ID   MIF3_ARATH              Reviewed;          88 AA.
AC   Q2Q493;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Mini zinc finger protein 3;
DE            Short=AtMIF3;
GN   Name=MIF3; OrderedLocusNames=At1g18835; ORFNames=F6A14;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=16412086; DOI=10.1111/j.1365-313x.2005.02626.x;
RA   Hu W., Ma H.;
RT   "Characterization of a novel putative zinc finger gene MIF1: involvement in
RT   multiple hormonal regulation of Arabidopsis development.";
RL   Plant J. 45:399-422(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   TISSUE SPECIFICITY, GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA   Hu W., dePamphilis C.W., Ma H.;
RT   "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT   zinc finger gene families.";
RL   J. Integr. Plant Biol. 50:1031-1045(2008).
RN   [5]
RP   INTERACTION WITH ZHD3; ZHD5; ZHD6; ZHD7; ZHD8; ZHD9; ZHD10 AND ZHD13, GENE
RP   FAMILY, AND NOMENCLATURE.
RC   STRAIN=cv. Columbia;
RX   PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA   Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT   "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT   modulated by a competitive peptide inhibitor in Arabidopsis.";
RL   J. Biol. Chem. 286:1659-1668(2011).
RN   [6]
RP   FUNCTION.
RC   STRAIN=cv. Columbia;
RX   PubMed=21455630; DOI=10.1007/s11103-011-9768-y;
RA   Hu W., Feng B., Ma H.;
RT   "Ectopic expression of the Arabidopsis MINI ZINC FINGER1 and MIF3 genes
RT   induces shoot meristems on leaf margins.";
RL   Plant Mol. Biol. 76:57-68(2011).
CC   -!- FUNCTION: Inhibits zinc finger homeodomain (ZHD) transcription factors
CC       by interacting with them to prevent both their nuclear localization and
CC       their DNA-binding properties. Involved in integrating signals from
CC       multiple hormones by regulating the expression of specific genes.
CC       Promotes the formation of ectopic shoot meristems on leaf margins.
CC       {ECO:0000269|PubMed:21455630}.
CC   -!- SUBUNIT: Homo- and heterodimers (By similarity). Interacts with ZHD3,
CC       ZHD5, ZHD6, ZHD7, ZHD8, ZHD9, ZHD10 and ZHD13. {ECO:0000250,
CC       ECO:0000269|PubMed:21059647}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mostly expressed in roots, stems and flowers,
CC       present in seedlings and leaves, and weakly observed in inflorescence
CC       and siliques. {ECO:0000269|PubMed:16412086,
CC       ECO:0000269|PubMed:18713354}.
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DR   EMBL; DQ217608; ABB20816.1; -; mRNA.
DR   EMBL; AC011809; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002684; AEE29768.1; -; Genomic_DNA.
DR   RefSeq; NP_001077560.1; NM_001084091.2.
DR   AlphaFoldDB; Q2Q493; -.
DR   STRING; 3702.AT1G18835.1; -.
DR   PaxDb; Q2Q493; -.
DR   PRIDE; Q2Q493; -.
DR   ProteomicsDB; 238338; -.
DR   EnsemblPlants; AT1G18835.1; AT1G18835.1; AT1G18835.
DR   GeneID; 5007704; -.
DR   Gramene; AT1G18835.1; AT1G18835.1; AT1G18835.
DR   KEGG; ath:AT1G18835; -.
DR   Araport; AT1G18835; -.
DR   TAIR; locus:4010713452; AT1G18835.
DR   eggNOG; ENOG502S421; Eukaryota.
DR   HOGENOM; CLU_123565_0_0_1; -.
DR   InParanoid; Q2Q493; -.
DR   OMA; CEYSPPP; -.
DR   OrthoDB; 1558346at2759; -.
DR   PhylomeDB; Q2Q493; -.
DR   PRO; PR:Q2Q493; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q2Q493; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0048509; P:regulation of meristem development; IMP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR   Pfam; PF04770; ZF-HD_dimer; 1.
DR   TIGRFAMs; TIGR01566; ZF_HD_prot_N; 1.
DR   PROSITE; PS51523; ZF_HD_DIMER; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Metal-binding; Reference proteome;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..88
FT                   /note="Mini zinc finger protein 3"
FT                   /id="PRO_0000426016"
FT   ZN_FING         26..72
FT                   /note="ZF-HD dimerization-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
SQ   SEQUENCE   88 AA;  9751 MW;  D63055932C5131A6 CRC64;
     MKKRQVVIKQ RKSSYTMTSS SSNVRYVECQ KNHAANIGGY AVDGCREFMA SGGDDALTCA
     ACGCHRNFHR REVDTEVVCE YSPPNANN