MICS1_CAEEL
ID MICS1_CAEEL Reviewed; 269 AA.
AC Q22638;
DT 25-OCT-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Mitochondrial scaffolding protein 1 {ECO:0000303|PubMed:22245785};
GN Name=mics-1 {ECO:0000303|PubMed:22245785, ECO:0000312|WormBase:T21C9.1a};
GN ORFNames=T21C9.1 {ECO:0000312|WormBase:T21C9.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=22245785; DOI=10.1016/j.exger.2011.12.011;
RA Hoffmann M., Honnen S., Mayatepek E., Waetjen W., Koopman W.J.,
RA Bossinger O., Distelmaier F.;
RT "MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C.
RT elegans.";
RL Exp. Gerontol. 47:270-275(2012).
CC -!- FUNCTION: Plays a role in the regulation of lifespan in a partially
CC daf-16-mediated manner, and may be involved in regulating the levels of
CC reactive oxygen species production in response to heat stress.
CC {ECO:0000269|PubMed:22245785}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in young adults results
CC in an increased adult lifespan. At 37 degrees Celsius, levels of
CC reactive oxygen species are reduced compared to wild-type animals.
CC Double knockout with atad-3 RNAi results in an enhanced increase in
CC adult lifespan as compared to the single mutants and wild-type animals.
CC {ECO:0000269|PubMed:22245785}.
CC -!- CAUTION: Has been shown to interact (via PDZ domain) with atad-3 (via
CC C-terminus) (PubMed:22245785). The physiological significance of this
CC interaction is uncertain; the atad-3 C-terminus is expected to be
CC within the mitochondrial matrix. {ECO:0000269|PubMed:22245785,
CC ECO:0000305}.
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DR EMBL; BX284605; CAA97330.2; -; Genomic_DNA.
DR PIR; D89193; D89193.
DR PIR; T25079; T25079.
DR RefSeq; NP_505712.1; NM_073311.1.
DR AlphaFoldDB; Q22638; -.
DR SMR; Q22638; -.
DR STRING; 6239.T21C9.1; -.
DR EPD; Q22638; -.
DR PaxDb; Q22638; -.
DR PeptideAtlas; Q22638; -.
DR EnsemblMetazoa; T21C9.1a.1; T21C9.1a.1; WBGene00011890.
DR GeneID; 179475; -.
DR KEGG; cel:CELE_T21C9.1; -.
DR UCSC; T21C9.1; c. elegans.
DR CTD; 179475; -.
DR WormBase; T21C9.1a; CE23996; WBGene00011890; mics-1.
DR eggNOG; KOG3528; Eukaryota.
DR HOGENOM; CLU_1035257_0_0_1; -.
DR InParanoid; Q22638; -.
DR OMA; WITEALY; -.
DR PhylomeDB; Q22638; -.
DR PRO; PR:Q22638; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00011890; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q22638; baseline and differential.
DR GO; GO:0016323; C:basolateral plasma membrane; IBA:GO_Central.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR GO; GO:0043113; P:receptor clustering; IBA:GO_Central.
DR GO; GO:0097120; P:receptor localization to synapse; IBA:GO_Central.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; SSF50156; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 3: Inferred from homology;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..269
FT /note="Mitochondrial scaffolding protein 1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000441868"
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..121
FT /note="PDZ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
FT REGION 143..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 269 AA; 29730 MW; 9EF067BEAD776F33 CRC64;
MMVSPPQEDT VFNTDSDPVY EQATDDMTFN DTTTDGNGQE SVPLEALTVV EIEKTSKGFG
FNIVGGTDNP HFVGDIGIYV SSVNSESKSY GVVRTGDKIL SFDGIDMTYK THDEAVEVFR
SVKIGHVAKM LIDREYLHLQ EDRTQTPTAS VSITPQVTPQ TRSTQNNTDT PKSMSHSESK
SRLTSHGLSA VIERIRGKVY EEEDAQSVTS YAPSTHSIID DVPRTPRKPL SLLDPRNNSW
LTEALYVSIG LGALTISGYL AYRFIRGRR
