MIC60_ASPCL
ID MIC60_ASPCL Reviewed; 628 AA.
AC A1CHB5;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 25-MAY-2022, entry version 55.
DE RecName: Full=MICOS complex subunit mic60;
DE AltName: Full=Mitofilin;
DE Flags: Precursor;
GN Name=mic60; ORFNames=ACLA_047390;
OS Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS NRRL 1 / QM 1276 / 107).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=344612;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT fumigatus.";
RL PLoS Genet. 4:E1000046-E1000046(2008).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Plays a role in
CC keeping cristae membranes connected to the inner boundary membrane.
CC Also promotes protein import via the mitochondrial intermembrane space
CC assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC {ECO:0000305}.
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DR EMBL; DS027054; EAW10270.1; -; Genomic_DNA.
DR RefSeq; XP_001271696.1; XM_001271695.1.
DR AlphaFoldDB; A1CHB5; -.
DR SMR; A1CHB5; -.
DR STRING; 5057.CADACLAP00004406; -.
DR EnsemblFungi; EAW10270; EAW10270; ACLA_047390.
DR GeneID; 4704330; -.
DR KEGG; act:ACLA_047390; -.
DR VEuPathDB; FungiDB:ACLA_047390; -.
DR eggNOG; KOG1854; Eukaryota.
DR HOGENOM; CLU_008024_1_2_1; -.
DR OMA; LQGWAKV; -.
DR OrthoDB; 1540241at2759; -.
DR Proteomes; UP000006701; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR PANTHER; PTHR15415; PTHR15415; 1.
DR Pfam; PF09731; Mitofilin; 2.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..41
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 42..628
FT /note="MICOS complex subunit mic60"
FT /id="PRO_0000406644"
FT TOPO_DOM 42..99
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..628
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 44..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 301..444
FT /evidence="ECO:0000255"
FT COMPBIAS 48..65
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 77..92
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..247
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 628 AA; 69979 MW; CF4014BD2EF23FCE CRC64;
MLRSSITQSR QLLLSPARSR TASQWLPRAG ASNRISGQRF FADVKPPVVP GAPTPASPSS
DTPIPPETVP KSTLADEATL PPPPPPPPAP VRKTGRFRRF LIYLILTSGF AYGGGIFLAM
KSDNFHDFFT EYVPYGEDCV LYFEERDFYR RFPNTLRNAN RAPKDEGNKV TIPSKSGLSW
KVAEEESGAD LSAKGPHMSA VEQKGDEAQI KPGTAKPEEK VAAVEKAKSD KPVKEEAPKD
TTKVQEEPRK PAVPAVTPIE FATVNEGDEA VVQELVKTFN DIITVIGADE SAHKFSGTII
KAKDELQKIG EKIIAIRDEA RNAAQEEIKE AHATFDESAR ELIRRFEEAR ASDAAQYREE
FELEREKLAH AYQEKIRTEL LRAQEVAEQR LQNELVEQAI ELNRKYLHEV KDLVEREREG
RLSKLNELTT NVTELEKLTT DWKEVIDTNL KTQQLQVAVD AVRSVLERST VPRPFVRELV
AVKELAAEDP VVEAAIASIN PTAYQRGIPS TAQIIERFRR VADEVRKASL LPEDAGIASH
AASLVLSKVM FKKDAVAGSD DVESILIRTE SLLEEGNIDA AAREMNTLKG WAKILSKDWL
GDVRRVLEVK QALEVIETEA RLQCLRVE
