ID   MIC60_PARBP             Reviewed;         685 AA.
AC   C0RYV1;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   04-FEB-2015, sequence version 2.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=MICOS complex subunit MIC60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=MIC60; ORFNames=PABG_00606;
OS   Paracoccidioides brasiliensis (strain Pb03).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenales incertae sedis; Paracoccidioides.
OX   NCBI_TaxID=482561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Pb03;
RX   PubMed=22046142; DOI=10.1371/journal.pgen.1002345;
RA   Desjardins C.A., Champion M.D., Holder J.W., Muszewska A., Goldberg J.,
RA   Bailao A.M., Brigido M.M., Ferreira M.E., Garcia A.M., Grynberg M.,
RA   Gujja S., Heiman D.I., Henn M.R., Kodira C.D., Leon-Narvaez H.,
RA   Longo L.V.G., Ma L.-J., Malavazi I., Matsuo A.L., Morais F.V., Pereira M.,
RA   Rodriguez-Brito S., Sakthikumar S., Salem-Izacc S.M., Sykes S.M.,
RA   Teixeira M.M., Vallejo M.C., Walter M.E., Yandava C., Young S., Zeng Q.,
RA   Zucker J., Felipe M.S., Goldman G.H., Haas B.J., McEwen J.G., Nino-Vega G.,
RA   Puccia R., San-Blas G., Soares C.M., Birren B.W., Cuomo C.A.;
RT   "Comparative genomic analysis of human fungal pathogens causing
RT   paracoccidioidomycosis.";
RL   PLoS Genet. 7:E1002345-E1002345(2011).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; KN305531; EEH18043.2; -; Genomic_DNA.
DR   AlphaFoldDB; C0RYV1; -.
DR   SMR; C0RYV1; -.
DR   EnsemblFungi; EEH18043; EEH18043; PABG_00606.
DR   VEuPathDB; FungiDB:PABG_00606; -.
DR   HOGENOM; CLU_008024_1_2_1; -.
DR   InParanoid; C0RYV1; -.
DR   Proteomes; UP000002740; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 1.
DR   Pfam; PF09731; Mitofilin; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..19
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..685
FT                   /note="MICOS complex subunit MIC60"
FT                   /id="PRO_0000406665"
FT   TOPO_DOM        20..149
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        150..169
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        170..685
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          49..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          356..456
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        49..100
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..144
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  74965 MW;  90759D6B2B388AD3 CRC64;
     MLRTSIATSR QLLSSPVCPK ASAQWLRSSN AGRANTTTRR YYAIQQEPNG ALRSSLSPSA
     AAVSDVSQRA SNSTNTKRPN TSDLNVRSPA SPSTGSTLKP ETVLVAPVSP LRQGQSSPGS
     AAPAPEPAAA PPPSPPPPPP APKTGRLRKF LLYLFLTTGL AYAGGVWYSL RSDNFYDFFT
     EYAPYGENAV IYLEERDFRN RFPNATKKNN RRAVAPRDEG AQVTIPGGSG LSWKVAEEQQ
     EGSDISKKGP HMSAVDNNKA TKDTKTVEKT KGGVTSKSPA QKEEAVMTKP APEGVKTQPA
     KVAETPREPA IPAITTIDHL VLNTEDEPVV QDLVKVFNDI ITVISADAPS SFSGPVAKAK
     EELEKIGKRI LALKSDAQAS AQKEINDAHA SFDKSAANLI RHIDEMRAED ATKFREEFEA
     ERERIAQSYQ EKINTELQRA HEVAEQRLRN ELVEQAIELN RKFLSDVKNL VEHERESRLS
     KLAELVSSVA ELERLTAGWS DVIDINLKTQ QLQVAVDAVR TTLENSNVPR PFIRELAAVK
     ELASNDEVVS AAIDSISPVA YQRGIPSSAH LVDRFRRVAT EVRKASLLPE NAGITSHAAS
     FVLNKVMLKK HGSPAGNDVE STLTRAENFL EEGNLDEAAR EMNSLKGWAK LLSKDWLADV
     RRVLEVKQAL EVIETEARLR CLQVE