6PGL4_ARATH
ID 6PGL4_ARATH Reviewed; 261 AA.
AC Q9FIN1;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable 6-phosphogluconolactonase 4 {ECO:0000305};
DE Short=6PGL4 {ECO:0000305};
DE EC=3.1.1.31 {ECO:0000250|UniProtKB:Q84WW2};
GN Name=PGL4 {ECO:0000303|PubMed:19457984};
GN OrderedLocusNames=At5g24410 {ECO:0000312|Araport:AT5G24410};
GN ORFNames=K16H17.12 {ECO:0000312|EMBL:BAB11234.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10048488; DOI=10.1093/dnares/5.6.379;
RA Asamizu E., Sato S., Kaneko T., Nakamura Y., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VIII. Sequence
RT features of the regions of 1,081,958 bp covered by seventeen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:379-391(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=19457984; DOI=10.1093/pcp/pcp070;
RA Xiong Y., DeFraia C., Williams D., Zhang X., Mou Z.;
RT "Characterization of Arabidopsis 6-phosphogluconolactonase T-DNA insertion
RT mutants reveals an essential role for the oxidative section of the
RT plastidic pentose phosphate pathway in plant growth and development.";
RL Plant Cell Physiol. 50:1277-1291(2009).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=24008768; DOI=10.1093/mp/sst126;
RA Hoelscher C., Meyer T., von Schaewen A.;
RT "Dual-targeting of Arabidopsis 6-phosphogluconolactonase 3 (PGL3) to
RT chloroplasts and peroxisomes involves interaction with Trx m2 in the
RT cytosol.";
RL Mol. Plant 7:252-255(2014).
CC -!- FUNCTION: Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-
CC phosphogluconate. {ECO:0000250|UniProtKB:Q84WW2}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC Evidence={ECO:0000250|UniProtKB:Q84WW2};
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC 2/3. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24008768}.
CC -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR EMBL; AB016884; BAB11234.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93308.1; -; Genomic_DNA.
DR EMBL; BT010945; AAR24723.1; -; mRNA.
DR EMBL; BT012199; AAS76686.1; -; mRNA.
DR RefSeq; NP_197829.1; NM_122349.4.
DR AlphaFoldDB; Q9FIN1; -.
DR SMR; Q9FIN1; -.
DR STRING; 3702.AT5G24410.1; -.
DR iPTMnet; Q9FIN1; -.
DR PaxDb; Q9FIN1; -.
DR PRIDE; Q9FIN1; -.
DR ProteomicsDB; 245148; -.
DR EnsemblPlants; AT5G24410.1; AT5G24410.1; AT5G24410.
DR GeneID; 832512; -.
DR Gramene; AT5G24410.1; AT5G24410.1; AT5G24410.
DR KEGG; ath:AT5G24410; -.
DR Araport; AT5G24410; -.
DR TAIR; locus:2152911; AT5G24410.
DR eggNOG; KOG3147; Eukaryota.
DR HOGENOM; CLU_053947_0_0_1; -.
DR InParanoid; Q9FIN1; -.
DR OMA; MAVCDEA; -.
DR OrthoDB; 1420529at2759; -.
DR PhylomeDB; Q9FIN1; -.
DR BioCyc; ARA:AT5G24410-MON; -.
DR BRENDA; 3.1.1.31; 399.
DR UniPathway; UPA00115; UER00409.
DR PRO; PR:Q9FIN1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FIN1; baseline and differential.
DR Genevisible; Q9FIN1; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0031982; C:vesicle; IDA:TAIR.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR CDD; cd01400; 6PGL; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR InterPro; IPR039104; PGLS.
DR PANTHER; PTHR11054; PTHR11054; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR SUPFAM; SSF100950; SSF100950; 1.
DR TIGRFAMs; TIGR01198; pgl; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Hydrolase; Reference proteome.
FT CHAIN 1..261
FT /note="Probable 6-phosphogluconolactonase 4"
FT /id="PRO_0000288671"
SQ SEQUENCE 261 AA; 29244 MW; 69C2570CF46D73F4 CRC64;
MASVLEKTKS KKIVFPTKKE LSEAMATYTA NLSAKFCKER GYFTVVLSGG DLISWLSELL
EPKYQESIEW SKWHIFWVDE RVVPLDHEDS NYKLAFDGFL SKVPIPIANI YPIDKDCAAL
GDAKSAALLY EECLKRLVNR NIIRTYKSSG FPQFDLQLLG MGPDGHMASL FPGHYQIKEK
ANLVTYITDS PKPPPKRITF TLPVINCASY NLMAVCDEAQ ADAVAKVFNH NFDLPAAWLT
ADVEAIWFLD QAAASKIPKG L
