ID   MIFH_TRIMR              Reviewed;          19 AA.
AC   P81530;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 1.
DT   25-MAY-2022, entry version 43.
DE   RecName: Full=L-dopachrome-methyl ester tautomerase;
DE            EC=5.3.3.12;
DE   AltName: Full=Macrophage migration inhibitory factor homolog;
DE   Flags: Fragment;
OS   Trichuris muris (Mouse whipworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Enoplea; Dorylaimia;
OC   Trichinellida; Trichuridae; Trichuris.
OX   NCBI_TaxID=70415;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9794786; DOI=10.1042/bj3350495;
RA   Pennock J.L., Behnke J.M., Bickle Q.D., Devaney E., Grencis R.K.,
RA   Isaac R.E., Joshua G.W.P., Selkirk M.E., Zhang Y., Meyer D.J.;
RT   "Rapid purification and characterization of L-dopachrome-methyl-ester
RT   tautomerase (macrophage migration inhibitory factor) from Trichinella
RT   spiralis, Trichuris muris and Brugia pahangi.";
RL   Biochem. J. 335:495-498(1998).
CC   -!- FUNCTION: Tautomerization of the methyl ester of L-dopachrome.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-dopachrome = 5,6-dihydroxyindole-2-carboxylate;
CC         Xref=Rhea:RHEA:13041, ChEBI:CHEBI:16875, ChEBI:CHEBI:57509;
CC         EC=5.3.3.12;
CC   -!- INDUCTION: Inhibited by free fatty acids and haematin.
CC   -!- SIMILARITY: Belongs to the MIF family. {ECO:0000305}.
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DR   AlphaFoldDB; P81530; -.
DR   Proteomes; UP000046395; Unassembled WGS sequence.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0004167; F:dopachrome isomerase activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Cytokine; Direct protein sequencing; Isomerase.
FT   CHAIN           1..>19
FT                   /note="L-dopachrome-methyl ester tautomerase"
FT                   /id="PRO_0000158075"
FT   NON_TER         19
SQ   SEQUENCE   19 AA;  2058 MW;  F7D70C81D12F1234 CRC64;
     PIFTFASNVP ADTITGFFL