ID   MIC60_CANAW             Reviewed;         565 AA.
AC   C4YLH0;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=MICOS complex subunit MIC60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=MIC60; ORFNames=CAWG_01688;
OS   Candida albicans (strain WO-1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294748;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WO-1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; CM000309; EEQ43451.1; -; Genomic_DNA.
DR   AlphaFoldDB; C4YLH0; -.
DR   STRING; 5476.C4YLH0; -.
DR   EnsemblFungi; EEQ43451; EEQ43451; CAWG_01688.
DR   VEuPathDB; FungiDB:CAWG_01688; -.
DR   HOGENOM; CLU_008024_2_0_1; -.
DR   OMA; LQGWAKV; -.
DR   Proteomes; UP000001429; Chromosome R.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 2.
DR   Pfam; PF09731; Mitofilin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..565
FT                   /note="MICOS complex subunit MIC60"
FT                   /id="PRO_0000406649"
FT   TOPO_DOM        26..62
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        63..85
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        86..565
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          34..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          282..381
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   565 AA;  62596 MW;  08B8A419B90AA3B8 CRC64;
     MIRITSRSVK EAAGIRSVSS STVRLNIAPK VVSPPVPPPV KPQGSEIPPP PPPPPLKAKR
     FSLFGFLFKT TLLATVVYGG TLYAATKNDK VMDFVIDKQL PFHEELIDLI ENGSTEDLQE
     AWEQLKNKFT DVKLPTKDDI DELTQKLEHR GEDIIKETKK KIASTHIGHK SGTDLTPTEQ
     LQRGVEIESV KKDVAHLPLI ELNSDLGKSV DETVKQTITS FNNFIQSIDA SSLATKDDKL
     ITSINTSVNQ LASRLNSLTK DFDNELQNKL KVSQTELFSS FTKKELELTE NLLHQFSTEK
     QQLEAKLNQK LSQEIQAARA AISQAASNAV AMVRIEQTKN FEKLVSEKLN EERNGRLANL
     EKLNDRIVEL EKFAEGFETQ IVSNHKKAII HQAVSKLKSL LLAPAAGDKP QPIKPYIDEL
     TKIATDDEVL ALAIKDLSPL ITNESTHSIL TNAQLLSRWE QLAPELRSAS LLPPNAGLLG
     HLASIVFSKL LLPVKGVKED GKDIESVIGR VESSLARGEL DIAVEEAANL KGWSRKLAND
     WVVEGRKRLE IEFLLGLIES ESKII