ID   MIC60_CANAL             Reviewed;         567 AA.
AC   Q5A044; A0A1D8PSI1; Q59ZZ2;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2017, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=MICOS complex subunit MIC60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=MIC60; Synonyms=FMP13; OrderedLocusNames=CAALFM_CR03530WA;
GN   ORFNames=CaO19.11874, CaO19.4396;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; CP017630; AOW31091.1; -; Genomic_DNA.
DR   RefSeq; XP_715172.2; XM_710079.2.
DR   AlphaFoldDB; Q5A044; -.
DR   SMR; Q5A044; -.
DR   STRING; 237561.Q5A044; -.
DR   PRIDE; Q5A044; -.
DR   GeneID; 3643204; -.
DR   KEGG; cal:CAALFM_CR03530WA; -.
DR   CGD; CAL0000200955; orf19.11874.
DR   VEuPathDB; FungiDB:CR_03530W_A; -.
DR   eggNOG; KOG1854; Eukaryota.
DR   HOGENOM; CLU_008024_2_0_1; -.
DR   InParanoid; Q5A044; -.
DR   OrthoDB; 1540241at2759; -.
DR   PRO; PR:Q5A044; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IDA:CGD.
DR   GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 2.
DR   Pfam; PF09731; Mitofilin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..567
FT                   /note="MICOS complex subunit MIC60"
FT                   /id="PRO_0000406648"
FT   TOPO_DOM        26..64
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        65..87
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        88..567
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          31..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          284..383
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   567 AA;  62702 MW;  87B44335F4B24BD8 CRC64;
     MIRITSRSVK GAAGIRSVSS STVRLNIAPK VVSPPVPPPV KPQGSEIPPP PPPPPPPPKA
     KRFSLFGFLF KTTLLATVVY GGTLYAATKN DKVMDFVIDK QLPFHEELID LIENGSTEDL
     QEAWEQLKNK FTDVKLPTKD DIDELTQKLE HRGEDIIKET KKKIASTHIG HKSGTDLTPT
     EQLQRGVEIE SVKKDVAHLP LIELNSDLGK SVDETVKQTI TSFNNFIQSI DASSLATKDD
     KLITSINTSV NQLASRLNSL TKDFDNELQN KLKVSQTELF SSFTKKELEL TENLLHQFST
     EKQQLEAKLN QKLSQEIQAA RAAISQAASN AVAMVRIEQT KNFEKLVSEK LNEERNGRLA
     NLEKLNDRIV ELEKFAEGFE TQIVSNHKKA IIHQAVSKLK SLLLAPAAGD KPQPIKPYID
     ELTKIATDDE VLALAIKDLS PLITNESTHS ILTNAQLLSR WEQLAPELRS ASLLPPNAGL
     LGHLASIVFS KLLLPVKGVK EDGKDIESVI GRVESSLARG ELDIAVEEAA NLKGWSRKLA
     NDWVVEGRKR LEIEFLLGLI ESESKII