ID   MIC60_TALMQ             Reviewed;         643 AA.
AC   B6QHK6;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=MICOS complex subunit mic60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=mic60; ORFNames=PMAA_094570;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; DS995902; EEA22851.1; -; Genomic_DNA.
DR   RefSeq; XP_002149018.1; XM_002148982.1.
DR   AlphaFoldDB; B6QHK6; -.
DR   SMR; B6QHK6; -.
DR   STRING; 441960.B6QHK6; -.
DR   EnsemblFungi; EEA22851; EEA22851; PMAA_094570.
DR   GeneID; 7026575; -.
DR   KEGG; tmf:PMAA_094570; -.
DR   VEuPathDB; FungiDB:PMAA_094570; -.
DR   HOGENOM; CLU_008024_1_2_1; -.
DR   OrthoDB; 1540241at2759; -.
DR   PhylomeDB; B6QHK6; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 1.
DR   Pfam; PF09731; Mitofilin; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..42
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           43..643
FT                   /note="MICOS complex subunit mic60"
FT                   /id="PRO_0000406667"
FT   TOPO_DOM        43..116
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        117..137
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        138..643
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          44..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          173..263
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          317..451
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        61..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..109
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..257
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  71081 MW;  0212FB8F09E83851 CRC64;
     MLRYSVLSSQ TRLLSASRQR TATQLLANPI ASNRIITGQR YFADHKNVPP TSPTPVSPES
     QSVIPPQTVN PVTATPTAQV QTSPPSSIQP PKPPVETPSS SPIPPPTPKK TGRFRRFLLY
     LILTSGIAYG GGVFLALKSD NFHDFFTEYV PYGEESVLYF EERDFYRRFP NATRHSNRLP
     PIHKEQSQRV TIPSKSGLSW KVSEEESDSA SLTQKGPHNS AVDASKDASA VKTVIKAKEE
     SAEKKAPVKK EAAPPAPKEE PRTPAIATPA TLELIKVEGA DEPVVQELVR IFNDIITVIG
     ADEGAATKYA APVSRVRTEV ETIGQKISSL RADAEKAAKE EVEKAHALFD ESAKKLMQQI
     EQARAAEAAQ FREEFEAERE KLVRAYQEKI QTELSRAQEL AEQRLKNELV EQAIELNRKY
     LNDVKELVER ERDGRLSKIS ELTANVNQLE KLTTDWSDVI ESNLKTQQLQ VAVDAVRSVL
     EGATSAKPFI RELVAVKELA ADDPVVAAAI ASINPTAYQR GIPTSSQLIE RFRRVAGEVR
     KASLLPEDAG IASHAASFVL SKVMFKRDAV TDGDDVESVL VRTENLLEEG NLDAAAREMN
     TLQGWAKILS KDWLADVRRV LEVKQAVELM ETEARLQCLR VES