ID   MIG1_KLUMA              Reviewed;         543 AA.
AC   P52288;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Regulatory protein MIG1;
GN   Name=MIG1;
OS   Kluyveromyces marxianus (Yeast) (Candida kefyr).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=4911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 12424 / NRRL Y-610;
RX   PubMed=9230894; DOI=10.1007/s004380050469;
RA   Cassart J.-P., Oestling J., Ronne H., Vandenhaute J.;
RT   "Comparative analysis in three fungi reveals structurally and functionally
RT   conserved regions in the Mig1 repressor.";
RL   Mol. Gen. Genet. 255:9-18(1997).
CC   -!- FUNCTION: Involved in glucose repression of glucose metabolism genes.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the creA/MIG C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; Z50018; CAA90321.1; -; Genomic_DNA.
DR   AlphaFoldDB; P52288; -.
DR   SMR; P52288; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism; DNA-binding; Metal-binding; Nucleus; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..543
FT                   /note="Regulatory protein MIG1"
FT                   /id="PRO_0000046880"
FT   ZN_FING         32..54
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         60..84
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          73..102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          167..187
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          212..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          482..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        300..318
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        495..525
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   543 AA;  59315 MW;  DFC01BD92144622F CRC64;
     MSSEVVPLQK KGRKKAGAGV VVDGEKDGSR PYMCPICHRG FHRLEHQTRH IRTHTGERPH
     ACDFPGCAKR FSRSDELTRH RRIHDSDKPK GKRGRKKKSE TIAREKELEL QRQRQQQQLQ
     QQQQQQLQQQ QHQVLPAEIK ISAPMASSMM EVTQAINQRY QDTHNLSLSY NSGSNSNASS
     GSNSNSSLNQ VFSITSQPAR DLAAKPMFQL GSDESEETSN TTTLHSVHSQ QQNNGSVELL
     LNAARFESEK STTLLNNNTP SFKFIDRPPL TSSLSSPALS LVSQSPVAGA GPGFGPANGN
     GNGAANNNGL LLPRPTSRPK LSALSTLKRM TPLSQVSEPQ QPAASLPHLQ QVSSNGFLDT
     NGHAASVARN KSWTNLGVMP SPSESGSSAL VSRFSSSASL NKLMDPSSRT SSAVSIATLM
     NEDKLQSQDD LSVVDEFGRS RKKSKTSTPI RRPSSNMGFG TGPASHAMEF CNELQSRLKS
     VDQYSDRSAG DEKDYYFQSR SSSSVCTPIN SPPSERLVSS TSNNKTIKLP SLRSLDILPR
     EQH