MIC60_SCHPO
ID MIC60_SCHPO Reviewed; 550 AA.
AC O59725;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=MICOS complex subunit mic60;
DE AltName: Full=Mitofilin;
DE Flags: Precursor;
GN Name=mic60; ORFNames=SPBC3E7.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC the mitochondrial inner membrane that plays crucial roles in the
CC maintenance of crista junctions, inner membrane architecture, and
CC formation of contact sites to the outer membrane. Plays a role in
CC keeping cristae membranes connected to the inner boundary membrane.
CC Also promotes protein import via the mitochondrial intermembrane space
CC assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC organizing system (MICOS) complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA19009.1; -; Genomic_DNA.
DR PIR; T40379; T40379.
DR RefSeq; NP_596092.1; NM_001022008.2.
DR AlphaFoldDB; O59725; -.
DR SMR; O59725; -.
DR BioGRID; 277550; 6.
DR STRING; 4896.SPBC3E7.05c.1; -.
DR TCDB; 9.B.216.1.2; the micos complex component, mic60 (mic60) family.
DR MaxQB; O59725; -.
DR PaxDb; O59725; -.
DR EnsemblFungi; SPBC3E7.05c.1; SPBC3E7.05c.1:pep; SPBC3E7.05c.
DR GeneID; 2541035; -.
DR KEGG; spo:SPBC3E7.05c; -.
DR PomBase; SPBC3E7.05c; mic60.
DR VEuPathDB; FungiDB:SPBC3E7.05c; -.
DR eggNOG; KOG1854; Eukaryota.
DR HOGENOM; CLU_492713_0_0_1; -.
DR InParanoid; O59725; -.
DR PhylomeDB; O59725; -.
DR PRO; PR:O59725; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0061617; C:MICOS complex; ISO:PomBase.
DR GO; GO:0044284; C:mitochondrial crista junction; ISO:PomBase.
DR GO; GO:0005739; C:mitochondrion; HDA:PomBase.
DR GO; GO:0042407; P:cristae formation; ISO:PomBase.
DR InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR PANTHER; PTHR15415; PTHR15415; 2.
DR Pfam; PF09731; Mitofilin; 2.
PE 3: Inferred from homology;
KW Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..38
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 39..550
FT /note="MICOS complex subunit mic60"
FT /id="PRO_0000372365"
FT TOPO_DOM 39..66
FT /note="Mitochondrial matrix"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..86
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..550
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT REGION 35..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 214..275
FT /evidence="ECO:0000255"
FT COMPBIAS 131..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 550 AA; 63215 MW; 4158CE9752745674 CRC64;
MNRQLRTVKS CFSLQKTHQY RSFWIQSSLR ALPPDVKQNK TEPIPFVPKP EEGSSNKSNS
SKFRKRFLLL FLLGITGYSC SVVYCFKDPN FYDYFAEHTP FGKQVLYNVE QSWIGYKYLG
GNRIKVDDSS PKLKQNSNNI SKKQNSSRND DTKVKKDTTI ERPESLVVEI VDLPSEVTKD
TAEESVWKDI GLDQETGLSV TAIPIITETL DHAHEQEIKD QSLRFESSLN EANELHGKLS
KIQQEQEHLF EQRLREKVSE MESKLEALLI ARDEKWQSAF ESEKLRLQKL HEARLQQELF
KLASVFESKL KNELTEQAIT LEKLHLQSIK AQVEQERGSR LGRLQELRNS FQQLQELVRV
VLHENGRVTR LVDVSNTLDD LNKDMRFHKL SEVRQHVNTL KEATKDDELA ALASRVIEKI
VDSGPILDKE ELQTKFDTLS KEIYKTCFLT TESGFFGHLK SIILSQLPAA VFKSPDIVSV
KKTLEDARSH LLKDDLDGSV RALLSLSQWP RALSRDWINA CRRRMELQQA IEIIKASATL
SSQLEDAQQA
