MIG18_CAEEL
ID MIG18_CAEEL Reviewed; 228 AA.
AC O45348;
DT 30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 2.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Abnormal cell migration protein 18 {ECO:0000312|WormBase:F11F1.6};
DE Flags: Precursor;
GN Name=mig-18 {ECO:0000312|WormBase:F11F1.6};
GN ORFNames=F11F1.6 {ECO:0000312|WormBase:F11F1.6};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND MUTAGENESIS OF 214-TRP--ASN-228.
RX PubMed=10388818; DOI=10.1093/genetics/152.3.985;
RA Nishiwaki K.;
RT "Mutations affecting symmetrical migration of distal tip cells in
RT Caenorhabditis elegans.";
RL Genetics 152:985-997(1999).
RN [3] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND MUTAGENESIS OF
RP CYS-21 AND 209-TRP--ASN-228.
RX PubMed=24318535; DOI=10.1534/genetics.113.157685;
RA Kim H.S., Kitano Y., Mori M., Takano T., Harbaugh T.E., Mizutani K.,
RA Yanagimoto H., Miwa S., Ihara S., Kubota Y., Shibata Y., Ikenishi K.,
RA Garriga G., Nishiwaki K.;
RT "The novel secreted factor MIG-18 acts with MIG-17/ADAMTS to control cell
RT migration in Caenorhabditis elegans.";
RL Genetics 196:471-479(2014).
CC -!- FUNCTION: Required for the directional control of distal tip cell
CC migration during gonadogenesis, probably by recruiting fibulin fbl-1 to
CC the gonad basement membrane. {ECO:0000269|PubMed:10388818,
CC ECO:0000269|PubMed:24318535}.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000269|PubMed:24318535}.
CC Note=Colocalizes with metalloprotease mig-17 to the gonad basement
CC membrane. {ECO:0000269|PubMed:24318535}.
CC -!- TISSUE SPECIFICITY: Expressed in body wall muscle.
CC {ECO:0000269|PubMed:24318535}.
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DR EMBL; BX284603; CAB02928.2; -; Genomic_DNA.
DR PIR; T20793; T20793.
DR RefSeq; NP_499766.2; NM_067365.2.
DR AlphaFoldDB; O45348; -.
DR SMR; O45348; -.
DR STRING; 6239.F11F1.6; -.
DR EPD; O45348; -.
DR PaxDb; O45348; -.
DR PeptideAtlas; O45348; -.
DR EnsemblMetazoa; F11F1.6.1; F11F1.6.1; WBGene00003249.
DR GeneID; 184362; -.
DR KEGG; cel:CELE_F11F1.6; -.
DR UCSC; F11F1.6; c. elegans.
DR CTD; 184362; -.
DR WormBase; F11F1.6; CE33613; WBGene00003249; mig-18.
DR eggNOG; ENOG502S5V8; Eukaryota.
DR HOGENOM; CLU_1215758_0_0_1; -.
DR InParanoid; O45348; -.
DR OMA; SLHIKKY; -.
DR OrthoDB; 1203392at2759; -.
DR PRO; PR:O45348; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00003249; Expressed in larva and 3 other tissues.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR InterPro; IPR040282; Mig-18-like.
DR PANTHER; PTHR35572; PTHR35572; 1.
PE 1: Evidence at protein level;
KW Basement membrane; Developmental protein; Extracellular matrix;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..228
FT /note="Abnormal cell migration protein 18"
FT /evidence="ECO:0000255"
FT /id="PRO_5004159167"
FT CARBOHYD 135
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT MUTAGEN 21
FT /note="C->R: In tk35; abnormal distal tip cell migration
FT after the first turn during gonad morphogenesis."
FT /evidence="ECO:0000269|PubMed:24318535"
FT MUTAGEN 209..228
FT /note="Missing: In gm321; abnormal distal tip cell
FT migration after the first turn during gonad morphogenesis."
FT /evidence="ECO:0000269|PubMed:24318535"
FT MUTAGEN 214..228
FT /note="Missing: In k140; abnormal posterior, and to a
FT lesser extent anterior, distal tip cell (DTC) migration
FT after the first turn during gonad morphogenesis. Reduced
FT localization of fibulin fbl-1 to the gonad basement
FT membrane. Anterior DTC migration is more severely affected
FT in a mig-17 (k174) or nid-1 (cg119) mutant background.
FT Normal DTC migration is restored in a fib-1 (k201 or k206)
FT or let-2 (k196) mutant background."
FT /evidence="ECO:0000269|PubMed:10388818,
FT ECO:0000269|PubMed:24318535"
SQ SEQUENCE 228 AA; 25937 MW; 224F982C826FFFF4 CRC64;
MTFTLRLLVL CTVYSYVISQ CDDNGVIYTN GDKWIRNNHF LVTCRDGNIQ TLKCVTDSGH
LLEVGSKSYV ENGYEYMCAR EVTDNLNTNT CPTFADFSDD IFKDRFAICC ISRRFKGCVD
ANGDIVKSGF FVIGNKSLKY CRIQANQLQA RIEPKGCFNG TEKDDVNDEE LHIKKYAVWR
EGDIEYRCGD DGVHIQRCFP PELKKKAIWA GTAWIQEDGQ VKTCGKIN
