ID   MIH_CALSI               Reviewed;         113 AA.
AC   P55321; Q23738;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Molt-inhibiting hormone;
DE            Short=MIH;
DE   Flags: Precursor;
OS   Callinectes sapidus (Blue crab).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea;
OC   Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura;
OC   Eubrachyura; Portunoidea; Portunidae; Callinectes.
OX   NCBI_TaxID=6763;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Eyestalk;
RX   PubMed=7537497; DOI=10.1006/bbrc.1995.1614;
RA   Lee K.J., Elton T.S., Bej A.K., Watts S.A., Watson R.D.;
RT   "Molecular cloning of a cDNA encoding putative molt-inhibiting hormone from
RT   the blue crab, Callinectes sapidus.";
RL   Biochem. Biophys. Res. Commun. 209:1126-1131(1995).
CC   -!- FUNCTION: Inhibits Y-organs where molting hormone (ecdysteroid) is
CC       secreted. A molting cycle is initiated when MIH secretion diminishes or
CC       stops (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the arthropod CHH/MIH/GIH/VIH hormone family.
CC       {ECO:0000305}.
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DR   EMBL; U19764; AAA69029.1; -; mRNA.
DR   PIR; JC4143; JC4143.
DR   AlphaFoldDB; P55321; -.
DR   SMR; P55321; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005184; F:neuropeptide hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.2010.10; -; 1.
DR   InterPro; IPR018251; Crust_neurhormone_CS.
DR   InterPro; IPR031098; Crust_neurohorm.
DR   InterPro; IPR035957; Crust_neurohorm_sf.
DR   InterPro; IPR001166; Hyperglycemic.
DR   InterPro; IPR001262; Hyperglycemic2.
DR   Pfam; PF01147; Crust_neurohorm; 1.
DR   PRINTS; PR00549; HYPRGLYCEMC2.
DR   PRINTS; PR00550; HYPRGLYCEMIC.
DR   SUPFAM; SSF81778; SSF81778; 1.
DR   PROSITE; PS01250; CHH_MIH_GIH; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Hormone; Neuropeptide; Secreted; Signal.
FT   SIGNAL          1..35
FT                   /evidence="ECO:0000255"
FT   PEPTIDE         36..113
FT                   /note="Molt-inhibiting hormone"
FT                   /id="PRO_0000019076"
FT   DISULFID        42..79
FT                   /evidence="ECO:0000250"
FT   DISULFID        59..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        62..88
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   113 AA;  12850 MW;  86AF3AE512130A5C CRC64;
     MMSLAHSKFS CQRTRLLAVV LLAALWSSSL QQAAARVIND DCPNLIGNRD LYKKVEWICD
     DCANIYRSTG MASLCRKDCF FNEDFLWCVR ATERSEDLAQ LKQWVTILGA GRI