ID   MIF1_ARATH              Reviewed;         102 AA.
AC   Q9CA51; Q8LEN6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Mini zinc finger protein 1;
DE            Short=AtMIF1;
GN   Name=MIF1; OrderedLocusNames=At1g74660; ORFNames=F1M20.34;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Kim C.J., Chen H., Shinn P., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA   Feldmann K.A.;
RT   "Full-length cDNA from Arabidopsis thaliana.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=16412086; DOI=10.1111/j.1365-313x.2005.02626.x;
RA   Hu W., Ma H.;
RT   "Characterization of a novel putative zinc finger gene MIF1: involvement in
RT   multiple hormonal regulation of Arabidopsis development.";
RL   Plant J. 45:399-422(2006).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA   Hu W., dePamphilis C.W., Ma H.;
RT   "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT   zinc finger gene families.";
RL   J. Integr. Plant Biol. 50:1031-1045(2008).
RN   [7]
RP   FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH ZHD1; ZHD5; ZHD6;
RP   ZHD7; ZHD8; ZHD10 AND ZHD13, GENE FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA   Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT   "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT   modulated by a competitive peptide inhibitor in Arabidopsis.";
RL   J. Biol. Chem. 286:1659-1668(2011).
RN   [8]
RP   FUNCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=21455630; DOI=10.1007/s11103-011-9768-y;
RA   Hu W., Feng B., Ma H.;
RT   "Ectopic expression of the Arabidopsis MINI ZINC FINGER1 and MIF3 genes
RT   induces shoot meristems on leaf margins.";
RL   Plant Mol. Biol. 76:57-68(2011).
CC   -!- FUNCTION: Inhibits zinc finger homeodomain (ZHD) transcription factors,
CC       such as ZHD5, by interacting with them to prevent both their nuclear
CC       localization and their DNA-binding properties. Involved in integrating
CC       signals from multiple hormones by preventing the expression of genes
CC       involved in gibberellic acid (GA), auxin and brassinosteroid signaling
CC       and by promoting the expression of abscisic acid (ABA)-responsive
CC       genes. Regulates several development aspects, including
CC       photomorphogenesis, apical dominance, longevity, flower morphology and
CC       fertility, as well as root and stem elongation. Promotes the formation
CC       of ectopic shoot meristems on leaf margins.
CC       {ECO:0000269|PubMed:16412086, ECO:0000269|PubMed:21059647,
CC       ECO:0000269|PubMed:21455630}.
CC   -!- SUBUNIT: Homo- and heterodimers. Interacts with ZHD1, ZHD5, ZHD6, ZHD7,
CC       ZHD8, ZHD10 and ZHD13. {ECO:0000269|PubMed:21059647}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21059647}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in roots and stems, present in
CC       siliques and seedlings, and weakly observed in petioles, leaves and
CC       flowers. {ECO:0000269|PubMed:16412086}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM62558.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AC011765; AAG52375.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE35619.1; -; Genomic_DNA.
DR   EMBL; BT024806; ABD60689.1; -; mRNA.
DR   EMBL; AY085327; AAM62558.1; ALT_INIT; mRNA.
DR   PIR; G96775; G96775.
DR   RefSeq; NP_565088.1; NM_106124.2.
DR   AlphaFoldDB; Q9CA51; -.
DR   BioGRID; 29024; 2.
DR   IntAct; Q9CA51; 2.
DR   STRING; 3702.AT1G74660.1; -.
DR   PaxDb; Q9CA51; -.
DR   PRIDE; Q9CA51; -.
DR   ProteomicsDB; 238706; -.
DR   EnsemblPlants; AT1G74660.1; AT1G74660.1; AT1G74660.
DR   GeneID; 843805; -.
DR   Gramene; AT1G74660.1; AT1G74660.1; AT1G74660.
DR   KEGG; ath:AT1G74660; -.
DR   Araport; AT1G74660; -.
DR   TAIR; locus:2019190; AT1G74660.
DR   eggNOG; ENOG502S2AW; Eukaryota.
DR   HOGENOM; CLU_123565_0_0_1; -.
DR   InParanoid; Q9CA51; -.
DR   OMA; DEALTCA; -.
DR   OrthoDB; 1558346at2759; -.
DR   PhylomeDB; Q9CA51; -.
DR   PRO; PR:Q9CA51; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9CA51; baseline and differential.
DR   Genevisible; Q9CA51; AT.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; IDA:TAIR.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR   GO; GO:0043392; P:negative regulation of DNA binding; IDA:TAIR.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:TAIR.
DR   GO; GO:0009640; P:photomorphogenesis; IMP:TAIR.
DR   GO; GO:0048509; P:regulation of meristem development; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR   GO; GO:0009733; P:response to auxin; IMP:TAIR.
DR   GO; GO:0009741; P:response to brassinosteroid; IMP:TAIR.
DR   GO; GO:0009735; P:response to cytokinin; IMP:TAIR.
DR   GO; GO:0009739; P:response to gibberellin; IMP:TAIR.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..102
FT                   /note="Mini zinc finger protein 1"
FT                   /id="PRO_0000426014"
FT   ZN_FING         39..88
FT                   /note="ZF-HD dimerization-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   102 AA;  11213 MW;  E7A701A002041020 CRC64;
     MMKKRQMVIK QRSRNSNTSS SWTTTSSSSS SSEISNVRYV ECQKNHAANI GGYAVDGCRE
     FMAAGVEGTV DALRCAACGC HRNFHRKEVD TEVVCEYSPP NA