ID   MIC60_ASPFC             Reviewed;         624 AA.
AC   B0Y5Z6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=MICOS complex subunit mic60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=mic60; ORFNames=AFUB_065130;
OS   Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus
OS   fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=451804;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CEA10 / CBS 144.89 / FGSC A1163;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; DS499598; EDP50181.1; -; Genomic_DNA.
DR   AlphaFoldDB; B0Y5Z6; -.
DR   SMR; B0Y5Z6; -.
DR   EnsemblFungi; EDP50181; EDP50181; AFUB_065130.
DR   HOGENOM; CLU_008024_1_2_1; -.
DR   PhylomeDB; B0Y5Z6; -.
DR   Proteomes; UP000001699; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 1.
DR   Pfam; PF09731; Mitofilin; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..41
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..624
FT                   /note="MICOS complex subunit mic60"
FT                   /id="PRO_0000406645"
FT   TOPO_DOM        42..96
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        118..624
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          42..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          180..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          295..440
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        64..89
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..246
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   624 AA;  69525 MW;  9FAE6B206F25B61E CRC64;
     MLRSSFTQSR QLLLSQARSR TAAQWLPKAG ASNRLAGQRF FADAKPPVTG APTPASPSSE
     SSIPPETVPK PSPAAEAPLP PPPPPAPARK TGRFRKFLLY LILTSGFAYG GGIFLALKSD
     NFHDFFTEYV PYGEDCVLYF EERDFYRRFP NTLRNQNRAP KDEGHTVTIP SKSGLSWKVA
     EEESGADVSQ KGPHMSALDN GDKAQLKPGA AKPEEKVATV EKVKAESAAK EQTAEDKKKV
     KEEPKKPAAP AVTPIEFATV SEGDEEVVQE LVKTFNDIIT VIGADENAHK FSGAVNKAKE
     ELRTIGEKII AIRNEARKAA QEEIKQAHAT FDESARELIR RFEEARAHDA AQYREEFEAE
     RERLARAYQE KVNTELQRAQ EVAEQRLKNE LVEQAIELNR KYLHEVKDLV EREREGRLSK
     LNELTANVNL LEKLTTDWKE VIDTNLKTQQ LQVAVDAVRS VLERSTVPRP FVRELVAVKE
     LAAGDPVVEA AIASINPTAY QRGIPSTSQI IERFRRVADE VRKASLLPED AGIASHAASL
     VLSKVMFKKD AVAGSDDVES VLLRTEHLLE EGNLDDAARE MNTLKGWAKI LSKDWLSDVR
     RVLEVKQALE VRLGPFTSLF HLYR