ID   MIC60_CANTT             Reviewed;         567 AA.
AC   C5M3V6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=MICOS complex subunit MIC60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=MIC60; ORFNames=CTRG_00745;
OS   Candida tropicalis (strain ATCC MYA-3404 / T1) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=294747;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-3404 / T1;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG692395; EER36006.1; -; Genomic_DNA.
DR   RefSeq; XP_002545964.1; XM_002545918.1.
DR   AlphaFoldDB; C5M3V6; -.
DR   SMR; C5M3V6; -.
DR   STRING; 5482.XP_002545964.1; -.
DR   EnsemblFungi; EER36006; EER36006; CTRG_00745.
DR   GeneID; 8297270; -.
DR   KEGG; ctp:CTRG_00745; -.
DR   VEuPathDB; FungiDB:CTRG_00745; -.
DR   eggNOG; KOG1854; Eukaryota.
DR   HOGENOM; CLU_008024_2_0_1; -.
DR   OrthoDB; 1540241at2759; -.
DR   Proteomes; UP000002037; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 2.
DR   Pfam; PF09731; Mitofilin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..567
FT                   /note="MICOS complex subunit MIC60"
FT                   /id="PRO_0000406652"
FT   TOPO_DOM        26..68
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        92..567
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          36..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          284..383
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        39..63
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   567 AA;  62754 MW;  70F8405D025B2BD8 CRC64;
     MIRIAARNAN RSTAIRSIST TSIRLNTTQK VVVTPPPVAT EGELPPPQPK VTPPKATPPP
     PPKTKRFSLF GFLLKTTLLA SVVYGGTLYA ATKNDKVMDF VVDNRLPYHE ELLELIETGS
     IDDLQQGLDQ LKSKFGSVKL PSKEEIDELA QKLEHKGEDI IKETKKKFTA TRTGTDLTPS
     EQLQKGVEIE SVKKDVPHLP LIELNSELGS SVDETVKQTI ASFNNFIQTI DASTLASKND
     KLIASINFSI SQLASKLNGL TKSFDEELQK KLKVSQTELF SSFTKKELEL TENLLHQFTT
     EKQQLEAKLN EKLNQEIQAS RTAISQAATN AVSMVRIEQT KNFEKLVTEK LNEERNGRLA
     NLDKLNDRLT ELEKFAEGFE TQIVSNHKKA LIQQAVSKLK SLLLAPAANE KPKSIKPYVD
     ELSKIAADDE VLKLALKDLT PLLSNESTHS ILTNAQLLSR WEQLAPELRS ASLLPPNAGL
     LGHLASIVFS KLLLPVKGVK QDGKDIESVI GRVESSLARG ELDVAVEEAA NLKGWSRKLA
     NDWVVEGRKR LEVEFLLGLI ESESKII