ID   MIER3_MACFA             Reviewed;         550 AA.
AC   Q4R3R9; Q4R718;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Mesoderm induction early response protein 3;
DE            Short=Mi-er3;
GN   Name=MIER3; ORFNames=QtsA-14674, QtsA-16550;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC       ECO:0000255|PROSITE-ProRule:PRU00624}.
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DR   EMBL; AB169011; BAE01106.1; -; mRNA.
DR   EMBL; AB179196; BAE02247.1; -; mRNA.
DR   RefSeq; XP_005556987.1; XM_005556930.2.
DR   AlphaFoldDB; Q4R3R9; -.
DR   STRING; 9541.XP_005556984.1; -.
DR   GeneID; 101925174; -.
DR   KEGG; mcf:101925174; -.
DR   CTD; 166968; -.
DR   VEuPathDB; HostDB:ENSMFAG00000042794; -.
DR   eggNOG; KOG4329; Eukaryota.
DR   OMA; NQMNMCS; -.
DR   Proteomes; UP000233100; Chromosome 6.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR040138; MIER/MTA.
DR   InterPro; IPR045787; MIER1/3_C.
DR   InterPro; IPR031156; MIER3.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   PANTHER; PTHR10865; PTHR10865; 1.
DR   PANTHER; PTHR10865:SF22; PTHR10865:SF22; 1.
DR   Pfam; PF01448; ELM2; 1.
DR   Pfam; PF19426; MIER1_beta_C; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..550
FT                   /note="Mesoderm induction early response protein 3"
FT                   /id="PRO_0000313681"
FT   DOMAIN          174..272
FT                   /note="ELM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT   DOMAIN          277..329
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   REGION          1..60
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          113..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..35
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..144
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         52
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT   MOD_RES         53
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT   MOD_RES         114
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT   MOD_RES         156
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3K6"
FT   MOD_RES         163
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT   MOD_RES         165
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT   MOD_RES         168
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q3UHF3"
FT   CONFLICT        412
FT                   /note="D -> V (in Ref. 1; BAE01106)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   550 AA;  61396 MW;  EEDBD6E86BFEDEA3 CRC64;
     MAEASFGSSS PVGSLSSEDH DFDPTAEMLV HDYDDERTLE EEEMMDEGKN FSSEIEDLEK
     EGTMPLEDLL AFYGYEPTIP AVANSSANSS PSELADELPD MTLDKEEIAK DLLSGDDEET
     QSSADDLTPS VTSHETSDFF PRPLRSNTTC DGDKESEVED VETDSGNSPE DLRKEIMIGL
     QYQAEIPPYL GEYAGNEKVY ENEDQLLWCP DVVLESKVKE YLVETSLRTG NEKIMDRISA
     GTHTRDNEQA LYELLKCNHN IKEAIERYCC NGKASQEGMT AWTEEECRSF EHALMLFGKD
     FHLIQKNKVR TRTVAECVAF YYMWKKSERY DYFAQQTRFG KKRYNHHPGV TDYMDRLVDE
     TEALGGTVNA SALTSNRPEP IPDQQLNILN SFTASDLTAL TNSVATVCDP TDVNCLDDSF
     PPLGSTPRGQ VNHVPVVTEE LLTLPSNGES DCFNLFETGF YHSELNPMNM CSEESERPAK
     RLKMGIAVPE SFMNEVSVNN LGVDFENHTH HITSAKMAVS VADFGSLSAS ETNGFISAHA
     LHQHAALHSE