ID   MIGA1_DANRE             Reviewed;         595 AA.
AC   Q5XJS0;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Mitoguardin 1 {ECO:0000250|UniProtKB:Q8NAN2};
DE   AltName: Full=Protein FAM73A {ECO:0000305};
GN   Name=miga1 {ECO:0000250|UniProtKB:Q8NAN2};
GN   Synonyms=fam73a {ECO:0000250|UniProtKB:Q8NAN2};
GN   ORFNames=zgc:101625 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of mitochondrial fusion: acts by forming homo- and
CC       heterodimers at the mitochondrial outer membrane and facilitating the
CC       formation of pld6/MitoPLD dimers. May act by regulating phospholipid
CC       metabolism via pld6/MitoPLD. {ECO:0000250|UniProtKB:Q8NAN2}.
CC   -!- SUBUNIT: Homodimer and heterodimer; forms heterodimers with miga2.
CC       {ECO:0000250|UniProtKB:Q8NAN2}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q8NAN2}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitoguardin family. {ECO:0000305}.
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DR   EMBL; BC083228; AAH83228.1; -; mRNA.
DR   RefSeq; NP_001006090.1; NM_001006090.1.
DR   AlphaFoldDB; Q5XJS0; -.
DR   STRING; 7955.ENSDARP00000027051; -.
DR   PaxDb; Q5XJS0; -.
DR   GeneID; 450070; -.
DR   KEGG; dre:450070; -.
DR   CTD; 374986; -.
DR   ZFIN; ZDB-GENE-041010-193; miga1.
DR   eggNOG; KOG3831; Eukaryota.
DR   InParanoid; Q5XJS0; -.
DR   OrthoDB; 341855at2759; -.
DR   PhylomeDB; Q5XJS0; -.
DR   Reactome; R-DRE-1483166; Synthesis of PA.
DR   PRO; PR:Q5XJS0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0008053; P:mitochondrial fusion; ISS:UniProtKB.
DR   InterPro; IPR019392; Miga.
DR   PANTHER; PTHR21508; PTHR21508; 1.
DR   Pfam; PF10265; Miga; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..595
FT                   /note="Mitoguardin 1"
FT                   /id="PRO_0000285648"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   595 AA;  66925 MW;  6DA403DF91530343 CRC64;
     MNEDVLRSSH LPIKLAALHF LDLPLSVYYS LPQVSLSTGT KKLFAATAFG AVSLIIIARR
     FRRRKGRRKA NSPVEQETFE FLTTIHLSKE SDSQSVPQNS ENPYTCNVVS GALYNKLSGS
     LPSLVSVRSR HSSSSSTCAN GSNCWEEAGD AADVCNLLSL PVATPENLYL MGMELFEEAL
     RRWEQALTFR SRQAEDEGSC VSVKLGAGDA IAEESMEDII SADFIQKLES LLQRAYRLQE
     EFEGSLGVTD PTTHPTNVLL ADKHMDLSVR EELEDTCLRD SISIASTDSF VSAAELSEHR
     EMRSGHALGS LSPHPFYEDA LQMAEEGKIS CRVLRTEMLE CLGDADFLAK LHCVRQACQV
     ILCERATRAF LADTGKRILS AIIAKARKSP KRFEEVFEEM ISFLEHTDHW ENTENELSSR
     GVKHMNFYDV VLDFILMDSF EDLENPPLSI QTVVNNRWLS NSFKETAVAS SCWSVLKQKR
     QHMKVQDGFI AHFYAVCEHI SPVLAWGFLG PKCTLQDFCC FFKEQVLFFL KDIFDLDKVR
     YFSLETLAED ILHLLHRRSD LLMAYLATDV IHHLNGCSDT SVHLVHSALL EAQVQ