MICU1_CAEEL
ID MICU1_CAEEL Reviewed; 534 AA.
AC Q95PZ2; H1UBL1; H1UBL2; Q8I0Y9;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Calcium uptake protein 1 homolog, mitochondrial;
DE Flags: Precursor;
GN Name=micu-1 {ECO:0000312|WormBase:Y67H2A.4d};
GN ORFNames=Y67H2A.4 {ECO:0000312|WormBase:Y67H2A.4d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=31983639; DOI=10.1016/j.cub.2019.12.061;
RA Tang N.H., Kim K.W., Xu S., Blazie S.M., Yee B.A., Yeo G.W., Jin Y.,
RA Chisholm A.D.;
RT "The mRNA Decay Factor CAR-1/LSM14 Regulates Axon Regeneration via
RT Mitochondrial Calcium Dynamics.";
RL Curr. Biol. 30:865-876(2020).
CC -!- FUNCTION: Key regulator of mitochondrial calcium uniporter (MCU).
CC Modulates the activity of the mitochondrial calcium uniporter protein
CC mcu-1 depending on the level of intracellular calcium in PLM touch
CC receptor neurons following axonal injury (PubMed:31983639).
CC {ECO:0000250|UniProtKB:Q9BPX6, ECO:0000269|PubMed:31983639}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000269|PubMed:31983639}; Single-pass membrane protein
CC {ECO:0000255}. Mitochondrion intermembrane space
CC {ECO:0000250|UniProtKB:Q9BPX6}. Note=The topology is subject to debate.
CC {ECO:0000250|UniProtKB:Q9BPX6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=d {ECO:0000312|WormBase:Y67H2A.4d};
CC IsoId=Q95PZ2-1; Sequence=Displayed;
CC Name=c {ECO:0000312|WormBase:Y67H2A.4c};
CC IsoId=Q95PZ2-3; Sequence=VSP_039909, VSP_039910;
CC -!- TISSUE SPECIFICITY: Expressed at low levels in PLM touch receptor
CC neurons, germ cells, epidermis, and muscles.
CC {ECO:0000269|PubMed:31983639}.
CC -!- SIMILARITY: Belongs to the MICU1 family. MICU1 subfamily.
CC {ECO:0000305}.
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DR EMBL; BX284604; CCF23405.1; -; Genomic_DNA.
DR EMBL; BX284604; CCF23406.1; -; Genomic_DNA.
DR RefSeq; NP_001255723.1; NM_001268794.1. [Q95PZ2-1]
DR RefSeq; NP_001255724.1; NM_001268795.1.
DR AlphaFoldDB; Q95PZ2; -.
DR SMR; Q95PZ2; -.
DR STRING; 6239.Y67H2A.4a; -.
DR EPD; Q95PZ2; -.
DR PaxDb; Q95PZ2; -.
DR EnsemblMetazoa; Y67H2A.4c.1; Y67H2A.4c.1; WBGene00013462. [Q95PZ2-3]
DR EnsemblMetazoa; Y67H2A.4c.2; Y67H2A.4c.2; WBGene00013462. [Q95PZ2-3]
DR EnsemblMetazoa; Y67H2A.4d.1; Y67H2A.4d.1; WBGene00013462. [Q95PZ2-1]
DR GeneID; 178287; -.
DR KEGG; cel:CELE_Y67H2A.4; -.
DR UCSC; Y67H2A.4b; c. elegans.
DR CTD; 178287; -.
DR WormBase; Y67H2A.4c; CE47026; WBGene00013462; micu-1. [Q95PZ2-3]
DR WormBase; Y67H2A.4d; CE47067; WBGene00013462; micu-1. [Q95PZ2-1]
DR eggNOG; KOG2643; Eukaryota.
DR GeneTree; ENSGT00950000183079; -.
DR HOGENOM; CLU_027103_3_0_1; -.
DR InParanoid; Q95PZ2; -.
DR OMA; ALGNIRQ; -.
DR OrthoDB; 707988at2759; -.
DR PhylomeDB; Q95PZ2; -.
DR Reactome; R-CEL-8949215; Mitochondrial calcium ion transport.
DR Reactome; R-CEL-8949664; Processing of SMDT1.
DR PRO; PR:Q95PZ2; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00013462; Expressed in adult organism and 3 other tissues.
DR GO; GO:0005758; C:mitochondrial intermembrane space; IEA:UniProtKB-SubCell.
DR GO; GO:1990246; C:uniplex complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR GO; GO:0036444; P:calcium import into the mitochondrion; IBA:GO_Central.
DR GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IBA:GO_Central.
DR GO; GO:0051561; P:positive regulation of mitochondrial calcium ion concentration; ISS:UniProtKB.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR039800; MICU1/2/3.
DR PANTHER; PTHR12294; PTHR12294; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Calcium transport; Ion transport; Membrane;
KW Metal-binding; Mitochondrion; Mitochondrion inner membrane;
KW Reference proteome; Repeat; Transit peptide; Transmembrane;
KW Transmembrane helix; Transport.
FT TRANSIT 1..32
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 33..534
FT /note="Calcium uptake protein 1 homolog, mitochondrial"
FT /id="PRO_0000399811"
FT TRANSMEM 96..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..534
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT DOMAIN 271..306
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 338..359
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 466..501
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 131..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..150
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 284
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 286
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 288
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 295
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 138..142
FT /note="EVTES -> VSCSC (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_039909"
FT VAR_SEQ 143..534
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000305"
FT /id="VSP_039910"
SQ SEQUENCE 534 AA; 62120 MW; 719510035664EC4B CRC64;
MLHCSFLRVI PIKNASKRLI IVRSLTSAPA KTSEAEKQQD SLKNIDAGEK YTALGNIRQK
KDVFHYTDRA SGVGYSHYSS SVYQHRPYIW PPLRKLYHWN YALVIAGMVI LMSDFEWLKD
QIKSASLPFR PEASQKEEVT ESNGEVEEVK EKPKKKKLGF RERRIIEYED RLRLYSTPDK
IFRYFATLKI IDPNEDSGRF EVFMTPEDFL RSFTPGVMQP RRWGLDSFKN YNPEKHKRHK
FSDPDSIFYK LGENGLINFS DYLFLMTLLS TSHADFALAF KIFDVDGNGA LDKEEFTKVQ
QLIMSQTTVG QRHRDHITPN QSFRVETNSA LETYFFGKDG KGSLSSEKFI EFQERLQHDI
LKMEFERRDA LDNPDGLINE DSFAQLLLLH AQINEKKQKH MLKRVKRRFK GENLKGISFG
ETKAFFEFLY HIDDVDIALH FHKMAGMSID AKLLQRVAVK VTGIPLSDHV VDVVITLFDD
NLDGKLSHEE MVAVMRRRMR RGLERPRDTG LFRLFDAVLE CGKRAYHASP LPFY
