MIF2_ARATH
ID MIF2_ARATH Reviewed; 100 AA.
AC Q9LJW5;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Mini zinc finger protein 2;
DE Short=AtMIF2;
GN Name=MIF2; OrderedLocusNames=At3g28917; ORFNames=MLD15.10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10907853; DOI=10.1093/dnares/7.3.217;
RA Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. II. Sequence
RT features of the 4,251,695 bp regions covered by 90 P1, TAC and BAC
RT clones.";
RL DNA Res. 7:217-221(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Shinn P., Chen H., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=16412086; DOI=10.1111/j.1365-313x.2005.02626.x;
RA Hu W., Ma H.;
RT "Characterization of a novel putative zinc finger gene MIF1: involvement in
RT multiple hormonal regulation of Arabidopsis development.";
RL Plant J. 45:399-422(2006).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [8]
RP INTERACTION WITH ZHD1; ZHD3; ZHD5; ZHD8; ZHD10 AND ZHD13, GENE FAMILY, AND
RP NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
RN [9]
RP FUNCTION.
RC STRAIN=cv. Columbia;
RX PubMed=21455630; DOI=10.1007/s11103-011-9768-y;
RA Hu W., Feng B., Ma H.;
RT "Ectopic expression of the Arabidopsis MINI ZINC FINGER1 and MIF3 genes
RT induces shoot meristems on leaf margins.";
RL Plant Mol. Biol. 76:57-68(2011).
CC -!- FUNCTION: Inhibits zinc finger homeodomain (ZHD) transcription factors
CC by interacting with them to prevent both their nuclear localization and
CC their DNA-binding properties. Involved in integrating signals from
CC multiple hormones by regulating the expression of specific genes.
CC {ECO:0000269|PubMed:21455630}.
CC -!- SUBUNIT: Homo- and heterodimers (By similarity). Interacts with ZHD1,
CC ZHD3, ZHD5, ZHD8, ZHD10 and ZHD13. {ECO:0000250,
CC ECO:0000269|PubMed:21059647}.
CC -!- INTERACTION:
CC Q9LJW5; O24410: IAA20; NbExp=3; IntAct=EBI-15191779, EBI-632272;
CC Q9LJW5; Q5XEN5: MBD1; NbExp=4; IntAct=EBI-15191779, EBI-4445335;
CC Q9LJW5; Q9LXG0: ZHD8; NbExp=3; IntAct=EBI-15191779, EBI-1806405;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in stems, flowers and siliques,
CC and, to a lower extent, in inflorescence.
CC {ECO:0000269|PubMed:16412086}.
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DR EMBL; AP000386; BAB02135.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77506.1; -; Genomic_DNA.
DR EMBL; AK221094; BAD94968.1; -; mRNA.
DR EMBL; BT024663; ABD57488.1; -; mRNA.
DR EMBL; AY086885; AAM63930.1; -; mRNA.
DR RefSeq; NP_974373.1; NM_202644.2.
DR AlphaFoldDB; Q9LJW5; -.
DR BioGRID; 30503; 16.
DR IntAct; Q9LJW5; 16.
DR STRING; 3702.AT3G28917.1; -.
DR iPTMnet; Q9LJW5; -.
DR PaxDb; Q9LJW5; -.
DR PRIDE; Q9LJW5; -.
DR ProteomicsDB; 238319; -.
DR EnsemblPlants; AT3G28917.1; AT3G28917.1; AT3G28917.
DR GeneID; 2745896; -.
DR Gramene; AT3G28917.1; AT3G28917.1; AT3G28917.
DR KEGG; ath:AT3G28917; -.
DR Araport; AT3G28917; -.
DR TAIR; locus:1006230234; AT3G28917.
DR eggNOG; ENOG502S2AW; Eukaryota.
DR HOGENOM; CLU_123565_0_0_1; -.
DR InParanoid; Q9LJW5; -.
DR OMA; CTEFIPS; -.
DR OrthoDB; 1558346at2759; -.
DR PhylomeDB; Q9LJW5; -.
DR PRO; PR:Q9LJW5; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LJW5; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0010582; P:floral meristem determinacy; IMP:TAIR.
DR GO; GO:0035670; P:plant-type ovary development; IMP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Developmental protein; Metal-binding; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..100
FT /note="Mini zinc finger protein 2"
FT /id="PRO_0000426015"
FT ZN_FING 33..83
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 100 AA; 10793 MW; 25C296DE4CD929C3 CRC64;
MRKRQVVLRR ASPEEPSRSS STASSLTVRT VRYGECQKNH AAAVGGYAVD GCREFMASRG
EEGTVAALTC AACGCHRSFH RREIETEVVC DCNSPPSTGN
