ID   MIC60_YARLI             Reviewed;         563 AA.
AC   Q6C060;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=MICOS complex subunit MIC60;
DE   AltName: Full=Mitofilin;
DE   Flags: Precursor;
GN   Name=MIC60; OrderedLocusNames=YALI0F27555g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex of
CC       the mitochondrial inner membrane that plays crucial roles in the
CC       maintenance of crista junctions, inner membrane architecture, and
CC       formation of contact sites to the outer membrane. Plays a role in
CC       keeping cristae membranes connected to the inner boundary membrane.
CC       Also promotes protein import via the mitochondrial intermembrane space
CC       assembly (MIA) pathway (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic60 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382132; CAG78764.1; -; Genomic_DNA.
DR   RefSeq; XP_505952.1; XM_505952.1.
DR   AlphaFoldDB; Q6C060; -.
DR   SMR; Q6C060; -.
DR   STRING; 4952.CAG78764; -.
DR   PRIDE; Q6C060; -.
DR   EnsemblFungi; CAG78764; CAG78764; YALI0_F27555g.
DR   GeneID; 2909051; -.
DR   KEGG; yli:YALI0F27555g; -.
DR   VEuPathDB; FungiDB:YALI0_F27555g; -.
DR   HOGENOM; CLU_008024_1_2_1; -.
DR   InParanoid; Q6C060; -.
DR   OMA; LQGWAKV; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0061617; C:MICOS complex; IBA:GO_Central.
DR   GO; GO:0042407; P:cristae formation; IBA:GO_Central.
DR   InterPro; IPR019133; Mt-IM_prot_Mitofilin.
DR   PANTHER; PTHR15415; PTHR15415; 2.
DR   Pfam; PF09731; Mitofilin; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT   TRANSIT         1..17
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..563
FT                   /note="MICOS complex subunit MIC60"
FT                   /id="PRO_0000406679"
FT   TOPO_DOM        18..68
FT                   /note="Mitochondrial matrix"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        90..563
FT                   /note="Mitochondrial intermembrane"
FT                   /evidence="ECO:0000255"
FT   REGION          23..59
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          128..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          178..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          239..379
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        23..41
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        150..165
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   563 AA;  59881 MW;  C23E87E392E26C6C CRC64;
     MIRATAMHRS IVQRRMLSTA SRLQQAAKPA TGSTVGTANG ASAASGKPPG ATFEGASKQK
     KKTHKFRNFV LLSTFVGAGA FAGGVYYSLQ NDQFQSLFVE YVPAAEHAIN YIEEQQLRSG
     RLKIATPTSK HDVDQSTVRV PKSGATWRAV DSTDAATSAK SASSPAANVA KDVASPAPAA
     TASPVSSGSP KTDNTTVPAV RLANDSDPAV KAAVQTFNDL IAVAPSGAAK QLSAKVSTVV
     DQLQHNVAQI KSEAAEEAKN SINKLNSELA KLKASTGEEI SSKVSAAEQQ LRNEFAALRA
     HSEKVYHDRL RVEIEATKSL VSSHANNLIQ AVEAERQKQY AQEIAERVET EREGRLSKLK
     DLQTSLTQLQ DLALKTEQAV DASGRTAALH LAIAKLTGAL KGSEPVALGP YVESIRRAAG
     DDPLLQAALD SIPEVAQTEG VLTPAQLTIR FKLLEPELRK SSLVPVNAGV AGHLGSLIFS
     SLLFKKSGVP KGDDVESVLA RANIALEQGK LYDAVAEVNT LKGWPRKLAS DWLDEGRRRT
     EIEFLADVIA EEGKLYGALS SKK