ID   MIGA2_DANRE             Reviewed;         596 AA.
AC   Q5BLE2;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Mitoguardin 2 {ECO:0000250|UniProtKB:Q7L4E1};
DE   AltName: Full=Protein FAM73B {ECO:0000305};
GN   Name=miga2 {ECO:0000250|UniProtKB:Q7L4E1};
GN   Synonyms=fam73b {ECO:0000250|UniProtKB:Q7L4E1};
GN   ORFNames=zgc:113131 {ECO:0000303|Ref.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of mitochondrial fusion: acts by forming homo- and
CC       heterodimers at the mitochondrial outer membrane and facilitating the
CC       formation of pld6/MitoPLD dimers. May act by regulating phospholipid
CC       metabolism via pld6/MitoPLD. {ECO:0000250|UniProtKB:Q7L4E1}.
CC   -!- SUBUNIT: Homodimer and heterodimer; forms heterodimers with miga1.
CC       {ECO:0000250|UniProtKB:Q7L4E1}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000250|UniProtKB:Q7L4E1}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the mitoguardin family. {ECO:0000305}.
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DR   EMBL; BC090475; AAH90475.1; -; mRNA.
DR   RefSeq; NP_001013575.1; NM_001013557.1.
DR   AlphaFoldDB; Q5BLE2; -.
DR   STRING; 7955.ENSDARP00000109341; -.
DR   PaxDb; Q5BLE2; -.
DR   GeneID; 541431; -.
DR   KEGG; dre:541431; -.
DR   CTD; 84895; -.
DR   ZFIN; ZDB-GENE-050320-135; miga2.
DR   eggNOG; KOG3831; Eukaryota.
DR   InParanoid; Q5BLE2; -.
DR   OrthoDB; 341855at2759; -.
DR   PhylomeDB; Q5BLE2; -.
DR   Reactome; R-DRE-1483166; Synthesis of PA.
DR   PRO; PR:Q5BLE2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0008053; P:mitochondrial fusion; ISS:UniProtKB.
DR   InterPro; IPR019392; Miga.
DR   PANTHER; PTHR21508; PTHR21508; 1.
DR   Pfam; PF10265; Miga; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..596
FT                   /note="Mitoguardin 2"
FT                   /id="PRO_0000313660"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          67..158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          576..596
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        109..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        579..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   596 AA;  66256 MW;  4651C1003B6055F6 CRC64;
     MSFRSAEGVS IMQALAMTVA EIPVFLYSTF GQSIFSQLKL SPSLKKVLFA TALGSVALAL
     TAHQLKRRGR KRKQTLGKEA QKPVGIPEQL LRSSRPASLK RGPVPARQMM SPSTRSNDTL
     SGVSSIAQSK HSSSSHSIAS MRVPSSPNQS VNAGAAWEAE PVAEEPAVGE DANAENLYLM
     GMELFEEALR KWELALNIRH RSHSRASASN SQGSELVERH SPEVRNHQFA ERLETLLHRA
     YHLQEDFGST IPPDSLLADL ESEGTLILPT LGSSHPIQDD DATTVTSDDS FFSAAELFET
     FSLEDSFHLL KPAALYEEAL SLVKDGDVAC RSLRTELLEC YSDQDFLAKL HCVRQAFQVL
     LLDETHRMFF METGKQMISG LLVKANKSPK AFLESYEDML QYTQREETWP VSKMELEGRG
     VVCMNFFDIV LDFILMDAFE DLESPPSSVV AVLRNRWLSD SFKETALATA CWSVLKAKRR
     LLMVPDGFIA HFYVISEHVS PVLAFGFLGP HQHLSEVCTI FKQQIVQYLK DMFDHDKVRF
     TSVPSLAEDI LRLSHRRADI LMGYLGIENL PETNGALPKS PCQAESGNLD ASGQQD