ID   MIER2_BOVIN             Reviewed;         561 AA.
AC   A5PJX4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Mesoderm induction early response protein 2;
DE            Short=Mi-er2;
GN   Name=MIER2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex containing at least CDYL, MIER1, MIER2,
CC       HDAC1 and HDAC2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC       ECO:0000255|PROSITE-ProRule:PRU00624}.
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DR   EMBL; BC142273; AAI42274.1; -; mRNA.
DR   RefSeq; NP_001092496.1; NM_001099026.2.
DR   AlphaFoldDB; A5PJX4; -.
DR   STRING; 9913.ENSBTAP00000026341; -.
DR   PaxDb; A5PJX4; -.
DR   PRIDE; A5PJX4; -.
DR   GeneID; 523726; -.
DR   KEGG; bta:523726; -.
DR   CTD; 54531; -.
DR   eggNOG; KOG4329; Eukaryota.
DR   InParanoid; A5PJX4; -.
DR   OrthoDB; 1062529at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0042826; F:histone deacetylase binding; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR040138; MIER/MTA.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   PANTHER; PTHR10865; PTHR10865; 1.
DR   Pfam; PF01448; ELM2; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..561
FT                   /note="Mesoderm induction early response protein 2"
FT                   /id="PRO_0000313677"
FT   DOMAIN          195..292
FT                   /note="ELM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT   DOMAIN          297..349
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          52..188
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          360..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        61..79
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..135
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        143..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        385..399
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         11
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8N344"
SQ   SEQUENCE   561 AA;  61299 MW;  3F77270DB73DA4B3 CRC64;
     MAEASSLERQ SPGAASCLPH SLCPGEPNLQ TTAVVSMGSA DHQFHLAEIL SQNYGVREEH
     EGAAPGPEKP EEELEKDFVS QSSDMPLDEL LALYGYETSD PISERESEGS DTAAHLPDMT
     LDKDQIAKDL LSGEEEEETQ SSADDLTPSV TSHEASDLFP SQSGSCFLAD ADKEPGSSSS
     SDAEEDPLPA NKCKKEIMVG PQFQADLSNL HSNRHGEKIY ENEDQLLWDP NILPEREVEE
     FLYRAVKRRW HEMAGSQLPE GEAVKDSEQA LYELVKCNFN AEEALRRLRF NVKVIRDGLC
     AWSEEERRNF EHGFRVHGKN FHLIQANKVR TRSVGECVEY YYLWKKSERY DYFSQQTRLG
     RRKYGPSGNT DADQDLEGSD PDGPGRPRSS PPLPLPAAAH GPGPEHDRLA QMHTEPLSMG
     SSMSRSLGEP GEALDVPPSS EPGPRLFPPL DEPSALPSSR RPPALAEPAF FPPATAAPEP
     GASPRLAVDL TLPEELPLVS SHEDTDGEPE ETVGPPQVAL SVAEFGLIGI GDVNPFLASH
     PACPASGLHS EPLSHCNVMT C