ID   MIDNA_XENLA             Reviewed;         453 AA.
AC   Q7ZWN4;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Midnolin-A;
DE   AltName: Full=Midbrain nucleolar protein A;
GN   Name=midn-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Facilitates ubiquitin-independent proteasomal degradation of
CC       polycomb protein CBX4. Plays a role in inhibiting the activity of
CC       glucokinase GCK and both glucose-induced and basal insulin secretion.
CC       {ECO:0000250|UniProtKB:D4AE48, ECO:0000250|UniProtKB:Q3TPJ7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TPJ7}.
CC       Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3TPJ7}. Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q3TPJ7}. Note=Detected in the nucleus and
CC       nucleolus with no expression in the cytoplasm. However, a later study
CC       finds expression in the nucleus and cytoplasm with no expression in the
CC       nucleolus. {ECO:0000250|UniProtKB:Q3TPJ7}.
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DR   EMBL; BC046865; AAH46865.1; -; mRNA.
DR   RefSeq; NP_001079678.1; NM_001086209.1.
DR   AlphaFoldDB; Q7ZWN4; -.
DR   SMR; Q7ZWN4; -.
DR   DNASU; 379365; -.
DR   GeneID; 379365; -.
DR   KEGG; xla:379365; -.
DR   CTD; 379365; -.
DR   Xenbase; XB-GENE-1005239; midn.L.
DR   OMA; EANCSTN; -.
DR   OrthoDB; 1159802at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379365; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039336; Midnolin.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23010; PTHR23010; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome.
FT   CHAIN           1..453
FT                   /note="Midnolin-A"
FT                   /id="PRO_0000287539"
FT   DOMAIN          20..94
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   REGION          184..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..256
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..429
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        236..256
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..365
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        410..429
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   453 AA;  49543 MW;  899816BABC82FD24 CRC64;
     MEQQPSVPRS CTNVARETPM NLNIQSTTGT RYELSVPPDE TVDGLKRRIS QRLKVPKDRL
     TLLHRETRLS SGKLQDLGIS DGSRLTLLPS VEAGLMSQMS RPEQSVMQAL ESLTETQVND
     FLSGRSPLTL ALRVGDHMMF VQLQLAAQQS GSSHLQHRHV ITRGAETSAS PQYRTLHTST
     SAVSHLASCT PGPTPPTTLS PTSSTHCNGP HSSPLTTSVF RSHGEGVAVS PCAEQAPCST
     RGTEGTSSSP SSRSRKPGAI IESFVNHAPG VFSGTFSGTL HPQCQDSAGR PRRDIGTILQ
     ILNDLLSATR HYQGMPPSLT TLRCHTQCAS QARNAKATSP QSTSPQQTTH PVGHCQTQTR
     TYKPSGDRLR QTENRATRCK VERLQLLMHQ KRLRRKARRD SRAPYHWMPT RKSSRTSSNS
     STSSGEGSLE IDFEDSLWKP DVKAELNSEF VVA