ID   MIC27_VANPO             Reviewed;         260 AA.
AC   A7TN96;
DT   02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=MICOS complex subunit MIC27;
GN   Name=MIC27; ORFNames=Kpol_505p4;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein O/MICOS complex subunit Mic27
CC       family. {ECO:0000305}.
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DR   EMBL; DS480429; EDO16228.1; -; Genomic_DNA.
DR   RefSeq; XP_001644086.1; XM_001644036.1.
DR   AlphaFoldDB; A7TN96; -.
DR   SMR; A7TN96; -.
DR   STRING; 436907.A7TN96; -.
DR   EnsemblFungi; EDO16228; EDO16228; Kpol_505p4.
DR   GeneID; 5544402; -.
DR   KEGG; vpo:Kpol_505p4; -.
DR   eggNOG; ENOG502S31N; Eukaryota.
DR   HOGENOM; CLU_093584_0_0_1; -.
DR   InParanoid; A7TN96; -.
DR   OrthoDB; 1392736at2759; -.
DR   PhylomeDB; A7TN96; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Hydrogen ion transport; Ion transport; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..260
FT                   /note="MICOS complex subunit MIC27"
FT                   /id="PRO_0000399836"
FT   TOPO_DOM        1..126
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..169
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        190..260
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   260 AA;  29599 MW;  8C44834CF0F39890 CRC64;
     MIFDYLYCKP VKEVVPKGSA PVDDLNHELV KTIDKIDDNV DNAAIVESNG SQWNDVVKYR
     LSDDVEITGS EQLTESIRGW RLNIVDELDK LRSKWDTGKQ EMYDKKTDTN AFLNDNVFNN
     KFENEELVVP SVFLSFGAFC SGRILSNPKN WGHSKTGSLT AVRSGLLYKS LTNLPSRLLL
     PWIFAGYTFS QFSPKTFDNI CKVVEEDLLP PAFAKSCRDN WNSIYVNGIK KHSQGLSSSI
     DENLQNSIRS IREFIYKSLY