MID49_XENLA
ID MID49_XENLA Reviewed; 463 AA.
AC Q6GQ81;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Mitochondrial dynamics protein MID49;
DE AltName: Full=Mitochondrial dynamics protein of 49 kDa homolog;
DE AltName: Full=Mitochondrial elongation factor 2;
DE AltName: Full=Smith-Magenis syndrome chromosomal region candidate gene 7 protein homolog;
GN Name=mief2; Synonyms=mid49, smcr7;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Mitochondrial outer membrane protein which regulates
CC mitochondrial organization (By similarity). It is required for
CC mitochondrial fission and promotes the recruitment and association of
CC the fission mediator dynamin-related protein 1 (DNM1L) to the
CC mitochondrial surface independently of the mitochondrial fission FIS1
CC and MFF proteins (By similarity). Regulates DNM1L GTPase activity (By
CC similarity). {ECO:0000250|UniProtKB:Q96C03}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- MISCELLANEOUS: Does not bind ADP or other nucleotides, in contrast to
CC MIEF1. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MID49/MID51 family. {ECO:0000305}.
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DR EMBL; BC072866; AAH72866.1; -; mRNA.
DR RefSeq; NP_001085509.1; NM_001092040.1.
DR AlphaFoldDB; Q6GQ81; -.
DR SMR; Q6GQ81; -.
DR DNASU; 443935; -.
DR GeneID; 443935; -.
DR KEGG; xla:443935; -.
DR CTD; 443935; -.
DR Xenbase; XB-GENE-977726; mief2.S.
DR OrthoDB; 515815at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 443935; Expressed in ovary and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR GO; GO:0003374; P:dynamin family protein polymerization involved in mitochondrial fission; ISS:UniProtKB.
DR GO; GO:0007005; P:mitochondrion organization; ISS:UniProtKB.
DR GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
DR GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
DR InterPro; IPR024810; Mab-21_dom.
DR InterPro; IPR045909; MID49/MID51.
DR PANTHER; PTHR16451; PTHR16451; 1.
DR Pfam; PF03281; Mab-21; 1.
DR SMART; SM01265; Mab-21; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..463
FT /note="Mitochondrial dynamics protein MID49"
FT /id="PRO_0000310454"
FT TOPO_DOM 1..24
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000255"
FT TRANSMEM 25..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..463
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 87..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 51991 MW; 4D7C50BE4D17D6AF CRC64;
MAELQIRKKE KKSGDGIGTM VDFLLANARL VLGVGGAAML GIATLAVKRL IDRATSPPSD
KEAEEKAEQK SIEESWKEAV LKKASPTLRR KEDLEHHCAP LSLPDPSQKM PEATGTSQVK
ASDEIKKIPI CFTLQERLLN YHTHHASVPE VQMEEARQLV LDIKKELQEF LHAKHPEMPF
LALHLGGSFG NRLPMSCLDH ACLIMPLVLE PDLWCVIPGQ KTILSDPNFC MVKRIDLEYT
SRGSSPWDRF LVGAYLSSRT MVQSLHKTIV GSINWPAIGT VLDCTIKPDI TSDELKLEVV
HPNGHMIIRI LPMAVIKDAD LLAHCCATAP AENLWQRSFY KKEVSRLQEL DSSDSGIRLK
CLQILKGICR DCPSLCHLNS THLRHILLHL STESSDWTET ALADRFLQVL EELIGYLDKG
FLPSYFNDKL NLFSSLKAED IEELGYGLYQ VFSEPDDVLK RER