MIC60_CANGA
ID MIC60_CANGA Reviewed; 520 AA.
AC Q6FSU7;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=MICOS complex subunit MIC60;
DE AltName: Full=Mitofilin;
DE Flags: Precursor;
GN Name=MIC60; OrderedLocusNames=CAGL0G07711g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Plays a role in
CC keeping cristae membranes connected to the inner boundary membrane.
CC Also promotes protein import via the mitochondrial intermembrane space
CC assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC {ECO:0000305}.
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DR EMBL; CR380953; CAG59624.1; -; Genomic_DNA.
DR RefSeq; XP_446697.1; XM_446697.1.
DR AlphaFoldDB; Q6FSU7; -.
DR SMR; Q6FSU7; -.
DR STRING; 5478.XP_446697.1; -.
DR EnsemblFungi; CAG59624; CAG59624; CAGL0G07711g.
DR GeneID; 2888151; -.
DR KEGG; cgr:CAGL0G07711g; -.
DR CGD; CAL0130717; CAGL0G07711g.
DR VEuPathDB; FungiDB:CAGL0G07711g; -.
DR eggNOG; KOG1854; Eukaryota.
DR HOGENOM; CLU_008024_2_0_1; -.
DR InParanoid; Q6FSU7; -.
DR Proteomes; UP000002428; Chromosome G.
DR GO; GO:0061617; C:MICOS complex; IEA:EnsemblFungi.
DR GO; GO:0030061; C:mitochondrial crista; IEA:EnsemblFungi.
DR GO; GO:0044284; C:mitochondrial crista junction; IEA:EnsemblFungi.
DR GO; GO:0042407; P:cristae formation; IEA:EnsemblFungi.
DR GO; GO:0045041; P:protein import into mitochondrial intermembrane space; IEA:EnsemblFungi.
DR InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR PANTHER; PTHR15415; PTHR15415; 2.
DR Pfam; PF09731; Mitofilin; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..20
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 21..520
FT /note="MICOS complex subunit MIC60"
FT /id="PRO_0000406651"
FT TOPO_DOM 21..42
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 43..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..520
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT COILED 176..325
FT /evidence="ECO:0000255"
SQ SEQUENCE 520 AA; 59193 MW; 9935D585431F285C CRC64;
MLRTKITGSS HVLRTAFKRY SSTIDSGAVE VVKPKKTSFT RRLFRLGLAV TAFYAGGVAV
SQYDDDLGTL FTEKVPGAEK LVDSYVTYRY DPTISKMLST EYLLNLFKGE NTEVKPSTSS
RLVPIHDAIK ELHLELLELD SENNSEPEMQ KIINSLNSTI NMINEQKLRI GGKKSRSIEE
NYKQLIEDIL HLDKNLKETV SKSINEKTEE VVKKVREQYK RKLAVSEVEL QDKYKNEFIH
LKEEMEKHYQ DILNQKLEAN KQHLEAKHAN EIALLSITQV SEFNKIIKEK VDSERNGRLA
KIEDLDKKAE NLTEALKHVN KVVTRNEAVK QIAQQIEIIR SKLNSHDLNS ISLHDDLTRL
RTLTDIAVPG PKPCCKHKDL TPSLFRVALD ELESVAGSSE SKILSEEQIY NRWNLLESDF
KTASLLPPNA GMLGHFTAKL FSLFLFTKRG SALPDATDLD SVFARINENL RHSKLDKAVA
DVVTLKGWTH VLCDDWLKNA RRKLEVEKLV DVLDSELKSL