MICU1_CAEBR
ID MICU1_CAEBR Reviewed; 533 AA.
AC A8WQT4;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Calcium uptake protein 1 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=micu-1 {ECO:0000312|WormBase:CBG01795};
GN ORFNames=CBG01795 {ECO:0000312|WormBase:CBG01795};
OS Caenorhabditis briggsae.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6238;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF16;
RX PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA Durbin R.M., Waterston R.H.;
RT "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT genomics.";
RL PLoS Biol. 1:166-192(2003).
CC -!- FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU).
CC {ECO:0000250|UniProtKB:Q9BPX6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:Q9BPX6}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:Q9BPX6}. Note=The topology is subject to debate.
CC {ECO:0000250|UniProtKB:Q9BPX6}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000305}.
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DR EMBL; HE601298; CAP22842.2; -; Genomic_DNA.
DR AlphaFoldDB; A8WQT4; -.
DR SMR; A8WQT4; -.
DR STRING; 6238.CBG01795; -.
DR WormBase; CBG01795; CBP14257; WBGene00024981; Cbr-micu-1.
DR eggNOG; KOG2643; Eukaryota.
DR HOGENOM; CLU_027103_3_0_1; -.
DR InParanoid; A8WQT4; -.
DR OMA; ALGNIRQ; -.
DR OrthoDB; 707988at2759; -.
DR Proteomes; UP000008549; Chromosome IV.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294; PTHR12294; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 2.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 3: Inferred from homology;
KW Calcium; Calcium transport; Ion transport; Membrane; Metal-binding;
KW Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat;
KW Transit peptide; Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 14..533
FT /note="Calcium uptake protein 1 homolog, mitochondrial"
FT /id="PRO_0000399810"
FT TRANSMEM 95..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 112..533
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT DOMAIN 270..305
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 337..358
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 465..500
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 127..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 133..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 283
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 285
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 287
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 294
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
SQ SEQUENCE 533 AA; 62004 MW; 0DA654C6CAA10615 CRC64;
MLRHNFRSSI FIRIVANSWS ITRSVSSAPI KAESRKQQDS LKNIDSGEAY TALGNIRQKK
DVFHYTDRAS GTGYSHYSNS VYQHRPYIWP PLRKMYNWNY AFVIAGMVIL MSDFEWIKEQ
IKGASTPFRP EASQKEESTD SGTEIEVKEK PKKKKLGFRE RRIIEYEDRL RLYSTPDKIF
RYFATLKIID PNDESGRIFE VFMTPEDFLR SFTPGVMQPR RWGLDSFKAY NPEKHKRHKF
SDPNSIFYKL GENGLINFSD YLFLMTLLST SHADFALAFK IFDVDGNGAL DKEEFTKVQQ
LIMSQTTVGQ RHRDHVTPNS SFRVETNSAL ETYFFGKDGK GSLSSEKFIE FQERLQHDIL
KMEFERRDAM ENSDGLITEE SFAQLLLLHA QIAEKKQKHM LKRVKRRFKG DQSKGVSFDE
TKAFFEFLYH IDDVDIALHF HKMAGMSIDA KLLKRVAVKV TGIPLSDHVV DVVITLFDDN
LDGKLSHEEM VAVMRRRMRR GLERPRDTGL FRLFDAVLEC GKRAYHASPL PFY
