MIC60_ASPFU
ID MIC60_ASPFU Reviewed; 624 AA.
AC Q4WP49;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 75.
DE RecName: Full=MICOS complex subunit mic60;
DE AltName: Full=Mitofilin;
DE Flags: Precursor;
GN Name=mic60; ORFNames=AFUA_4G08030;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Plays a role in
CC keeping cristae membranes connected to the inner boundary membrane.
CC Also promotes protein import via the mitochondrial intermembrane space
CC assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC {ECO:0000305}.
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DR EMBL; AAHF01000005; EAL89985.1; -; Genomic_DNA.
DR RefSeq; XP_752023.1; XM_746930.1.
DR AlphaFoldDB; Q4WP49; -.
DR SMR; Q4WP49; -.
DR STRING; 746128.CADAFUBP00006338; -.
DR EnsemblFungi; EAL89985; EAL89985; AFUA_4G08030.
DR GeneID; 3508926; -.
DR KEGG; afm:AFUA_4G08030; -.
DR eggNOG; KOG1854; Eukaryota.
DR HOGENOM; CLU_008024_1_2_1; -.
DR InParanoid; Q4WP49; -.
DR OMA; LQGWAKV; -.
DR OrthoDB; 1540241at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR PANTHER; PTHR15415; PTHR15415; 1.
DR Pfam; PF09731; Mitofilin; 2.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..41
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 42..624
FT /note="MICOS complex subunit mic60"
FT /id="PRO_0000406646"
FT TOPO_DOM 42..96
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 118..624
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 42..89
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 295..440
FT /evidence="ECO:0000255"
FT COMPBIAS 64..89
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 208..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 69525 MW; 9FAE6B206F25B61E CRC64;
MLRSSFTQSR QLLLSQARSR TAAQWLPKAG ASNRLAGQRF FADAKPPVTG APTPASPSSE
SSIPPETVPK PSPAAEAPLP PPPPPAPARK TGRFRKFLLY LILTSGFAYG GGIFLALKSD
NFHDFFTEYV PYGEDCVLYF EERDFYRRFP NTLRNQNRAP KDEGHTVTIP SKSGLSWKVA
EEESGADVSQ KGPHMSALDN GDKAQLKPGA AKPEEKVATV EKVKAESAAK EQTAEDKKKV
KEEPKKPAAP AVTPIEFATV SEGDEEVVQE LVKTFNDIIT VIGADENAHK FSGAVNKAKE
ELRTIGEKII AIRNEARKAA QEEIKQAHAT FDESARELIR RFEEARAHDA AQYREEFEAE
RERLARAYQE KVNTELQRAQ EVAEQRLKNE LVEQAIELNR KYLHEVKDLV EREREGRLSK
LNELTANVNL LEKLTTDWKE VIDTNLKTQQ LQVAVDAVRS VLERSTVPRP FVRELVAVKE
LAAGDPVVEA AIASINPTAY QRGIPSTSQI IERFRRVADE VRKASLLPED AGIASHAASL
VLSKVMFKKD AVAGSDDVES VLLRTEHLLE EGNLDDAARE MNTLKGWAKI LSKDWLSDVR
RVLEVKQALE VRLGPFTSLF HLYR
