MIC27_LACTC
ID MIC27_LACTC Reviewed; 240 AA.
AC C5DGX3;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=MICOS complex subunit MIC27;
GN Name=MIC27; OrderedLocusNames=KLTH0D09020g;
OS Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS (Yeast) (Kluyveromyces thermotolerans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Lachancea.
OX NCBI_TaxID=559295;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the apolipoprotein O/MICOS complex subunit Mic27
CC family. {ECO:0000305}.
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DR EMBL; CU928168; CAR22665.1; -; Genomic_DNA.
DR RefSeq; XP_002553103.1; XM_002553057.1.
DR AlphaFoldDB; C5DGX3; -.
DR SMR; C5DGX3; -.
DR STRING; 559295.C5DGX3; -.
DR EnsemblFungi; CAR22665; CAR22665; KLTH0D09020g.
DR GeneID; 8295340; -.
DR KEGG; lth:KLTH0D09020g; -.
DR eggNOG; ENOG502S31N; Eukaryota.
DR HOGENOM; CLU_093584_0_0_1; -.
DR InParanoid; C5DGX3; -.
DR OMA; KYKVCKG; -.
DR OrthoDB; 1392736at2759; -.
DR Proteomes; UP000002036; Chromosome D.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
PE 3: Inferred from homology;
KW Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..240
FT /note="MICOS complex subunit MIC27"
FT /id="PRO_0000399835"
FT TOPO_DOM 1..100
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..156
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 157..176
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 177..240
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
SQ SEQUENCE 240 AA; 26812 MW; A202472AB2D62375 CRC64;
MSRNFYADEG AFVGSSKGPL LPDILHTEDV STKTLPTGNQ IYDSKALDSW FSGIRKYVTH
KYYIYKTELD TQKSAAANEW KSVQDYVSQH VLTDDYEKQE LLVPSSALAL GAFFTGRVLS
NRRNWGFDSP LNTTKAGILT RNPSALGRVL TSIPSRVLLP WVLTGTVLSQ LTPVTWNNSV
KALEQDVLPA DLVARYHEIW NQLLVDGVQK TSASVHRNVD ASLQQGIGEV RRYLVKKLDL
