MICA_HUMAN
ID MICA_HUMAN Reviewed; 383 AA.
AC Q29983; A8KQR0; A9LRW5; A9QVE0; B1VJF1; O60917; O60918; O60919; O60920;
AC O60933; O77956; O78150; O78151; O78152; O78153; O97987; O97988; O97989;
AC O97990; O97991; O97992; O97993; O97994; O97995; O98234; O98235; O98236;
AC O98237; O98238; P79506; P79507; P79508; P79509; P79510; P79511; P79512;
AC P79513; P79514; P79515; P79516; P79517; P79518; P79519; P79520; P79521;
AC Q5C9P8; Q5XM81; Q70I48; Q70I49; Q7JFH9; Q7JFI0; Q7JFI1; Q7JFI2; Q7YQ98;
AC Q861I1; Q95464; Q95HA2; Q95HD6; Q95HN4; Q95HN5; Q95HN6; Q95IB2; Q95IY7;
AC Q99692; Q9BCR3; Q9BCR4; Q9BCR5; Q9BCR6; Q9BCR7; Q9BCR8; Q9BCR9; Q9BCS0;
AC Q9BCS1; Q9BCS2; Q9BCS3; Q9BCS4; Q9BD20; Q9GIZ1; Q9GIZ2; Q9GIZ3; Q9GIZ4;
AC Q9GIZ5; Q9GIZ6; Q9GJ01; Q9GJ02; Q9GJ03; Q9GJ04; Q9GJ05; Q9GJ06; Q9GJ07;
AC Q9GJ08; Q9GJ09; Q9MY21; Q9TQ86; Q9TQ87; Q9TQ88; Q9TQ89; Q9TQ92; Q9TQ93;
AC Q9TQ94; Q9TQ95; Q9TQ96; Q9TQ97; Q9TQ98; Q9TQ99; Q9TQA0; Q9TQA1; Q9TQA2;
AC Q9TQA3; Q9TQA4; Q9TQI9; Q9TQJ0; Q9TQJ1; Q9TQJ9; Q9TQK0; Q9TQK1; Q9TQK2;
AC Q9TQK8; Q9TQK9; Q9TQL0; Q9TQL1; Q9TQL2; Q9TQL3; Q9TQL4; Q9UE04; Q9UE05;
AC Q9UE06; Q9UE11;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=MHC class I polypeptide-related sequence A;
DE Short=MIC-A;
DE Flags: Precursor;
GN Name=MICA {ECO:0000312|EMBL:CAI41907.1};
GN Synonyms=PERB11.1 {ECO:0000303|PubMed:8613147};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA21718.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ALLELE MICA*001).
RX PubMed=8022771; DOI=10.1073/pnas.91.14.6259;
RA Bahram S., Bresnahan M., Geraghty D.E., Spies T.;
RT "A second lineage of mammalian major histocompatibility complex class I
RT genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 91:6259-6263(1994).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAA63427.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ALLELE MICA*004).
RX PubMed=8613147; DOI=10.1007/bf02602661;
RA Bahram S., Mizuki N., Inoko H., Spies T.;
RT "Nucleotide sequence of the human MHC class I MICA gene.";
RL Immunogenetics 44:80-81(1996).
RN [3] {ECO:0000312|EMBL:CAI41907.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELES MICA*001 AND
RP MICA*004).
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [4] {ECO:0000305, ECO:0000312|EMBL:AAH16929.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE MICA*018), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 70-248 (ISOFORM 2).
RC TISSUE=Bone, and Kidney {ECO:0000312|EMBL:AAH16929.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150 (ALLELES MICA*001; MICA*008 AND
RP MICA*010).
RX PubMed=7927538; DOI=10.1007/bf01246675;
RA Leelayuwat C., Townend D.C., Degli-Esposti M.A., Abraham L.J.,
RA Dawkins R.L.;
RT "A new polymorphic and multicopy MHC gene family related to nonmammalian
RT class I.";
RL Immunogenetics 40:339-351(1994).
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAB41069.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*001; MICA*002;
RP MICA*004; MICA*005; MICA*006; MICA*007; MICA*008; MICA*009; MICA*010;
RP MICA*011; MICA*012; MICA*013; MICA*014; MICA*015 AND MICA*016).
RX PubMed=8781120; DOI=10.1007/bf02602779;
RA Fodil N., Laloux L., Wanner V., Pellet P., Hauptmann G., Mizuki N.,
RA Inoko H., Spies T., Theodorou I., Bahram S.;
RT "Allelic repertoire of the human MHC class I MICA gene.";
RL Immunogenetics 44:351-357(1996).
RN [7] {ECO:0000305, ECO:0000312|EMBL:CAA76395.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*007; MICA*008;
RP MICA*009; MICA*010; MICA*012; MICA*016; MICA*017; MICA*018; MICA*022;
RP MICA*024; MICA*025; MICA*028 AND MICA*029).
RX PubMed=10331160; DOI=10.1046/j.1365-2370.1999.00094.x;
RA Yao Z., Volgger A., Helmberg W., Keller E., Fan L.A., Chandanayingyong D.,
RA Albert E.D.;
RT "Definition of new alleles of MIC-A using sequencing-based typing.";
RL Eur. J. Immunogenet. 26:225-232(1999).
RN [8] {ECO:0000305, ECO:0000312|EMBL:AAD27009.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELES MICA*009; MICA*017;
RP MICA*018 AND MICA*019).
RX PubMed=10380703; DOI=10.1007/s002510050536;
RA Fodil N., Pellet P., Laloux L., Hauptmann G., Theodorou I., Bahram S.;
RT "MICA haplotypic diversity.";
RL Immunogenetics 49:557-560(1999).
RN [9] {ECO:0000305, ECO:0000312|EMBL:BAA29034.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*019).
RX PubMed=10369920; DOI=10.1007/s002510050658;
RA Komatsu-Wakui M., Tokunaga K., Ishikawa Y., Kashiwase K., Moriyama S.,
RA Tsuchiya N., Ando H., Shiina T., Geraghty D.E., Inoko H., Juji T.;
RT "MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype.";
RL Immunogenetics 49:620-628(1999).
RN [10] {ECO:0000305, ECO:0000312|EMBL:CAD91415.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-297 (ALLELE MICA*051).
RC TISSUE=Blood {ECO:0000312|EMBL:CAD91415.1};
RX PubMed=15104678; DOI=10.1111/j.0001-2815.2004.00195.x;
RA Quiroga I., Sweeney D., Sutton P.M., Chapple S.D., Souto-Grando J.P.,
RA Barnardo M.C.N.M., Fuggle S.V.;
RT "Identification of a novel MICA allele: MICA*051.";
RL Tissue Antigens 63:466-469(2004).
RN [11] {ECO:0000305, ECO:0000312|EMBL:AAD01476.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*008; MICA*023 AND
RP MICA*028), AND NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES
RP MICA*001; MICA*002; MICA*004; MICA*006; MICA*007; MICA*009; MICA*010;
RP MICA*011; MICA*016; MICA*018; MICA*019; MICA*022; MICA*024; MICA*025;
RP MICA*026; MICA*027; MICA*031; MICA*032; MICA*033; MICA*034; MICA*035;
RP MICA*036; MICA*037; MICA*038; MICA*039 AND MICA*040).
RX PubMed=10380704; DOI=10.1007/s002510050537;
RA Visser C.J.T., Tilanus M.G.J., Tatari Z., van der Zwan A.-W., Bakker R.,
RA Rozemuller E.H., Schaeffer V., Tamouza R., Charron D.;
RT "Sequencing-based typing of MICA reveals 33 alleles: a study on linkage
RT with classical HLA genes.";
RL Immunogenetics 49:561-566(1999).
RN [12] {ECO:0000305, ECO:0000312|EMBL:AAK19623.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-383 (ALLELES MICA*001; MICA*002;
RP MICA*006; MICA*008; MICA*009; MICA*010; MICA*011; MICA*012; MICA*015;
RP MICA*016; MICA*017; MICA*018; MICA*019; MICA*048 AND MICA*049).
RX PubMed=11556982; DOI=10.1034/j.1399-0039.2001.057006520.x;
RA Obuchi N., Takahashi M., Nouchi T., Satoh M., Arimura T., Ueda K., Akai J.,
RA Ota M., Naruse T., Inoko H., Numano F., Kimura A.;
RT "Identification of MICA alleles with a long Leu-repeat in the transmembrane
RT region and no cytoplasmic tail due to a frameshift-deletion in exon 4.";
RL Tissue Antigens 57:520-535(2001).
RN [13] {ECO:0000305, ECO:0000312|EMBL:CAC27561.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELES MICA*008; MICA*017;
RP MICA*018; MICA*019; MICA*027; MICA*029; MICA*033; MICA*041; MICA*043;
RP MICA*045 AND MICA*046).
RX PubMed=11841487; DOI=10.1046/j.0960-7420.2001.00275.x;
RA Perez-Rodriguez M., Arguello J.R., Fischer G., Corell A., Cox S.T.,
RA Robinson J., Hossain E., McWhinnie A., Travers P.J., Marsh S.G.E.,
RA Madrigal J.A.;
RT "Further polymorphism of the MICA gene.";
RL Eur. J. Immunogenet. 29:35-46(2002).
RN [14] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-371 (ALLELE MICA*008).
RA Kaur G., Shiina T., Hashimoto N., Kumar N., Inoko H., Mehra N.K.;
RT "MIC-A sequence in AH8.2.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN [15] {ECO:0000305, ECO:0000312|EMBL:CAB71317.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*020).
RX PubMed=10746789; DOI=10.1034/j.1399-0039.2000.550209.x;
RA Perez-Rodriguez M., Corell A., Fischer G., Arguello R., Cox S.T.,
RA McWhinnie A., Marsh S.G.E., Madrigal A.;
RT "A new MICA allele with ten alanine residues in the exon 5
RT microsatellite.";
RL Tissue Antigens 55:162-165(2000).
RN [16] {ECO:0000305, ECO:0000312|EMBL:CAC88121.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*047).
RX PubMed=12074712; DOI=10.1034/j.1399-0039.2002.590306.x;
RA Perez-Rodriguez M., Raimondi E., Marsh S.G.E., Madrigal J.A.;
RT "Identification of a new MICA allele, MICA*047.";
RL Tissue Antigens 59:216-218(2002).
RN [17] {ECO:0000305, ECO:0000312|EMBL:CAE45582.2}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELES MICA*007; MICA*018 AND
RP MICA*053).
RX PubMed=16634869; DOI=10.1111/j.1399-0039.2006.00574.x;
RA Quiroga I., Sweeney D., Sutton P.M., Ahmad T., Walton R.,
RA Barnardo M.C.N.M., Fuggle S.V.;
RT "The identification of three novel MICA alleles by sequence-based typing.";
RL Tissue Antigens 67:321-325(2006).
RN [18] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*052).
RA Mas V., Amezaga N., Arostegui J.I., Masso M., Plaza S., Rius F.,
RA Ercilla G., Vives J., Yague J.;
RT "Description of a new MICA allele.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [19] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*054).
RC TISSUE=Blood {ECO:0000312|EMBL:CAP12057.1};
RA Cox S.T.;
RT "Description of a novel MICA allele, MICA*010v, discovered by sequencing
RT based typing.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [20] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*055).
RA Glas J., Maier K., Wetzke M., Henninger M., Euba A., Weiss E.H.,
RA Folwaczny M.;
RT "MICA*TM A8: a new allele with eight GCT repeats in the exon 5
RT microsatellite.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [21] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-341 (ALLELE MICA*056).
RA Cox S.T.;
RT "Sequence of new MICA allele, similar to MICA*019.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [22] {ECO:0000305, ECO:0000312|EMBL:AAC28944.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*009; MICA*017;
RP MICA*018; MICA*019 AND MICA*030).
RX PubMed=10369917; DOI=10.1007/s002510050655;
RA Petersdorf E.W., Shuler K.B., Longton G.M., Spies T., Hansen J.A.;
RT "Population study of allelic diversity in the human MHC class I-related
RT MIC-A gene.";
RL Immunogenetics 49:605-612(1999).
RN [23] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-297 (ALLELES MICA*008; MICA*012;
RP MICA*041; MICA*042; MICA*043; MICA*044 AND MICA*045).
RA Hirose T., Mitsuishi Y., Young C.;
RT "New alleles of human non-classical class I MICA gene.";
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [24] {ECO:0000305, ECO:0000312|EMBL:AAV39504.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-283 (ALLELE MICA*019).
RA Yan L., Zhu F.;
RT "Identification of a novel MICA allele by SBT.";
RL Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
RN [25] {ECO:0000305, ECO:0000312|EMBL:AAM34484.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 299-341 (ALLELE MICA*050).
RX PubMed=12542746; DOI=10.1034/j.1399-0039.2002.600608.x;
RA Rueda B., Pascual M., Lopez-Nevot M.A., Gonzalez E., Martin J.;
RT "A new allele within the transmembrane region of the human MICA gene with
RT seven GCT repeats.";
RL Tissue Antigens 60:526-528(2002).
RN [26] {ECO:0000305}
RP SUBUNIT, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, AND
RP GLYCOSYLATION.
RX PubMed=8901601; DOI=10.1073/pnas.93.22.12445;
RA Groh V., Bahram S., Bauer S., Herman A., Beauchamp M., Spies T.;
RT "Cell stress-regulated human major histocompatibility complex class I gene
RT expressed in gastrointestinal epithelium.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:12445-12450(1996).
RN [27] {ECO:0000305}
RP SUBUNIT, AND TISSUE SPECIFICITY.
RX PubMed=9396860; DOI=10.1007/s002510050339;
RA Zwirner N.W., Fernandez-Vina M.A., Stastny P.;
RT "MICA, a new polymorphic HLA-related antigen, is expressed mainly by
RT keratinocytes, endothelial cells, and monocytes.";
RL Immunogenetics 47:139-148(1998).
RN [28] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=9497295; DOI=10.1126/science.279.5357.1737;
RA Groh V., Steinle A., Bauer S., Spies T.;
RT "Recognition of stress-induced MHC molecules by intestinal epithelial
RT gammadelta T cells.";
RL Science 279:1737-1740(1998).
RN [29] {ECO:0000305}
RP INVOLVEMENT IN PSORIATIC ARTHRITIS SUSCEPTIBILITY.
RX PubMed=10323458;
RX DOI=10.1002/1529-0131(199905)42:5<1010::aid-anr21>3.0.co;2-h;
RA Gonzalez S., Martinez-Borra J., Torre-Alonso J.C., Gonzalez-Roces S.,
RA Sanchez del Rio J., Rodriguez Perez A., Brautbar C., Lopez-Larrea C.;
RT "The MICA-A9 triplet repeat polymorphism in the transmembrane region
RT confers additional susceptibility to the development of psoriatic arthritis
RT and is independent of the association of Cw*0602 in psoriasis.";
RL Arthritis Rheum. 42:1010-1016(1999).
RN [30] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10363723; DOI=10.1016/s0198-8859(98)00128-1;
RA Zwirner N.W., Dole K., Stastny P.;
RT "Differential surface expression of MICA by endothelial cells, fibroblasts,
RT keratinocytes, and monocytes.";
RL Hum. Immunol. 60:323-330(1999).
RN [31] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=10359807; DOI=10.1073/pnas.96.12.6879;
RA Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H., Spies T.;
RT "Broad tumor-associated expression and recognition by tumor-derived gamma
RT delta T cells of MICA and MICB.";
RL Proc. Natl. Acad. Sci. U.S.A. 96:6879-6884(1999).
RN [32] {ECO:0000305}
RP FUNCTION, AND INTERACTION WITH KLRK1.
RX PubMed=10426993; DOI=10.1126/science.285.5428.727;
RA Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L., Spies T.;
RT "Activation of NK cells and T cells by NKG2D, a receptor for stress-
RT inducible MICA.";
RL Science 285:727-729(1999).
RN [33] {ECO:0000305}
RP SUBUNIT.
RX PubMed=10426994; DOI=10.1126/science.285.5428.730;
RA Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L.,
RA Phillips J.H.;
RT "An activating immunoreceptor complex formed by NKG2D and DAP10.";
RL Science 285:730-732(1999).
RN [34] {ECO:0000305}
RP TISSUE SPECIFICITY, AND ASSOCIATION WITH PSORIASIS.
RX PubMed=10691930; DOI=10.1046/j.1365-2249.2000.01140.x;
RA Tay G.K., Hui J., Gaudieri S., Schmitt-Egenolf M., Martinez O.P.,
RA Leelayuwat C., Williamson J.F., Eiermann T.H., Dawkins R.L.;
RT "PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single
RT nucleotide polymorphisms are associated with psoriasis.";
RL Clin. Exp. Immunol. 119:553-558(2000).
RN [35] {ECO:0000305}
RP IDENTIFICATION AS AN ALLOANTIGEN.
RX PubMed=11053635; DOI=10.1016/s0198-8859(00)00162-2;
RA Zwirner N.W., Marcos C.Y., Mirbaha F., Zou Y., Stastny P.;
RT "Identification of MICA as a new polymorphic alloantigen recognized by
RT antibodies in sera of organ transplant recipients.";
RL Hum. Immunol. 61:917-924(2000).
RN [36]
RP FUNCTION AS A LIGAND FOR KLRK1.
RX PubMed=11777960; DOI=10.4049/jimmunol.168.2.671;
RA Sutherland C.L., Chalupny N.J., Schooley K., VandenBos T., Kubin M.,
RA Cosman D.;
RT "UL16-binding proteins, novel MHC class I-related proteins, bind to NKG2D
RT and activate multiple signaling pathways in primary NK cells.";
RL J. Immunol. 168:671-679(2002).
RN [37]
RP INTERACTION WITH HHV-5 PROTEIN UL142 (MICROBIAL INFECTION).
RX PubMed=19793804; DOI=10.1128/jvi.01175-09;
RA Ashiru O., Bennett N.J., Boyle L.H., Thomas M., Trowsdale J., Wills M.R.;
RT "NKG2D ligand MICA is retained in the cis-Golgi apparatus by human
RT cytomegalovirus protein UL142.";
RL J. Virol. 83:12345-12354(2009).
RN [38] {ECO:0000305}
RP VARIANT PRO-29.
RX PubMed=10752636; DOI=10.1007/s002510050039;
RA Li Z., Groh V., Strong R.K., Spies T.;
RT "A single amino acid substitution causes loss of expression of a MICA
RT allele.";
RL Immunogenetics 51:246-248(2000).
RN [39] {ECO:0000305}
RP INDUCTION.
RX PubMed=11485740; DOI=10.1016/s1074-7613(01)00168-6;
RA Das H., Groh V., Kuijl C., Sugita M., Morita C.T., Spies T., Bukowski J.F.;
RT "MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-
RT dependent effector function.";
RL Immunity 15:83-93(2001).
RN [40] {ECO:0000305}
RP FUNCTION, INTERACTION WITH KLRK1, AND EFFECT OF VARIANT VAL-152 ON BINDING
RP TO KLRK1.
RX PubMed=11491531; DOI=10.1007/s002510100325;
RA Steinle A., Li P., Morris D.L., Groh V., Lanier L.L., Strong R.K.,
RA Spies T.;
RT "Interactions of human NKG2D with its ligands MICA, MICB, and homologs of
RT the mouse RAE-1 protein family.";
RL Immunogenetics 53:279-287(2001).
RN [41] {ECO:0000305}
RP FUNCTION AS A LIGAND FOR KLRK1, AND INDUCTION.
RX PubMed=11224526; DOI=10.1038/85321;
RA Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R.,
RA Spies T.;
RT "Costimulation of CD8alphabeta T cells by NKG2D via engagement by MIC
RT induced on virus-infected cells.";
RL Nat. Immunol. 2:255-260(2001).
RN [42] {ECO:0000305}
RP ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
RX PubMed=12466900; DOI=10.1007/s00251-002-0496-y;
RA Zou Y., Stastny P.;
RT "Alternatively spliced forms of MICA and MICB lacking exon 3 in a human
RT cell line and evidence of presence of similar RNA in human peripheral blood
RT mononuclear cells.";
RL Immunogenetics 54:671-674(2002).
RN [43] {ECO:0000305}
RP PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
RX PubMed=12370336; DOI=10.4049/jimmunol.169.8.4098;
RA Salih H.R., Rammensee H.-G., Steinle A.;
RT "Down-regulation of MICA on human tumors by proteolytic shedding.";
RL J. Immunol. 169:4098-4102(2002).
RN [44] {ECO:0000305}
RP PROTEOLYTIC CLEAVAGE ON TUMOR CELLS.
RX PubMed=12384702; DOI=10.1038/nature01112;
RA Groh V., Wu J., Yee C., Spies T.;
RT "Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell
RT activation.";
RL Nature 419:734-738(2002).
RN [45] {ECO:0000305}
RP INDUCTION.
RX PubMed=11830641; DOI=10.1073/pnas.032668099;
RA Tieng V., Le Bouguenec C., du Merle L., Bertheau P., Desreumaux P.,
RA Janin A., Charron D., Toubert A.;
RT "Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface
RT expression of the MHC class I-related molecule MICA.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2977-2982(2002).
RN [46] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=12902493; DOI=10.4049/jimmunol.171.4.1909;
RA Hue S., Monteiro R.C., Berrih-Aknin S., Caillat-Zucman S.;
RT "Potential role of NKG2D/MHC class I-related chain A interaction in
RT intrathymic maturation of single-positive CD8 T cells.";
RL J. Immunol. 171:1909-1917(2003).
RN [47] {ECO:0000305}
RP INDUCTION.
RX PubMed=15995699; DOI=10.1038/nature03884;
RA Gasser S., Orsulic S., Brown E.J., Raulet D.H.;
RT "The DNA damage pathway regulates innate immune system ligands of the NKG2D
RT receptor.";
RL Nature 436:1186-1190(2005).
RN [48] {ECO:0000305}
RP INDUCTION.
RX PubMed=16750166; DOI=10.1016/j.bbrc.2006.05.092;
RA Chalupny N.J., Rein-Weston A., Dosch S., Cosman D.;
RT "Down-regulation of the NKG2D ligand MICA by the human cytomegalovirus
RT glycoprotein UL142.";
RL Biochem. Biophys. Res. Commun. 346:175-181(2006).
RN [49] {ECO:0000305}
RP INTERACTION WITH PDIA6.
RX PubMed=17495932; DOI=10.1038/nature05768;
RA Kaiser B.K., Yim D., Chow I.-T., Gonzalez S., Dai Z., Mann H.H.,
RA Strong R.K., Groh V., Spies T.;
RT "Disulphide-isomerase-enabled shedding of tumour-associated NKG2D
RT ligands.";
RL Nature 447:482-486(2007).
RN [50] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=17565371; DOI=10.1371/journal.pone.0000518;
RA Schrambach S., Ardizzone M., Leymarie V., Sibilia J., Bahram S.;
RT "In vivo expression pattern of MICA and MICB and its relevance to auto-
RT immunity and cancer.";
RL PLoS ONE 2:E518-E518(2007).
RN [51] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=18287244; DOI=10.1128/jvi.02251-07;
RA McSharry B.P., Burgert H.-G., Owen D.P., Stanton R.J., Prod'homme V.,
RA Sester M., Koebernick K., Groh V., Spies T., Cox S.T., Little A.-M.,
RA Wang E.C.Y., Tomasec P., Wilkinson G.W.;
RT "Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular
RT sequestration of the NKG2D ligands MICA and MICB.";
RL J. Virol. 82:4585-4594(2008).
RN [52] {ECO:0000305}
RP INVOLVEMENT IN MULTIPLE MYELOMA.
RX PubMed=18202175; DOI=10.1073/pnas.0711293105;
RA Jinushi M., Vanneman M., Munshi N.C., Tai Y.-T., Prabhala R.H., Ritz J.,
RA Neuberg D., Anderson K.C., Carrasco D.R., Dranoff G.;
RT "MHC class I chain-related protein A antibodies and shedding are associated
RT with the progression of multiple myeloma.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:1285-1290(2008).
RN [53] {ECO:0000305}
RP X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 24-297, AND DISULFIDE BONDS.
RX PubMed=10367903; DOI=10.1016/s1074-7613(00)80057-6;
RA Li P., Willie S.T., Bauer S., Morris D.L., Spies T., Strong R.K.;
RT "Crystal structure of the MHC class I homolog MIC-A, a gammadelta T cell
RT ligand.";
RL Immunity 10:577-584(1999).
RN [54] {ECO:0000305, ECO:0000312|PDB:1HYR}
RP X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 24-297 IN COMPLEX WITH KLRK1.
RX PubMed=11323699; DOI=10.1038/87757;
RA Li P., Morris D.L., Willcox B.E., Steinle A., Spies T., Strong R.K.;
RT "Complex structure of the activating immunoreceptor NKG2D and its MHC class
RT I-like ligand MICA.";
RL Nat. Immunol. 2:443-451(2001).
CC -!- FUNCTION: Seems to have no role in antigen presentation. Acts as a
CC stress-induced self-antigen that is recognized by gamma delta T-cells.
CC Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell
CC lysis. {ECO:0000269|PubMed:10426993, ECO:0000269|PubMed:11224526,
CC ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:11777960,
CC ECO:0000269|PubMed:9497295}.
CC -!- SUBUNIT: Unlike classical MHC class I molecules, does not form a
CC heterodimer with beta-2-microglobulin. Binds as a monomer to a
CC KLRK1/NKG2D homodimer. KLRK1 forms a complex with HCST/DAP10 in which
CC KLRK1 binds MICA while HCST acts as an adapter molecule which enables
CC signal transduction. Interacts with PDIA6 on the surface of tumor
CC cells, leading to disulfide bond reduction which is required for
CC release of MICA from tumor cells. Interacts with human
CC cytomegalovirus/HHV-5 protein UL142. {ECO:0000269|PubMed:10426993,
CC ECO:0000269|PubMed:10426994, ECO:0000269|PubMed:11323699,
CC ECO:0000269|PubMed:11491531, ECO:0000269|PubMed:17495932,
CC ECO:0000269|PubMed:8901601, ECO:0000269|PubMed:9396860}.
CC -!- SUBUNIT: (Microbial infection) Interacts with human
CC cytomegalovirus/HHV-5 protein UL142. {ECO:0000269|PubMed:19793804}.
CC -!- INTERACTION:
CC Q29983; P26718: KLRK1; NbExp=2; IntAct=EBI-1031130, EBI-458344;
CC Q29983; P17931: LGALS3; NbExp=2; IntAct=EBI-1031130, EBI-1170392;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10363723,
CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}; Single-pass
CC type I membrane protein {ECO:0000269|PubMed:10363723,
CC ECO:0000269|PubMed:18287244, ECO:0000269|PubMed:8901601}. Cytoplasm
CC {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244,
CC ECO:0000269|PubMed:8901601}. Note=Expressed on the cell surface in
CC gastric epithelium, endothelial cells and fibroblasts and in the
CC cytoplasm in keratinocytes and monocytes. Infection with human
CC adenovirus 5 suppresses cell surface expression due to the adenoviral
CC E3-19K protein which causes retention in the endoplasmic reticulum.
CC {ECO:0000269|PubMed:10363723, ECO:0000269|PubMed:18287244,
CC ECO:0000269|PubMed:8901601}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1 {ECO:0000269|PubMed:12466900}; Synonyms=MICA1
CC {ECO:0000269|PubMed:12466900};
CC IsoId=Q29983-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12466900}; Synonyms=MICA2
CC {ECO:0000269|PubMed:12466900};
CC IsoId=Q29983-2; Sequence=VSP_055366;
CC -!- TISSUE SPECIFICITY: Widely expressed with the exception of the central
CC nervous system where it is absent. Expressed predominantly in gastric
CC epithelium and also in monocytes, keratinocytes, endothelial cells,
CC fibroblasts and in the outer layer of Hassal's corpuscles within the
CC medulla of normal thymus. In skin, expressed mainly in the keratin
CC layers, basal cells, ducts and follicles. Also expressed in many, but
CC not all, epithelial tumors of lung, breast, kidney, ovary, prostate and
CC colon. In thyomas, overexpressed in cortical and medullar epithelial
CC cells. Tumors expressing MICA display increased levels of gamma delta
CC T-cells. {ECO:0000269|PubMed:10359807, ECO:0000269|PubMed:10363723,
CC ECO:0000269|PubMed:10691930, ECO:0000269|PubMed:12902493,
CC ECO:0000269|PubMed:17565371, ECO:0000269|PubMed:8901601,
CC ECO:0000269|PubMed:9396860}.
CC -!- INDUCTION: By heat shock, by infection with human cytomegalovirus
CC (HCMV), human adenovirus 5, M.tuberculosis and diarrheagenic E.coli,
CC and by exposure to DNA damaging conditions such as high doses of
CC ionizing radiation, chromatin-modifying treatments and inhibitors of
CC DNA replication. The HCMV UL142 protein causes down-regulation of the
CC full-length protein but not of the truncated MICA*008 allele.
CC {ECO:0000269|PubMed:11224526, ECO:0000269|PubMed:11485740,
CC ECO:0000269|PubMed:11830641, ECO:0000269|PubMed:15995699,
CC ECO:0000269|PubMed:16750166, ECO:0000269|PubMed:18287244,
CC ECO:0000269|PubMed:8901601, ECO:0000269|PubMed:9497295}.
CC -!- PTM: N-glycosylated. Glycosylation is not essential for interaction
CC with KLRK1/NKG2D but enhances complex formation.
CC {ECO:0000269|PubMed:8901601}.
CC -!- PTM: Proteolytically cleaved and released from the cell surface of
CC tumor cells which impairs KLRK1/NKG2D expression and T-cell activation.
CC {ECO:0000269|PubMed:12370336, ECO:0000269|PubMed:12384702}.
CC -!- POLYMORPHISM: The following alleles of MICA are known: MICA*001,
CC MICA*002, MICA*004, MICA*005, MICA*006, MICA*007, MICA*008, MICA*009,
CC MICA*010, MICA*011, MICA*012, MICA*013, MICA*014, MICA*015, MICA*016,
CC MICA*017, MICA*018, MICA*019, MICA*020, MICA*022, MICA*023, MICA*024,
CC MICA*025, MICA*026, MICA*027, MICA*028, MICA*029, MICA*030, MICA*031,
CC MICA*032, MICA*033, MICA*034, MICA*035, MICA*036, MICA*037, MICA*038,
CC MICA*039, MICA*040, MICA*041, MICA*042, MICA*043, MICA*044, MICA*045,
CC MICA*046, MICA*047, MICA*048, MICA*049, MICA*050, MICA*051, MICA*052,
CC MICA*053, MICA*054, MICA*055 and MICA*056. The sequence shown is that
CC of MICA*001. {ECO:0000305}.
CC -!- DISEASE: Note=Anti-MICA antibodies and ligand shedding are involved in
CC the progression of monoclonal gammopathy of undetermined significance
CC (MGUS)to multiple myeloma.
CC -!- DISEASE: Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic
CC inflammatory disease of the skin with multifactorial etiology. It is
CC characterized by red, scaly plaques usually found on the scalp, elbows
CC and knees. These lesions are caused by abnormal keratinocyte
CC proliferation and infiltration of inflammatory cells into the dermis
CC and epidermis. Note=Disease susceptibility is associated with variants
CC affecting the gene represented in this entry.
CC -!- DISEASE: Psoriatic arthritis (PSORAS) [MIM:607507]: An inflammatory,
CC seronegative arthritis associated with psoriasis. It is a heterogeneous
CC disorder ranging from a mild, non-destructive disease to a severe,
CC progressive, erosive arthropathy. Five types of psoriatic arthritis
CC have been defined: asymmetrical oligoarthritis characterized by primary
CC involvement of the small joints of the fingers or toes; asymmetrical
CC arthritis which involves the joints of the extremities; symmetrical
CC polyarthritis characterized by a rheumatoid like pattern that can
CC involve hands, wrists, ankles, and feet; arthritis mutilans, which is a
CC rare but deforming and destructive condition; arthritis of the
CC sacroiliac joints and spine (psoriatic spondylitis).
CC {ECO:0000269|PubMed:10323458}. Note=Disease susceptibility is
CC associated with variants affecting the gene represented in this entry.
CC -!- MISCELLANEOUS: Recognized by antibodies in the sera of some organ
CC transplant recipients and may be a target molecule in allograft
CC rejection. {ECO:0000269|PubMed:11053635}.
CC -!- MISCELLANEOUS: [Isoform 2]: Found in about 10% of examined clones.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the MHC class I family. MIC subfamily.
CC {ECO:0000255}.
CC ---------------------------------------------------------------------------
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DR EMBL; L14848; AAA21718.1; -; mRNA.
DR EMBL; X92841; CAA63427.1; -; Genomic_DNA.
DR EMBL; AL845443; CAI41907.1; -; Genomic_DNA.
DR EMBL; CR847852; CAQ11015.1; -; Genomic_DNA.
DR EMBL; BC016929; AAH16929.1; -; mRNA.
DR EMBL; BG114064; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; L29406; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L29408; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L29409; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; L29411; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; U56940; AAB41060.1; -; Genomic_DNA.
DR EMBL; U56941; AAB41061.1; -; Genomic_DNA.
DR EMBL; U56942; AAB41062.1; -; Genomic_DNA.
DR EMBL; U56943; AAB41063.1; -; Genomic_DNA.
DR EMBL; U56944; AAB41064.1; -; Genomic_DNA.
DR EMBL; U56945; AAB41065.1; -; Genomic_DNA.
DR EMBL; U56946; AAB41066.1; -; Genomic_DNA.
DR EMBL; U56947; AAB41067.1; -; Genomic_DNA.
DR EMBL; U56948; AAB41068.1; -; Genomic_DNA.
DR EMBL; U56949; AAB41069.1; -; Genomic_DNA.
DR EMBL; U56950; AAB41070.1; -; Genomic_DNA.
DR EMBL; U56951; AAB41071.1; -; Genomic_DNA.
DR EMBL; U56952; AAB41072.1; -; Genomic_DNA.
DR EMBL; U56953; AAB41073.1; -; Genomic_DNA.
DR EMBL; U56954; AAB41074.1; -; Genomic_DNA.
DR EMBL; U56955; AAB41075.1; -; Genomic_DNA.
DR EMBL; Y16801; CAA76393.1; -; Genomic_DNA.
DR EMBL; Y16802; CAA76394.1; -; Genomic_DNA.
DR EMBL; Y16803; CAA76395.1; -; Genomic_DNA.
DR EMBL; Y16804; CAA76396.1; -; Genomic_DNA.
DR EMBL; Y16805; CAA76397.1; -; Genomic_DNA.
DR EMBL; Y16806; CAA76398.1; -; Genomic_DNA.
DR EMBL; Y16807; CAA76399.1; -; Genomic_DNA.
DR EMBL; Y16808; CAA76400.1; -; Genomic_DNA.
DR EMBL; Y16809; CAA76401.1; -; Genomic_DNA.
DR EMBL; Y16810; CAA76402.1; -; Genomic_DNA.
DR EMBL; Y16811; CAA76403.1; -; Genomic_DNA.
DR EMBL; Y18110; CAA77029.1; -; Genomic_DNA.
DR EMBL; Y18111; CAA77030.1; -; Genomic_DNA.
DR EMBL; Y18112; CAA77031.1; -; Genomic_DNA.
DR EMBL; AF097403; AAD27006.1; -; Genomic_DNA.
DR EMBL; AF097404; AAD27007.1; -; Genomic_DNA.
DR EMBL; AF097405; AAD27008.1; -; Genomic_DNA.
DR EMBL; AF097406; AAD27009.1; -; Genomic_DNA.
DR EMBL; AB015600; BAA29034.1; -; Genomic_DNA.
DR EMBL; AJ563426; CAD91415.1; -; Genomic_DNA.
DR EMBL; AH007168; AAD01474.1; -; Genomic_DNA.
DR EMBL; AH007170; AAD01476.1; -; Genomic_DNA.
DR EMBL; AH007171; AAD01477.1; -; Genomic_DNA.
DR EMBL; AH007173; AAD01479.1; -; Genomic_DNA.
DR EMBL; AH007174; AAD01480.1; -; Genomic_DNA.
DR EMBL; AH007186; AAD01492.1; -; Genomic_DNA.
DR EMBL; AH007175; AAD01481.1; -; Genomic_DNA.
DR EMBL; AH007176; AAD01482.1; -; Genomic_DNA.
DR EMBL; AH007177; AAD01483.1; -; Genomic_DNA.
DR EMBL; AH007178; AAD01484.1; -; Genomic_DNA.
DR EMBL; AH007179; AAD01485.1; -; Genomic_DNA.
DR EMBL; AH007180; AAD01486.1; -; Genomic_DNA.
DR EMBL; AH007182; AAD01488.1; -; Genomic_DNA.
DR EMBL; AH007183; AAD01489.1; -; Genomic_DNA.
DR EMBL; AH007184; AAD01490.1; -; Genomic_DNA.
DR EMBL; AH007185; AAD01491.1; -; Genomic_DNA.
DR EMBL; AH008136; AAD52060.1; -; Genomic_DNA.
DR EMBL; AH008137; AAD52061.1; -; Genomic_DNA.
DR EMBL; AH008138; AAD52062.1; -; Genomic_DNA.
DR EMBL; AH008139; AAD52063.1; -; Genomic_DNA.
DR EMBL; AH008140; AAD52064.1; -; Genomic_DNA.
DR EMBL; AH008141; AAD52065.1; -; Genomic_DNA.
DR EMBL; AH008142; AAD52066.1; -; Genomic_DNA.
DR EMBL; AH008143; AAD52067.1; -; Genomic_DNA.
DR EMBL; AH008144; AAD52068.1; -; Genomic_DNA.
DR EMBL; AH008145; AAD52069.1; -; Genomic_DNA.
DR EMBL; AH008146; AAD52070.1; -; Genomic_DNA.
DR EMBL; AH008147; AAD52071.1; -; Genomic_DNA.
DR EMBL; AH008148; AAD52072.1; -; Genomic_DNA.
DR EMBL; AH007169; AAD01475.1; -; Genomic_DNA.
DR EMBL; AH007172; AAD01478.1; -; Genomic_DNA.
DR EMBL; AH007167; AAD01473.1; -; Genomic_DNA.
DR EMBL; AH007181; AAD01487.1; -; Genomic_DNA.
DR EMBL; AH010819; AAK58536.1; -; Genomic_DNA.
DR EMBL; AH011143; AAL13171.1; -; Genomic_DNA.
DR EMBL; AH010820; AAK58537.1; -; Genomic_DNA.
DR EMBL; AH010821; AAK58538.1; -; Genomic_DNA.
DR EMBL; AH010545; AAK19622.1; -; Genomic_DNA.
DR EMBL; AH010526; AAK17997.1; -; Genomic_DNA.
DR EMBL; AH010568; AAK25770.1; -; Genomic_DNA.
DR EMBL; AH010569; AAK25771.1; -; Genomic_DNA.
DR EMBL; AH010532; AAK18281.1; -; Genomic_DNA.
DR EMBL; AH010546; AAK19623.1; -; Genomic_DNA.
DR EMBL; AH010560; AAK20897.1; -; Genomic_DNA.
DR EMBL; AH010561; AAK20898.1; -; Genomic_DNA.
DR EMBL; AH010587; AAK27364.1; -; Genomic_DNA.
DR EMBL; AH010562; AAK20899.1; -; Genomic_DNA.
DR EMBL; AH010571; AAK26323.1; -; Genomic_DNA.
DR EMBL; AH010572; AAK26324.1; -; Genomic_DNA.
DR EMBL; AH010740; AAK51140.1; -; Genomic_DNA.
DR EMBL; AJ250499; CAC14280.1; -; Genomic_DNA.
DR EMBL; AJ250500; CAC14281.1; -; Genomic_DNA.
DR EMBL; AJ250501; CAC14282.1; -; Genomic_DNA.
DR EMBL; AJ250502; CAC14283.1; -; Genomic_DNA.
DR EMBL; AJ250503; CAC14284.1; -; Genomic_DNA.
DR EMBL; AJ250504; CAC14285.1; -; Genomic_DNA.
DR EMBL; AJ250505; CAC14286.1; -; Genomic_DNA.
DR EMBL; AJ250506; CAC14287.1; -; Genomic_DNA.
DR EMBL; AJ250507; CAC14288.1; -; Genomic_DNA.
DR EMBL; AJ250802; CAC15380.1; -; Genomic_DNA.
DR EMBL; AJ250803; CAC15381.1; -; Genomic_DNA.
DR EMBL; AJ250804; CAC15382.1; -; Genomic_DNA.
DR EMBL; AJ250805; CAC15383.1; -; Genomic_DNA.
DR EMBL; AJ250990; CAC16142.1; -; Genomic_DNA.
DR EMBL; AJ250991; CAC16143.1; -; Genomic_DNA.
DR EMBL; AJ271789; CAC27561.1; -; Genomic_DNA.
DR EMBL; AY603357; AAV39504.1; -; Genomic_DNA.
DR EMBL; AJ249394; CAB71317.1; -; Genomic_DNA.
DR EMBL; AJ295250; CAC88121.1; -; Genomic_DNA.
DR EMBL; AJ295251; CAC88121.1; JOINED; Genomic_DNA.
DR EMBL; AJ580805; CAE45581.1; -; Genomic_DNA.
DR EMBL; AJ580806; CAE45582.2; -; Genomic_DNA.
DR EMBL; AH014149; AAU95382.1; -; Genomic_DNA.
DR EMBL; AM899996; CAP12057.1; -; Genomic_DNA.
DR EMBL; EU254723; ABX54884.1; -; Genomic_DNA.
DR EMBL; AM944063; CAQ16171.1; -; Genomic_DNA.
DR EMBL; AH006330; AAC28941.1; -; Genomic_DNA.
DR EMBL; AH006331; AAC28942.1; -; Genomic_DNA.
DR EMBL; AH006332; AAC28943.1; -; Genomic_DNA.
DR EMBL; AH006333; AAC28944.1; -; Genomic_DNA.
DR EMBL; AH006334; AAC28945.1; -; Genomic_DNA.
DR EMBL; AH007472; AAD19598.1; -; Genomic_DNA.
DR EMBL; AH007473; AAD19599.1; -; Genomic_DNA.
DR EMBL; AH007474; AAD19600.1; -; Genomic_DNA.
DR EMBL; AH007475; AAD19601.1; -; Genomic_DNA.
DR EMBL; AH007476; AAD19602.1; -; Genomic_DNA.
DR EMBL; AH007477; AAD19603.1; -; Genomic_DNA.
DR EMBL; AF106652; AAD19604.1; -; Genomic_DNA.
DR EMBL; AF106650; AAD19604.1; JOINED; Genomic_DNA.
DR EMBL; AF106651; AAD19604.1; JOINED; Genomic_DNA.
DR EMBL; AH007479; AAD19605.1; -; Genomic_DNA.
DR EMBL; EU267602; ABX60404.1; -; Genomic_DNA.
DR EMBL; AY095537; AAM34484.1; -; Genomic_DNA.
DR PIR; A55739; A55739.
DR RefSeq; NP_000238.1; NM_000247.2. [Q29983-1]
DR PDB; 1B3J; X-ray; 3.00 A; A=24-297.
DR PDB; 1HYR; X-ray; 2.70 A; C=24-297.
DR PDBsum; 1B3J; -.
DR PDBsum; 1HYR; -.
DR AlphaFoldDB; Q29983; -.
DR SMR; Q29983; -.
DR BioGRID; 319735; 108.
DR CORUM; Q29983; -.
DR DIP; DIP-29681N; -.
DR IntAct; Q29983; 33.
DR MINT; Q29983; -.
DR STRING; 9606.ENSP00000413079; -.
DR GlyConnect; 1510; 2 N-Linked glycans (2 sites).
DR GlyGen; Q29983; 6 sites, 2 N-linked glycans (2 sites).
DR iPTMnet; Q29983; -.
DR PhosphoSitePlus; Q29983; -.
DR SwissPalm; Q29983; -.
DR BioMuta; MICA; -.
DR DMDM; 74740024; -.
DR EPD; Q29983; -.
DR jPOST; Q29983; -.
DR MassIVE; Q29983; -.
DR MaxQB; Q29983; -.
DR PeptideAtlas; Q29983; -.
DR PRIDE; Q29983; -.
DR ProteomicsDB; 61284; -. [Q29983-1]
DR DNASU; 100507436; -.
DR Ensembl; ENST00000400325.5; ENSP00000383179.1; ENSG00000183214.12. [Q29983-1]
DR Ensembl; ENST00000418465.5; ENSP00000402134.1; ENSG00000235233.9.
DR Ensembl; ENST00000547609.2; ENSP00000446963.1; ENSG00000183214.12. [Q29983-1]
DR GeneID; 100507436; -.
DR KEGG; hsa:100507436; -.
DR UCSC; uc011ind.3; human. [Q29983-1]
DR CTD; 100507436; -.
DR DisGeNET; 100507436; -.
DR GeneCards; MICA; -.
DR HGNC; HGNC:7090; MICA.
DR MIM; 177900; phenotype.
DR MIM; 600169; gene.
DR MIM; 607507; phenotype.
DR neXtProt; NX_Q29983; -.
DR PharmGKB; PA30811; -.
DR eggNOG; ENOG502RU00; Eukaryota.
DR InParanoid; Q29983; -.
DR OrthoDB; 1276422at2759; -.
DR PhylomeDB; Q29983; -.
DR PathwayCommons; Q29983; -.
DR Reactome; R-HSA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR SignaLink; Q29983; -.
DR BioGRID-ORCS; 100507436; 4 hits in 1035 CRISPR screens.
DR ChiTaRS; MICA; human.
DR EvolutionaryTrace; Q29983; -.
DR GeneWiki; MHC_class_I_polypeptide-related_sequence_A; -.
DR GenomeRNAi; 100507436; -.
DR Pharos; Q29983; Tbio.
DR PRO; PR:Q29983; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q29983; protein.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IDA:BHF-UCL.
DR GO; GO:0005887; C:integral component of plasma membrane; IDA:BHF-UCL.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0046703; F:natural killer cell lectin-like receptor binding; IDA:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IDA:UniProtKB.
DR GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
DR GO; GO:0051607; P:defense response to virus; IDA:UniProtKB.
DR GO; GO:0046629; P:gamma-delta T cell activation; IDA:UniProtKB.
DR GO; GO:0002418; P:immune response to tumor cell; IDA:UniProtKB.
DR GO; GO:0042267; P:natural killer cell mediated cytotoxicity; IDA:UniProtKB.
DR GO; GO:0032815; P:negative regulation of natural killer cell activation; IDA:CACAO.
DR GO; GO:0045953; P:negative regulation of natural killer cell mediated cytotoxicity; IMP:CACAO.
DR GO; GO:0009408; P:response to heat; IDA:UniProtKB.
DR GO; GO:0001913; P:T cell mediated cytotoxicity; IDA:UniProtKB.
DR DisProt; DP00670; -.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane;
KW Cytolysis; Cytoplasm; Disulfide bond; Glycoprotein; Host-virus interaction;
KW Immunity; Immunoglobulin domain; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..23
FT CHAIN 24..383
FT /note="MHC class I polypeptide-related sequence A"
FT /evidence="ECO:0000255"
FT /id="PRO_0000337146"
FT TOPO_DOM 24..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..383
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 207..296
FT /note="Ig-like C1-type"
FT /evidence="ECO:0000255"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 79
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 220
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 261
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 59..64
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:10367903"
FT DISULFID 119..187
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:10367903"
FT DISULFID 225..282
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
FT ECO:0000269|PubMed:10367903"
FT VAR_SEQ 109..204
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055366"
FT VARIANT 29
FT /note="R -> P (in allele MICA*010, allele MICA*025 and
FT allele MICA*054; abolishes cell surface expression,
FT probably by interfering with protein folding;
FT dbSNP:rs9380254)"
FT /evidence="ECO:0000269|PubMed:10752636"
FT /id="VAR_043625"
FT VARIANT 37
FT /note="W -> G (in allele MICA*002, allele MICA*011, allele
FT MICA*013, allele MICA*014, allele MICA*015, allele
FT MICA*017, allele MICA*020, allele MICA*022, allele
FT MICA*023, allele MICA*030, allele MICA*034, allele
FT MICA*035, allele MICA*036, allele MICA*041, allele
FT MICA*044, allele MICA*046, allele MICA*047, allele
FT MICA*052, allele MICA*053 and allele MICA*055;
FT dbSNP:rs1063630)"
FT /id="VAR_043626"
FT VARIANT 47
FT /note="T -> A (in allele MICA*002, allele MICA*004, allele
FT MICA*005, allele MICA*006, allele MICA*007, allele
FT MICA*008, allele MICA*009, allele MICA*010, allele
FT MICA*011, allele MICA*013, allele MICA*014, allele
FT MICA*015, allele MICA*016, allele MICA*017, allele
FT MICA*019, allele MICA*020, allele MICA*022, allele
FT MICA*023, allele MICA*024, allele MICA*025, allele
FT MICA*026, allele MICA*027, allele MICA*028, allele
FT MICA*029, allele MICA*030, allele MICA*031, allele
FT MICA*032, allele MICA*033, allele MICA*034, allele
FT MICA*035, allele MICA*036, allele MICA*037, allele
FT MICA*038, allele MICA*039, allele MICA*040, allele
FT MICA*041, allele MICA*042, allele MICA*043, allele
FT MICA*044, allele MICA*045, allele MICA*046, allele
FT MICA*047, allele MICA*048, allele MICA*049, allele
FT MICA*051, allele MICA*052, allele MICA*053, allele
FT MICA*054, allele MICA*055 and allele MICA*056;
FT dbSNP:rs1051785)"
FT /id="VAR_043627"
FT VARIANT 49
FT /note="V -> G (in allele MICA*041; dbSNP:rs17200158)"
FT /id="VAR_043628"
FT VARIANT 59
FT /note="C -> Y (in allele MICA*004, allele MICA*005, allele
FT MICA*006, allele MICA*008, allele MICA*009, allele
FT MICA*010, allele MICA*016, allele MICA*019, allele
FT MICA*024, allele MICA*025, allele MICA*027, allele
FT MICA*028, allele MICA*031, allele MICA*032, allele
FT MICA*033, allele MICA*042, allele MICA*044, allele
FT MICA*048, allele MICA*049, allele MICA*051, allele MICA*054
FT and allele MICA*056; dbSNP:rs1051786)"
FT /id="VAR_043629"
FT VARIANT 114
FT /note="Q -> R (in allele MICA*017; dbSNP:rs41558312)"
FT /id="VAR_043630"
FT VARIANT 128
FT /note="R -> K (in allele MICA*036; dbSNP:rs41557113)"
FT /id="VAR_043631"
FT VARIANT 137
FT /note="G -> R (in allele MICA*014 and allele MICA*015;
FT dbSNP:rs41556715)"
FT /id="VAR_043632"
FT VARIANT 145
FT /note="L -> V (in allele MICA*004, allele MICA*006, allele
FT MICA*009, allele MICA*044 and allele MICA*049;
FT dbSNP:rs1051790)"
FT /id="VAR_043633"
FT VARIANT 147
FT /note="T -> S (in allele MICA*033; dbSNP:rs41539919)"
FT /id="VAR_043634"
FT VARIANT 148
FT /note="K -> E (in allele MICA*002, allele MICA*004, allele
FT MICA*005, allele MICA*006, allele MICA*007, allele
FT MICA*008, allele MICA*009, allele MICA*010, allele
FT MICA*011, allele MICA*012, allele MICA*013, allele
FT MICA*014, allele MICA*015, allele MICA*016, allele
FT MICA*017, allele MICA*018, allele MICA*019, allele
FT MICA*020, allele MICA*022, allele MICA*023, allele
FT MICA*024, allele MICA*025, allele MICA*026, allele
FT MICA*027, allele MICA*028, allele MICA*029, allele
FT MICA*030, allele MICA*032, allele MICA*033, allele
FT MICA*034, allele MICA*035, allele MICA*036, allele
FT MICA*037, allele MICA*038, allele MICA*039, allele
FT MICA*041, allele MICA*042, allele MICA*043, allele
FT MICA*044, allele MICA*045, allele MICA*046, allele
FT MICA*047, allele MICA*048, allele MICA*049, allele
FT MICA*051, allele MICA*052, allele MICA*053, allele
FT MICA*054, allele MICA*055 and allele MICA*056;
FT dbSNP:rs1051791)"
FT /id="VAR_043635"
FT VARIANT 152
FT /note="M -> V (in allele MICA*004, allele MICA*005, allele
FT MICA*006, allele MICA*008, allele MICA*009, allele
FT MICA*010, allele MICA*013, allele MICA*016, allele
FT MICA*019, allele MICA*022, allele MICA*024, allele
FT MICA*027, allele MICA*028, allele MICA*033, allele
FT MICA*044, allele MICA*048, allele MICA*049, allele
FT MICA*053, allele MICA*054 and allele MICA*056; reduces
FT binding affinity for KLRK1; dbSNP:rs1051792)"
FT /id="VAR_043636"
FT VARIANT 165
FT /note="V -> I (in allele MICA*029; dbSNP:rs3819269)"
FT /id="VAR_043637"
FT VARIANT 174
FT /note="M -> V (in allele MICA*011 and allele MICA*034;
FT dbSNP:rs41560824)"
FT /id="VAR_043638"
FT VARIANT 179
FT /note="H -> L (in allele MICA*012, allele MICA*032 and
FT allele MICA*043; dbSNP:rs3819268)"
FT /id="VAR_043639"
FT VARIANT 196
FT /note="K -> E (in allele MICA*004, allele MICA*006, allele
FT MICA*008, allele MICA*009, allele MICA*010, allele
FT MICA*013, allele MICA*014, allele MICA*016, allele
FT MICA*019, allele MICA*022, allele MICA*024, allele
FT MICA*027, allele MICA*028, allele MICA*033, allele
FT MICA*036, allele MICA*044, allele MICA*048, allele
FT MICA*049, allele MICA*053, allele MICA*054 and allele
FT MICA*056; dbSNP:rs1051794)"
FT /id="VAR_043640"
FT VARIANT 198
FT /note="G -> S (in allele MICA*004, allele MICA*006, allele
FT MICA*009, allele MICA*010, allele MICA*016, allele
FT MICA*019, allele MICA*031, allele MICA*033, allele
FT MICA*036, allele MICA*044, allele MICA*049, allele MICA*054
FT and allele MICA*056; dbSNP:rs1131896)"
FT /id="VAR_043641"
FT VARIANT 199
FT /note="V -> I (in allele MICA*006; dbSNP:rs41549718)"
FT /id="VAR_043642"
FT VARIANT 204
FT /note="T -> R (in allele MICA*004, allele MICA*014, allele
FT MICA*032 and allele MICA*044; dbSNP:rs1131897)"
FT /id="VAR_043643"
FT VARIANT 229
FT /note="G -> S (in allele MICA*004, allele MICA*005, allele
FT MICA*006, allele MICA*008, allele MICA*009, allele
FT MICA*010, allele MICA*016, allele MICA*019, allele
FT MICA*022, allele MICA*024, allele MICA*027, allele
FT MICA*033, allele MICA*034, allele MICA*035, allele
FT MICA*037, allele MICA*038, allele MICA*039, allele
FT MICA*042, allele MICA*044, allele MICA*048, allele
FT MICA*049, allele MICA*053, allele MICA*054 and allele
FT MICA*056; dbSNP:rs1131898)"
FT /id="VAR_043644"
FT VARIANT 231
FT /note="Y -> C (in allele MICA*046; dbSNP:rs41546915)"
FT /id="VAR_043645"
FT VARIANT 233
FT /note="W -> R (in allele MICA*004, allele MICA*005, allele
FT MICA*006, allele MICA*008, allele MICA*009, allele
FT MICA*010, allele MICA*016, allele MICA*019, allele
FT MICA*022, allele MICA*024, allele MICA*027, allele
FT MICA*033, allele MICA*034, allele MICA*035, allele
FT MICA*037, allele MICA*038, allele MICA*039, allele
FT MICA*042, allele MICA*044, allele MICA*048, allele
FT MICA*049, allele MICA*053, allele MICA*054 and allele
FT MICA*056; dbSNP:rs1051798)"
FT /id="VAR_043646"
FT VARIANT 236
FT /note="T -> I (in allele MICA*008, allele MICA*010, allele
FT MICA*016, allele MICA*019, allele MICA*022, allele
FT MICA*027, allele MICA*033, allele MICA*035, allele
FT MICA*037, allele MICA*039, allele MICA*042, allele
FT MICA*048, allele MICA*053, allele MICA*054 and allele
FT MICA*056; dbSNP:rs1140700)"
FT /id="VAR_043647"
FT VARIANT 238
FT /note="S -> T (in allele MICA*004, allele MICA*006, allele
FT MICA*008, allele MICA*009, allele MICA*010, allele
FT MICA*016, allele MICA*019, allele MICA*022, allele
FT MICA*024, allele MICA*027, allele MICA*033, allele
FT MICA*034, allele MICA*035, allele MICA*037, allele
FT MICA*038, allele MICA*039, allele MICA*042, allele
FT MICA*044, allele MICA*048, allele MICA*049, allele
FT MICA*053, allele MICA*054 and allele MICA*056;
FT dbSNP:rs1051799)"
FT /id="VAR_043648"
FT VARIANT 244
FT /note="V -> L (in allele MICA*016 and allele MICA*039;
FT dbSNP:rs41540613)"
FT /id="VAR_043649"
FT VARIANT 253
FT /note="W -> S (in allele MICA*056; dbSNP:rs72558175)"
FT /id="VAR_043869"
FT VARIANT 274
FT /note="Q -> R (in allele MICA*005, allele MICA*008, allele
FT MICA*010, allele MICA*013, allele MICA*016, allele
FT MICA*019, allele MICA*022, allele MICA*027, allele
FT MICA*033, allele MICA*035, allele MICA*037, allele
FT MICA*039, allele MICA*042, allele MICA*045, allele
FT MICA*048, allele MICA*053, allele MICA*054 and allele
FT MICA*056; dbSNP:rs1063635)"
FT /id="VAR_043650"
FT VARIANT 279
FT /note="R -> S (in allele MICA*043; dbSNP:rs41557614)"
FT /id="VAR_043651"
FT VARIANT 291
FT /note="S -> G (in allele MICA*054; dbSNP:rs61759927)"
FT /id="VAR_043652"
FT VARIANT 294
FT /note="P -> A (in allele MICA*011, allele MICA*030 and
FT allele MICA*047; dbSNP:rs41553616)"
FT /id="VAR_043653"
FT VARIANT 300..383
FT /note="VLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQ
FT HPVGTSDHRDATQLGFQPLMSDLGSTGSTEGA -> CWCFRVIGRHSMFLLLLLLLLLL
FT LLFLLLLFSTSVVVRRKHQLQRVQSS (in allele MICA*015 and allele
FT MICA*017)"
FT /id="VAR_043654"
FT VARIANT 318..383
FT /note="AAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHRDATQLGFQP
FT LMSDLGSTGSTEGA -> GCCYFCYYYFLCPLL (in allele MICA*008,
FT allele MICA*023, allele MICA*028 and allele MICA*053)"
FT /id="VAR_043655"
FT VARIANT 319
FT /note="A -> AA (in allele MICA*010, allele MICA*016, allele
FT MICA*019, allele MICA*027, allele MICA*033, allele
FT MICA*048, allele MICA*054 and allele MICA*056)"
FT /id="VAR_043656"
FT VARIANT 319
FT /note="A -> AAA (in allele MICA*004, allele MICA*006,
FT allele MICA*009, allele MICA*011, allele MICA*026, allele
FT MICA*047 and allele MICA*049)"
FT /id="VAR_043657"
FT VARIANT 319
FT /note="A -> AAAA (in allele MICA*050)"
FT /id="VAR_043658"
FT VARIANT 319
FT /note="A -> AAAAA (in allele MICA*055)"
FT /id="VAR_043659"
FT VARIANT 319
FT /note="A -> AAAAAA (in allele MICA*002, allele MICA*041,
FT allele MICA*046 and allele MICA*052)"
FT /id="VAR_043660"
FT VARIANT 319
FT /note="A -> AAAAAAA (in allele MICA*020)"
FT /id="VAR_043661"
FT VARIANT 328
FT /note="V -> I (in allele MICA*052; dbSNP:rs72558178)"
FT /id="VAR_043662"
FT VARIANT 329
FT /note="R -> C (in allele MICA*002, allele MICA*011, allele
FT MICA*020, allele MICA*041, allele MICA*043, allele
FT MICA*046, allele MICA*047, allele MICA*050 and allele
FT MICA*052; dbSNP:rs41554412)"
FT /id="VAR_043663"
FT VARIANT 356
FT /note="T -> M (in allele MICA*049; dbSNP:rs41546114)"
FT /id="VAR_043664"
FT VARIANT 373
FT /note="D -> A (in allele MICA*004, allele MICA*006, allele
FT MICA*010, allele MICA*011, allele MICA*016, allele
FT MICA*019, allele MICA*048 and allele MICA*049;
FT dbSNP:rs9266825)"
FT /id="VAR_043665"
FT VARIANT 377
FT /note="T -> A (in allele MICA*011; dbSNP:rs41545814)"
FT /id="VAR_043666"
FT VARIANT 383
FT /note="A -> T (in allele MICA*018; dbSNP:rs1882)"
FT /id="VAR_043667"
FT STRAND 26..37
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 40..51
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 54..59
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 71..75
FT /evidence="ECO:0007829|PDB:1HYR"
FT HELIX 79..81
FT /evidence="ECO:0007829|PDB:1HYR"
FT HELIX 82..101
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 109..121
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 127..135
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 138..144
FT /evidence="ECO:0007829|PDB:1HYR"
FT TURN 145..148
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 149..151
FT /evidence="ECO:0007829|PDB:1HYR"
FT HELIX 156..170
FT /evidence="ECO:0007829|PDB:1HYR"
FT HELIX 177..196
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 208..213
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 217..233
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 236..241
FT /evidence="ECO:0007829|PDB:1HYR"
FT TURN 248..250
FT /evidence="ECO:0007829|PDB:1B3J"
FT STRAND 251..253
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 260..262
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 264..273
FT /evidence="ECO:0007829|PDB:1HYR"
FT HELIX 277..279
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 280..286
FT /evidence="ECO:0007829|PDB:1HYR"
FT STRAND 289..294
FT /evidence="ECO:0007829|PDB:1HYR"
SQ SEQUENCE 383 AA; 42915 MW; 1FE084813DDA13A8 CRC64;
MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD
RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE
IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY
HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR
QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV
LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR
DATQLGFQPL MSDLGSTGST EGA
