MIC60_NEUCR
ID MIC60_NEUCR Reviewed; 672 AA.
AC Q7SFD8;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=MICOS complex subunit mic60;
DE AltName: Full=Mitofilin;
DE Flags: Precursor;
GN Name=mic60; ORFNames=B13C5.200, NCU00894;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Plays a role in
CC keeping cristae membranes connected to the inner boundary membrane.
CC Also promotes protein import via the mitochondrial intermembrane space
CC assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC {ECO:0000305}.
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DR EMBL; BX842682; CAE82004.1; -; Genomic_DNA.
DR EMBL; CM002236; EAA35574.1; -; Genomic_DNA.
DR RefSeq; XP_964810.1; XM_959717.2.
DR AlphaFoldDB; Q7SFD8; -.
DR SMR; Q7SFD8; -.
DR STRING; 5141.EFNCRP00000000742; -.
DR EnsemblFungi; EAA35574; EAA35574; NCU00894.
DR GeneID; 3880934; -.
DR KEGG; ncr:NCU00894; -.
DR VEuPathDB; FungiDB:NCU00894; -.
DR HOGENOM; CLU_008024_1_2_1; -.
DR InParanoid; Q7SFD8; -.
DR Proteomes; UP000001805; Chromosome 1, Linkage Group I.
DR GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR PANTHER; PTHR15415; PTHR15415; 1.
DR Pfam; PF09731; Mitofilin; 1.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..48
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 49..672
FT /note="MICOS complex subunit mic60"
FT /id="PRO_0000406662"
FT TOPO_DOM 49..125
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 126..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 149..672
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 43..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 189..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 403..489
FT /evidence="ECO:0000255"
FT COMPBIAS 65..79
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..112
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 73443 MW; 1CEE9A06B75C65FC CRC64;
MLRTSLRSVR ALGSRPSAAV AGRQWQATVV RRAAVSGQRF FADDKKPVVP EPSQPAVLPA
SETLTSPSTP PPASPQVEPT STVPPETTPL TPPTPEATVI PPVAEEPVVP PTLPTPRKKK
GFFRRLRNFF LSLTILGAIA FGGGVYYSRI NDAFHDFFTE YIPYGEQAVL YLEELDFKKR
FPDVVSRVTG RPRDSGEQVK VPAQSGASWR VASGGEPAGR QSSSIKKAGA AAQDAVPKSE
PAVVAAAKED TAELPKTEAT TTATPAEPAP APAATDASGT PVKKPFKAPE VDEPSRWPPA
SPIDPLTVNG ATDPIVQDLV KMLNDVITVI NHDNANEKYA PTICKAKNEL SKVADKINEM
KAKVEADAAK QVKARVDGFD KAANELVSRV ESAMAAQEAA WRREFEEEIT RLKKSYDEKV
HLIQDREHQI AEEKLNNRLL EQAIQLQRQF TENIKKHVEQ ERDGRLGKLN ELHKAVAELE
RLTSGLNEVV DTNLRTQQLH VAVDAVRASL EDAHHPRPFI KELVALKEIA ADDPVVDAAI
ASINPTAYQR GIPTTAELID RFRRVATEVR KASLLPEDAG VASHASSYVL SKLMFKKEGL
AAGDDVESIL TRTQTYLEEG DLDNAAREMN GLKGWAKTLS RDWLGEVRKV LEVQQALDVI
QAEARLQSLR VE
