP VTSSKFVETC
     ERDVLPKNVT KAIKDSKRQL YTEGLVNTRK TISQAVYRNC EDAVHRVRMS IAEQLDKW